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1 Dating Rare Mutations from Small Samples with Dense ... - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125402/
Common methods for dating mutations fall into three broad categories: methods based on the frequency of the mutation, methods based on gene trees, and methods ...
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2 Dating genomic variants and shared ancestry in population ...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000586
We have developed a method for estimating the age of genetic variants; that is, the time of origin of an allele through mutation at a single ...
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3 Dating Mutations - Colombo - - Major Reference Works
https://onlinelibrary.wiley.com/doi/abs/10.1002/9780470015902.a0005462.pub2
Abstract The age of a mutation can be estimated from the decay of linkage disequilibrium with flanking or intragenic polymorphisms because ...
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4 bahlolab/DatingRareMutations: Dating Rare Mutations from ...
https://github.com/bahlolab/DatingRareMutations
Dating Rare Mutations from Small Samples with Dense Marker Data. Online analysis. This application estimates the age of a genetic mutation, given the known ...
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5 Direct estimation of mutations in great apes ... - Nature
https://www.nature.com/articles/s41559-018-0778-x
The mutation rate per year is essential for the calibration of the molecular clock to enable dating of evolutionary events in human ancestry ...
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6 Estimating the age of rare disease mutations
https://jmg.bmj.com/content/41/6/445
Method of dating. We will first describe the principle of the method for two affected individuals who carry the studied mutation at the disease locus D, ...
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7 HGMD® home page
https://www.hgmd.cf.ac.uk/
The Human Gene Mutation Database (HGMD®) represents an attempt to collate all known (published) gene lesions responsible for human inherited disease and is ...
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8 Tracking SARS-CoV-2 variants
https://www.who.int/activities/tracking-SARS-CoV-2-variants
... aspects of the global strategy to reduce the occurrence of mutations that have negative public health implications. ... samples, Date of designation ...
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9 Molecular clock - Wikipedia
https://en.wikipedia.org/wiki/Molecular_clock
The benchmarks for determining the mutation rate are often fossil or archaeological dates. The molecular clock was first tested in 1962 on the hemoglobin ...
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10 SARS-CoV-2 Viral Mutations: Impact on COVID-19 Tests | FDA
https://www.fda.gov/medical-devices/coronavirus-covid-19-and-medical-devices/sars-cov-2-viral-mutations-impact-covid-19-tests
Omicron Variant and Sub-Variants: Impact on Molecular Tests. The FDA's analysis to date has identified certain EUA-authorized molecular tests ...
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11 Hypertrophic cardiomyopathy: Gene mutations and clinical ...
https://www.uptodate.com/contents/hypertrophic-cardiomyopathy-gene-mutations-and-clinical-genetic-testing
Factors that affect choice of treatment in NSCLC that lacks a driver mutation include the level of PD-L1 expression, the extent of disease, and ...
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12 Analysis of 6.4 million SARS-CoV-2 genomes identifies ...
https://www.science.org/doi/10.1126/science.abm1208
Mutations found in Variants of Concern (VoC), such as S:N439R, S:N501Y, and S:E484K, ... Relative fitness versus date of lineage emergence.
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13 SARS-CoV-2 Variant Classifications and Definitions - CDC
https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-classifications.html
A variant has one or more mutations that differentiate it from other ... To date, no variants of high consequence have been identified in the United States.
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14 Application of Statistical Learning to Identify Omicron ...
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2795987
Haplotypes of 28 Omicron mutations were used to define Omicron ... with each viral sequence included sample collection date and location.
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15 The Genetics of Cancer - Cancer.Net
https://www.cancer.net/navigating-cancer-care/cancer-basics/genetics/genetics-cancer
Ultraviolet (UV) radiation. Viruses. Age. Germline mutations. These are less common. A germline mutation occurs in a sperm ...
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16 COVID-19 CG: Tracking SARS-CoV-2 mutations by locations ...
https://www.biorxiv.org/content/10.1101/2020.09.23.310565v2
COVID-19 CG is an open resource for tracking SARS-CoV-2 single-nucleotide variations (SNVs) and lineages while filtering by location, date, ...
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17 Understanding the Omicron variant's mutations
https://www.washingtonpost.com/health/2021/12/16/omicron-variant-mutations-covid/
Number of mutations identified in each variant's. spike, date of earliest documented sample. BETA. ALPHA. DELTA. GAMMA. May 2020. Sept. 2020.
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18 HIV Drug Resistance Mutations - IAS-USA
https://www.iasusa.org/resources/hiv-drug-resistance-mutations/
... and the goal of the Drug Resistance Mutations Group is to maintain the most up-to-date compilation of mutations for HIV clinicians and researchers, ...
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19 (PDF) Dating Rare Mutations from Small Samples with Dense ...
https://www.researchgate.net/publication/262735142_Dating_Rare_Mutations_from_Small_Samples_with_Dense_Marker_Data
PDF | We present a method for estimating the age of a mutation based on ... Dating Rare Mutations from Small Samples with Dense Marker Data.
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20 Haplotype analysis of the internationally distributed BRCA1 c ...
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-01341-3
DMLE+ was used to date the mutation in Colombia and Iberia. ... Understanding founder mutations in diverse populations has implications in ...
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21 Cystic Fibrosis Mutation Database
http://www.genet.sickkids.on.ca/
The specific aim of the database is to provide up to date information about individual mutations in the CFTR gene. In a major upgrade in 2010, ...
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22 Mutation Age Estimation - WEHI Bioinformatics
https://bioinf.wehi.edu.au/software/ageofmutation/index.html
(2014). Dating rare mutations from small samples with dense marker data. Genetics, 197(4): 1315-27. Documentation can be found here.
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23 Direct estimation of mutations in great apes ... - Europe PMC
https://europepmc.org/article/med/30664699
Direct estimation of mutations in great apes reconciles phylogenetic dating. ... Here we inferred de novo mutations in chimpanzee, gorilla, and orangutan ...
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24 Nextstrain
https://nextstrain.org/
Since different genomes typically pick up different mutations, mutations can be used as ... we aim to allow exploration of continually up-to-date datasets, ...
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25 Researchers show how mutations in 'dark genome' cause ...
https://www.sciencedaily.com/releases/2022/08/220822130242.htm
Mutations in EnhP is most clear-cut example to date of how disruptions in non-protein coding DNA elements cause disease. Date: August 22, 2022 ...
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26 Most Comprehensive Whole-Genome Cancer Study To Date ...
https://news.weill.cornell.edu/news/2020/02/most-comprehensive-whole-genome-cancer-study-to-date-catalogs-tumor-driving-mutations
Unlike traditional cancer genetics projects that search for cancer-driving mutations only within protein-coding genes, the new project was a ...
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27 Omicron, Delta, Alpha, and More: What To Know About the ...
https://www.yalemedicine.org/news/covid-19-variants-of-concern-omicron
One explanation was that more than 30 of Omicron's mutations are on ... getting vaccinated and staying up to date with your vaccine and a ...
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28 Dating While Navigating a BRCA Mutation, Part 1
https://www.basser.org/resources/its-complicated-dating-while-navigating-brca-mutation-part-1
... at Foley Hoag LLC in New York City, the Basser Center for BRCA held a panel discussion on the ins and outs of dating with a BRCA mutation.
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29 Tracking Omicron and Other Coronavirus Variants
https://www.nytimes.com/interactive/2021/health/coronavirus-variant-tracker.html
Emerged in Colombia in early 2021. Lambda, C.37, Emerged in Peru in late 2020. Mutations that may help the coronavirus spread. Mutation ...
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30 Study of AG-120 in Previously Treated Advanced ...
https://clinicaltrials.gov/ct2/show/NCT02989857
IDH1 mutation testing will be performed at participating investigative sites. ... With Nonresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation.
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31 Largest Genetic Study to Date Unveils DNA Profiles That Lead ...
https://singularityhub.com/2022/04/26/largest-genetic-study-to-date-unveils-dna-profiles-that-lead-to-cancer/
Eventually, with no regard for their neighbors, mutated cells destroy tissues, organs, and life. But their set of genetic mutations—a signature— ...
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32 Mutations update data with TIMESTAMP | Cloud Spanner
https://cloud.google.com/spanner/docs/samples/spanner-update-data-with-timestamp-column
Update data in a table containing a TIMESTAMP column by using mutations. Explore further. For detailed documentation that includes this code sample, ...
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33 Leber Hereditary Optic Neuropathy - EyeWiki
https://eyewiki.aao.org/Leber_Hereditary_Optic_Neuropathy
LHON is classically associated with mitochondrial base pair mutations G11778A (guanine to adenine at position 11778), T14484C (tyrosine to ...
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34 Definition of time to progression - NCI Dictionary of Cancer ...
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/time-to-progression
The length of time from the date of diagnosis or the start of treatment for a disease until the disease starts to get worse or spread to other parts of the ...
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35 a review TSC1 and TSC2 gene mutations and ...
https://www.scielo.br/j/gmb/a/YGnxnhRTwWJHYVHVBbP8YBg/?lang=en
To date, specific mechanisms by which these loss of function mutations cause disease are not established. It is suggested that tumor formation is initiated ...
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36 Do all gene variants affect health and development?
https://medlineplus.gov/genetics/understanding/mutationsanddisorders/neutralmutations/
Only a small percent of gene variants (or mutations) cause genetic disorders ... the variant is evaluated using scientific research to date, ...
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37 A genetic method for dating ancient genomes ... - PNAS
https://www.pnas.org/doi/10.1073/pnas.1514696113
(6), who used the mutation clock (instead of the recombination clock as proposed here) to estimate the age of the Denisova finger bone, which is ...
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38 Gene Changes (Mutations) (for Parents) - Nemours KidsHealth
https://kidshealth.org/en/parents/gene-mutations.html
A gene mutation is a change in one or more genes. Some mutations can lead to genetic disorders or illnesses. ... Date reviewed: March 2021 ...
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39 Molecular clocks - Understanding Evolution
https://evolution.berkeley.edu/molecular-clocks/
Over the course of millions of years, mutations may build up in any given ... clocks to estimate divergence dates depends on other methods of dating.
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40 Cancer Cell Line Encyclopedia (CCLE) - Broad Institute
https://sites.broadinstitute.org/ccle/
For example, at the time of the discovery of EGFR mutations in lung cancer, ... and LOH data with mRNA expression date generated by the NCI60 cell line team ...
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41 Evolution of the mutation rate across primates - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S0959437X20300794
Germline mutations are the ultimate source of genetic diversity within and ... and hence a 'molecular clock' for dating past events [5,6].
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42 COVID-19 Variants: What You Need to Know About ...
https://www.houstonmethodist.org/blog/articles/2021/jan/covid-19-variants-what-you-need-to-know-about-coronavirus-mutations/
In some cases, however, these mutations can be advantageous to the virus. Each variant of COVID-19 is characterized by a ... Stay up-to-date.
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43 Tracking Variants - California Department of Public Health
https://www.cdph.ca.gov/Programs/CID/DCDC/Pages/COVID-19/COVID-Variants.aspx
Viruses change through mutations that create new strains of virus over time. ... with the CDC to gather up-to-date information about the Omicron variant.
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44 BRCA gene test for breast and ovarian cancer risk - Mayo Clinic
https://www.mayoclinic.org/tests-procedures/brca-gene-test/about/pac-20384815
Mutations in either breast cancer gene — BRCA1 or BRCA2 — significantly increase the ... Up-to-date information on recurrent breast cancer
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45 Clearance of Somatic Mutations at Remission and the Risk of ...
https://ascopubs.org/doi/10.1200/JCO.2017.77.6757
Event-free survival (EFS) was calculated from the date of CR to the date of relapse, or death for those without relapse, and censored on the ...
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46 Are leaky vaccines causing the new COVID-19 mutations?
https://www.nebraskamed.com/COVID/are-leaky-vaccines-causing-the-new-covid-19-mutations
Location first detected: India · Earliest sample date: Sept. 22, 2020 · India's vaccination efforts began Jan. 16, 2021.
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47 Study Challenges Evolutionary Theory That DNA Mutations ...
https://www.ucdavis.edu/food/news/study-challenges-evolutionary-theory-dna-mutations-are-random
Mutations occur when DNA is damaged and left unrepaired, creating a new variation. The scientists wanted to know if mutation was purely random ...
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48 Study Identifies Pitfall for Correcting Mutations in Human ...
https://www.cuimc.columbia.edu/news/study-identifies-pitfall-correcting-mutations-human-embryos-crispr
The most detailed analysis to date of CRISPR genome editing in human embryos finds a significant risk of chromosomal abnormalities when ...
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49 Direct estimation of mutations in great apes ... - ProQuest
https://search.proquest.com/openview/f021260f1874f577e9166e948f8e289c/1?pq-origsite=gscholar&cbl=4669716
The mutation rate per year is essential for the calibration of the molecular clock to enable dating of evolutionary events in human ancestry, such as human ...
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50 FDA Approves Trikafta for Children Ages 6 Through 11 With ...
https://www.cff.org/news/2021-06/fda-approves-trikafta-children-ages-6-through-11-certain-mutations
FDA Approves Trikafta for Children Ages 6 Through 11 With Certain Mutations · Stay up to date with The Foundation.
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51 Researchers show how mutations in 'dark genom | EurekAlert!
https://www.eurekalert.org/news-releases/962345
Mutations in EnhP is most clear-cut example to date of how disruptions in non-protein coding DNA elements cause disease.
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52 UFM1 founder mutation in the Roma population ... - Neurology
https://n.neurology.org/content/89/17/1821
This study, focused on identifying the mutated gene in patients with H-ABC without TUBB4A mutations, revealed a homozygous 3-bp deletion in the ...
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53 Probing Question: What is a molecular clock? - Penn State
https://www.psu.edu/news/research/story/probing-question-what-molecular-clock/
"If the rate is 5 mutations every million years, and you count 25 mutations in ... More rapidly changing genes are used to date more recent ...
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54 Mutation of the OsGlyRS3 gene affects heading date in rice
https://www.tandfonline.com/doi/full/10.1080/15592324.2021.1913366
› ... › Volume 16, Issue 7
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55 Harmful protein-coding mutations in people arose largely in ...
https://www.washington.edu/news/2012/11/28/harmful-protein-coding-mutations-in-people-arose-largely-in-the-past-5000-to-10000-years/
A study dating the age of more than 1 million single-letter variations in the human DNA code reveals that most of these mutations are of ...
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56 SARS-CoV-2 mutations, their attributes, and conducting ...
https://www.thermofisher.com/blog/ask-a-scientist/sars-cov-2-mutations-attributes-conducting-surveillance-studies/
› blog › ask-a-scientist
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57 Viruses and Evolution - History of Vaccines
https://historyofvaccines.org/vaccines-101/what-do-vaccines-do/viruses-and-evolution/
Take, for example, a virus with a mutation that makes it particularly deadly to its ... To date, researchers have developed several candidate HIV vaccines, ...
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58 Mitochondrial DNA Mutation Rates - UNC Computer Science
https://www.cs.unc.edu/~plaisted/ce/mitochondria.html
This scheme is attractive because it does not depend on radiometric dating or other assumptions about evolution or mutation rates.
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59 How the Omicron Variant Got So Many Scary Mutations So ...
https://www.scientificamerican.com/article/how-the-omicron-variant-got-so-many-scary-mutations-so-quickly/
On November 25, South African scientists announced the discovery of a new, “heavily mutated” variant of the coronavirus, triggering global ...
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60 Lamin A/C Gene Mutation Associated With Dilated ...
https://www.ahajournals.org/doi/full/10.1161/01.CIR.101.5.473
(2003) The Limb Girdle Muscular Dystrophies, Journal of Clinical Neuromuscular Disease, 10.1097/00131402-200309000-00003, 5:1, (12-28), Online publication date: ...
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61 GISAID - gisaid.org
https://gisaid.org/
Audacity Instant App · CoVsurver mutations App · FluSurver mutations App · Influenza genomic epidemiology · Audacity Instant App · CoVsurver mutations App ...
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62 Adjuvant Olaparib for Patients with BRCA1- or BRCA2 ...
https://www.nejm.org/doi/full/10.1056/NEJMoa2105215
New therapies are needed to reduce recurrence in patients with BRCA1 or BRCA2 germline mutation–associated early breast cancer.
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63 Covid strains: All the major virus mutations we know about
https://www.cnbc.com/2021/01/12/covid-mutations-all-the-major-strains-we-know-about.html
The new coronavirus has undergone several major mutations, ... are kept up to date by scientists around the world as major variants emerge.
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64 Genetics and CF | The Cystic Fibrosis Center at Stanford
https://med.stanford.edu/cfcenter/education/english/Genetics.html
To date, over 700 mutations of the CFTR gene have been identified. A person with CF inherits two mutated copies of the CFTR gene. These mutations can either be ...
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65 Mutations thought to be harmless turn out to cause problems
https://arstechnica.com/science/2022/06/mutations-thought-to-be-harmless-turn-out-to-cause-problems/
Mutations in genes that don't alter proteins can still alter survival in yeast.
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66 GraphQL schema basics - Apollo GraphQL Docs
https://www.apollographql.com/docs/apollo-server/schema/schema/
The schema also specifies exactly which queries and mutations are available for ... We want the app to show the name, date, and location of each event, ...
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67 Predicting height based on DNA mutations - Florian Privé
https://privefl.github.io/blog/predicting-height-based-on-dna-mutations/
So, with this model combining sex, birth date and DNA mutations, predictions are precise within 8 cm for 90% of people and within 4 cm for ...
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68 Land Record,Jharkhand
https://jharbhoomi.jharkhand.gov.in/Default
Date - 04/12/2022. 1070 / 279 / 697. NewCases/Rejected/Disposed. More info. 66 Days / 43 Days. Average / Median ... Total Mutation Cases: District-wise ...
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69 Overview of BRIP1 gene mutations
https://www.facingourrisk.org/info/hereditary-cancer-and-genetic-testing/hereditary-cancer-genes-and-risk/genes-by-name/brip1
Sign Up for FORCE Newsletters to stay up-to-date on hereditary cancer news, research, support, advocacy and clinical trial information.
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70 SMO 21 - Science Museum Oklahoma
https://www.sciencemuseumok.org/smo21
... Monsters, Mutations & Mayhem, Wizarding School, Summer Camp and more! Stay tuned for upcoming announcements about the next SMO21 theme and date.
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71 Carrier Screening for Genetic Conditions - ACOG
https://www.acog.org/clinical/clinical-guidance/committee-opinion/articles/2017/03/carrier-screening-for-genetic-conditions
Genetic counseling is recommended. CFTR Mutation Panels. To date, more than 1,700 mutations have been identified for cystic fibrosis 9. Current guidelines, ...
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72 COSMIC | Catalogue of Somatic Mutations in Cancer
https://cancer.sanger.ac.uk/cosmic
Projects · COSMIC The core of COSMIC, an expert-curated database of somatic mutations · Cell Lines Project Mutation profiles of over 1,000 cell lines used in ...
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73 Prothrombin G20210A (Factor II Mutation) Resources
https://www.stoptheclot.org/learn_more/prothrombin-g20210a-factor-ii-mutation/
A Genetic Clotting Condition or Thrombophilia. Prothrombin 20210 Mutation, also called Factor II Mutation is a genetic condition that causes an increase in the ...
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74 Advance Online Articles (date view) - Genome Research
https://genome.cshlp.org/content/early/recent
November 23, 2022 · Gene essentiality in cancer cell lines is modified by the sex chromosomes. Shahar Shohat, · Analyzing rare mutations in ...
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75 FDA approves Novartis Piqray® - the first and only treatment ...
https://www.novartis.com/news/media-releases/fda-approves-novartis-piqray-first-and-only-treatment-specifically-patients-pik3ca-mutation-hrher2-advanced-breast-cancer
Piqray targets the effect of PIK3CA mutations and may help overcome ... the information in this press release as of this date and does not ...
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76 Mutation Create Item : Date Format - monday Community Forum
https://community.monday.com/t/mutation-create-item-date-format/40711
I have this creation of item via c#. da is the date column id dueDate is “2022-08-16” string query = "{"query" : "mutation { create_item ...
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77 Mutation rates - ISOGG Wiki
https://isogg.org/wiki/Mutation_rates
In genetics, the mutation rate is a measure of the rate at which various ... DNA dating: How molecular clocks are refining human evolution's timeline by ...
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78 EGFR and Lung Cancer | American Lung Association
https://www.lung.org/lung-health-diseases/lung-disease-lookup/lung-cancer/symptoms-diagnosis/biomarker-testing/egfr
A mutation in the EGFR gene is one biomarker that physicians look for in non-small cell lung cancer.
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79 The New Science of Matchmaking: Dating Based on Your DNA
https://www.healthline.com/health-news/the-new-science-of-matchmaking-091614
As genetic testing draws scrutiny from the FDA, a new dating site says ... and send the kit back to be tested for mutations in a serotonin ...
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80 Dating app based on genetic matching not eugenics, scientist ...
https://www.theguardian.com/science/2019/dec/16/dating-app-genetic-matching-not-eugenics-scientist-says
George Church's dating app proposes to match users based on their DNA ... if they had similar genetic mutations that could result in rare, ...
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81 Mutations drive malignant melanoma - Harvard Gazette
https://news.harvard.edu/gazette/story/2013/01/mutations-drive-malignant-melanoma/
The highly “recurrent” mutations — occurring in the tumors of many people — may be the most common mutations in melanoma cells found to date ...
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82 Schemas and Types - GraphQL
https://graphql.org/learn/schema/
Every GraphQL service has a query type and may or may not have a mutation type. ... and your client should know to expect that format for any date fields.
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83 The population genetics of mutations: good, bad and indifferent
https://royalsocietypublishing.org/doi/10.1098/rstb.2009.0317
Population genetics is fundamental to our understanding of evolution, and mutations are essential raw materials for evolution.
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84 Independent methods for evolutionary genetic dating provide ...
https://link.springer.com/article/10.1007/s00439-005-0028-6
As to STR mutation rates the main findings are: (1) large variations among loci within the same dataset with both methods, also when the same ...
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85 UniProt
https://www.uniprot.org/

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86 ViralVar: A Web Tool for Multilevel Visualization of SARS-CoV ...
https://www.mdpi.com/1999-4915/14/12/2714/htm
... new mutations, and the visualization of changes in the mutational patterns of the virus over selected date ranges, within defined geographical regions, ...
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87 Somatic mutations in ageing and disease - YouTube
https://www.youtube.com/watch?v=AJiCG17oY8E
European Molecular Biology Laboratory (EMBL)
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88 Matchmaker: New crowdsourced sites for rare diseases - CNN
https://www.cnn.com/2016/02/29/health/rare-diseases-matchmaker
You can't prove a mutation in a gene is responsible for a disease with ... like an online dating site where “you have to create a profile in ...
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89 Eloquent: Mutators & Casting - Laravel - The PHP Framework ...
https://laravel.com/docs/9.x/eloquent-mutators
Array & JSON Casting; Date Casting; Enum Casting; Encrypted Casting ... defines how the attribute will be accessed and, optionally, mutated.
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90 Radioactive Clocks - Naturalism and The Theory of Evolution
http://www.detectingdesign.com/radiometricdating2.html
Well, for many former and even current Christians, radiometric dating of the ... mutation rate: 9.11.7 But what about the effect of beneficial mutations?
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91 Jamabandi
https://jamabandi.nic.in/
People can now view details of sanctioned mutations and jamabandi of any land in ... cultivation and up-to-date of various rights in land.
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92 Property Tax - Hyderabad - GHMC
https://www.ghmc.gov.in/Propertytax.aspx
Search your Property Tax · Know your Mutation Status · Mutation Abstract · Know your Property Tax Dues · Vacant Land Tax Dues · Calculate your property tax ...
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93 Revenue Department, Government of Himachal Pradesh
https://himachal.nic.in/index.php?lang=1&dpt_id=13
... this service will retrieve land records from Central Server and will display the last date/time when data would have been imported from tehsil server.
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