❤️ K Bxn Mouse Model Of Arthritis

Google Keyword Rankings for : k bxn mouse model of arthritis

1 The K/BxN arthritis model - PubMed
https://pubmed.ncbi.nlm.nih.gov/18491295/
Mice expressing both the T cell receptor (TCR) transgene KRN and the MHC class II molecule A(g7) (K/BxN mice) develop severe inflammatory arthritis, ...
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2 Using the K/BxN mouse model of endogenous, chronic ...
https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-019-0328-6
The K/BxN serum-transfer model is an established mouse model of RA that recapitulates the effector phase of the disease and has been examined ...
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3 The neuropathic phenotype of the K/BxN transgenic mouse ...
https://www.nature.com/articles/s41598-020-72441-5
The adult K/BxN transgenic mouse develops spontaneous autoimmune arthritis with joint remodeling and profound bone loss.
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4 The K/BxN Mouse Model of Inflammatory Arthritis | SpringerLink
https://link.springer.com/protocol/10.1007/978-1-59745-402-5_20
Mice expressing the KRN T cell receptor transgene and the MHC class II molecule Ag7 (K/B×N mice) develop severe inflammatory arthritis, and serum from these ...
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5 Arthritogenic Monoclonal Antibodies from K/BxN Mice
https://rupress.org/jem/article/195/8/1071/39566/Arthritogenic-Monoclonal-Antibodies-from-K-BxN
K/BxN TCR transgenic (tg) mice express a transgene-encoded TCR reactive to a self-peptide derived from the ubiquitously expressed glycolytic enzyme, glucose-6- ...
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6 The Role of Fc R Signaling in the K/B N Serum Transfer Model ...
https://www.jimmunol.org/content/jimmunol/169/11/6604.full.pdf
mice that carry the IAg7 MHC class II allele (K/. BxN) (1, 2). This model is similar to human rheumatoid arthritis (RA)3 in that both are chronic symmetric ...
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7 A novel mouse model that develops spontaneous arthritis and ...
https://ard.bmj.com/content/72/1/89
Conclusions K/BxAg7 mice recapitulate the same sequence of events occurring in patients with RA, namely an erosive, inflammatory arthritis followed by ...
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8 Characterization of the KRN Cell Transfer Model of ...
https://ajp.amjpathol.org/article/S0002-9440(10)60192-7/fulltext
One of these models, the K/BxN murine model, exists in two different forms. In the first form, KRN TCR transgenic mice are bred to nonobese diabetic mice and ...
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9 IL-17-producing T cells can augment autoantibody-induced ...
https://www.pnas.org/doi/10.1073/pnas.0912152106
In the K/BxN mouse model of inflammatory arthritis, T cells initiate disease by providing help to B cells to produce arthritogenic autoantibodies. Here, we have ...
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10 The K/BxN Mouse Model of Inflammatory Arthritis
https://www.researchgate.net/publication/226872783_The_KBxN_Mouse_Model_of_Inflammatory_Arthritis
A commonly used animal model of RA is the K/BxN mouse which express the KRN T cell receptor transgene and the MHC-II molecule IAg7 (Ditzel, 2004 ...
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11 Interleukin 17-expressing Innate Synovial Cells Drive K/Bxn ...
https://immunenetwork.org/DOIx.php?id=10.4110/in.2016.16.6.366
K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To ...
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12 The K/BxN mouse model of inflammatory arthritis: theory and ...
https://experts.arizona.edu/en/publications/the-kbxn-mouse-model-of-inflammatory-arthritis-theory-and-practic
Mice expressing the KRN T cell receptor transgene and the MHC class II molecule A(g7) (K/BxN mice) develop severe inflammatory arthritis, and serum from ...
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13 Analgesic effects of soluble epoxide hydrolase inhibitor in K ...
https://www.anesth-pain-med.org/journal/view.php?number=63
The K/BxN serum transfer arthritis mouse model uses antibodies directed to the early, late, and post-inflammatory phases. Unlike the systemic ...
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14 T Cell Expansion Is Essential for the Development of Arthritis ...
https://journals.aai.org/jimmunol/article-pdf/182/8/4649/1279641/zim00809004649.pdf
The K/BxN mouse is a model of rheumatoid arthritis that is thought to be mainly due to autoantibody-mediated inflammatory responses. We showed previously that ...
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15 Heme Oxygenase-1 Regulates the Progression of K/BxN ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052435
The inflammatory response was aggravated in HO-1+/− mice as shown by arthritic score and the migration of inflammatory cells that could be ...
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16 The K/BxN mouse: a model of human inflammatory arthritis ...
https://www.semanticscholar.org/paper/The-K%2FBxN-mouse%3A-a-model-of-human-inflammatory-Ditzel/2d46f6536b9d6b1f43753b3d4bd69b0c132f28b2
Semantic Scholar extracted view of "The K/BxN mouse: a model of human inflammatory arthritis." by H. Ditzel.
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17 Inflammatory Arthritis in K/BxN Mice Is Associated with ...
https://acrabstracts.org/abstract/inflammatory-arthritis-in-kbxn-mice-is-associated-with-abnormal-hdl-function/
Inflammatory arthritis in K/BxN mice is associated with suppression of HDL- C levels and the generation of more pro-inflammatory, dysfunctional HDL particles.
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18 The KRN mouse model of inflammatory arthritis - CORE
https://core.ac.uk/download/pdf/159148025.pdf
The pathogenesis of arthritis in the K/BxN mouse model. The role of T cells. In the KRN TCR transgenic mice spontaneous arthritis development was only seen.
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19 Mouse Models of Rheumatoid Arthritis for Studies on ...
https://www.karger.com/Article/FullText/508239
The serum from K/BxN mice contains anti-G6PI autoantibodies and, thus, can be transferred to a variety of mouse strains, including B- and T-cell ...
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20 Mouse Models of Rheumatoid Arthritis - SAGE Journals
https://journals.sagepub.com/doi/10.1177/0300985815588612
K/BxN mice have a transgenic T-cell receptor that recognizes a peptide of G6PI (glucose-6-phophoisomerase) as an autoantigen in the context of MHC-II (I-Ag7).
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21 K/BxN Serum Transfer Arthritis as a Model of Inflammatory ...
http://www.imbm.sk/wp-content/uploads/2018/02/methodology.pdf
Here, we describe protocols for the usage of the K/BxN serum transfer arthritis (K/BxN) model, a well-described mouse model of inflammatory arthritis with.
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22 Medline ® Abstract for Reference 15 of 'Pathogenesis of ...
https://www.uptodate.com/contents/pathogenesis-of-rheumatoid-arthritis/abstract/15
In the K/BxN mouse model of arthritis, autoantibodies against glucose-6-phosphate isomerase cause joint-specific inflammation and destruction.
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23 Reduced Locomotor Activity Correlates with Increased ...
https://www.scirp.org/journal/paperinformation.aspx?paperid=43158
The K/BxN serum transfer arthritis in mice shares many immunological and pathological features with human RA. Very few studies are available in mice that ...
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24 NF-κB–inducing kinase controls lymphocyte and osteoclast ...
https://www.jci.org/articles/view/23763
We investigated the role of NIK in murine models of inflammatory arthritis using Nik–/– mice. The serum transfer arthritis model is initiated by ...
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25 Applicability and implementation of the collagen‑induced ...
https://www.spandidos-publications.com/10.3892/etm.2021.10371
Among these models, the collagen‑induced arthritis (CIA) mouse model is the first choice and the most widely used because it may be generated ...
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26 Th17 in Animal Models of Rheumatoid Arthritis | HTML - MDPI
https://www.mdpi.com/2077-0383/6/7/73/htm
CD4 T cells that infiltrated the joints in K/BxN mice secreted IL-17, and the deficiency of IL-17 or IL-23 considerably suppressed the development of K/BxN ...
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27 Pharmacologic induction of heme oxygenase 1 reduces acute ...
https://www.cochin-poa.com/wp-content/uploads/2017/03/Article-17.pdf
In the K/BxN mouse serum transfer model, which mimics human inflammatory arthritis without lymphocyte influence, HO-1 was up-regulated by intraperitoneal ...
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28 Tolerogenic Nanoparticles Impacting B and T ... - bioRxiv
https://www.biorxiv.org/content/10.1101/2020.07.02.185140v3.full
In K/BxN mice that develop autoimmune rheumatoid arthritis (RA) dependent on production of antibodies to the self-protein, glucose-6-phosphate ...
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29 Antiangiogenic Nanotherapy With Methotrexate ... - Medscape
https://www.medscape.com/viewarticle/730179_2
Arthritis was induced using the K/BxN mouse model of inflammatory arthritis ... Mice were also weighed prior to, and every day after, K/BxN serum transfer.
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30 Exercise protects against cardiac and skeletal muscle ...
https://journals.physiology.org/doi/full/10.1152/japplphysiol.00576.2020
Strikingly, we found that K/BxN mice, like patients with RA, also exhibit both cardiac and skeletal muscle myopathies that were correlated with ...
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31 NIH Public Access - Carolina Digital Repository
https://cdr.lib.unc.edu/downloads/8049gd73b
induced arthritis (CIA) and the K/BxN serum transfer models are two well-established mouse models of inflammatory arthritis that share many features with RA ...
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32 Experimental Animal Models for Rheumatoid Arthritis
https://synapse.koreamed.org/articles/1063972
The K/BxN mouse model of inflammatory arthritis: theory and practice. Methods Mol Med. 2007. 136:269–282. 26. Keffer J, Probert L, Cazlaris H, ...
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33 Tolerogenic Nanoparticles Impacting B and T Lymphocyte ...
https://pubs.acs.org/doi/10.1021/acschembio.1c00212
This model has been useful for the investigation of the development of autoimmunity (K/BxN transgenic mice) and particularly of the mechanisms ...
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34 K/BxN Serum Transfer Arthritis as a Model of Inflammatory ...
https://experiments.springernature.com/articles/10.1007/978-1-61779-561-9_19
In this chapter, we describe the usage of this rheumatoid arthritis model to investigate pain-like behavior in mice, including the assessment of clinical ...
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35 Synoviocyte-targeted therapy synergizes with TNF inhibition in ...
https://www.science.org/doi/10.1126/sciadv.aba4353
Serum from arthritic K/BxN mice was pooled for use in the K/BxN STIA model (27). To elicit STIA, 6- to 8-week-old mice were injected intraperitoneally with 100 ...
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36 1 Pain pathogenesis in rheumatoid arthritis - arXiv
https://arxiv.org/pdf/1903.04987
TLR signaling increases nociceptive factors, such TNF and nerve growth factor [79,93], and joint inflammation in RA models [79,124]. In male K/BxN mice, spinal ...
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37 Histidine decarboxylase but not histamine receptor 1 or 2 ...
https://academic.oup.com/intimm/article/21/11/1263/693029
Mast cell-deficient mice were completely protected against K/BxN serum-induced arthritis (5) and mast cells in the synovium were found to ...
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38 Immune-Mediated Arthritis and the HPA Axis - Arbor Assays
https://www.arborassays.com/immune-mediated-arthritis-and-the-hpa-axis/
Unlike the glucocorticoids, differences in 11β-HSD1 gene expression were observed between the two models. The K/BxN mice showed no change in 11β ...
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39 Mechanism of Immunoregulatory Properties of Vasoactive ...
https://www.readcube.com/articles/10.3389/fimmu.2021.701862
The K/BxN mouse model of rheumatoid arthritis (RA) closely resembles the human disease. In this model, arthritis results from activation of ...
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40 Animal models of rheumatoid pain: experimental systems and ...
https://rdw.rowan.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1001&context=cmsru_facpub
Keywords: Arthritis, Inflammation, Pain, Animal models, Nociception. Background ... The K/BxN model K/BxN mice express a T-cell receptor.
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41 G-Protein Receptor Kinases (grKs) Play an Important ...
https://www.jacionline.org/article/S0091-6749(06)03403-8/fulltext
CONCLUSIONS: The grK system is an important regulatory pathway in the K/BxN serum transfer model of inflammatory arthritis, but differs between the grK ...
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42 An intra-articular salmon calcitonin-based nanocomplex ...
https://researchrepository.ucd.ie/bitstream/10197/4364/1/JCR_Ryan_14012013_embedded_revised.doc
When NP were injected by the intra-articular (I.A.) route to the mouse knee during on-going inflammatory arthritis of the K/BxN serum transfer murine model, ...
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43 Roles of mast cells in rheumatoid arthritis
https://www.kjim.org/m/makeCookie.php?url=/m/journal/view.php?number=170259
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthritis, ... role in arthritis development in K/BxN RA mice model [38].
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44 Rodent Models of Rheumatoid Arthritis - Ingenta Connect
http://www.ingentaconnect.com/content/aalas/cm/2005/00000055/00000002/art00001?crawler=true
Although the K/BxN and collagen-induced arthritis (CIA) models in mice are probably the most widely used, new models may be found.
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45 Myeloid Krüppel-Like Factor 2 Critically Regulates K/BxN ...
https://mdpi-res.com/d_attachment/cells/cells-08-00908/article_deploy/cells-08-00908.pdf?version=1565947963
The K/BxN serum-induced arthritis model is ideal for studying disease ... K/BxN serum was collected from 8-week-old arthritic K/BxN mice and ...
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46 4.3. The K/BxN Serum Transfer Arthritis Model and the Experimental ...
https://bio-protocol.org/bio101/r9036335
Mice were monitored afterwards for 5 days with clinical scoring of arthritis severity, fluorescence imaging of the vascular leakage, and luminescence imaging of ...
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47 Using the K/BxN mouse model of - Ebsco
https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=14712172&AN=140156045&h=0vJQdYu24U2nD5WvRr4sDsthHngLR7xZrxGFaGMO090FpaUaIkcveX90tP6QDuSH2lJN%2F%2FqdAvSsDj0H91Pwgw%3D%3D&crl=f
autoimmune mouse models. We have now examined its efficacy compared to IVIg and SCIg in the K/BxN mouse model of endogenous, chronic rheumatoid arthritis ...
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48 Rheumatoid Arthritis Models - Charles River Laboratories
https://www.criver.com/products-services/discovery-services/pharmacology-studies/inflammation-autoimmune-studies/rheumatoid-arthritis-models
Animal Models of Rheumatoid Arthritis ... Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that principally attacks the joints, producing an ...
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49 Inflammatory arthritis can be reined in by CpG-induced DCâ ...
https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=1586&context=open_access_pubs
Furthermore, several animal models of inflam- ... in the K/BxN mouse model of inflammatory ... Certain CpGs inhibit K/BxN serum-transferred arthritis.
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50 K/BxN Serum-Transfer Arthritis as a Model for Human ... - OUCI
https://ouci.dntb.gov.ua/en/works/4wGnvGJ4/
List of references · Kouskoff, Organ-specific disease provoked by systemic autoimmunity, Cell, № 87, с. · Matsumoto, Arthritis provoked by linked T and B cell ...
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51 Role of cellular and molecular factors involved in the K/BxN ...
https://kops.uni-konstanz.de/bitstream/handle/123456789/7987/NarendiranThesis.pdf?sequence=1
The recent K/BxN model is a spontaneous model of arthritis wherein arthritis occurs in mice that express both the transgene encoded KRN T cell receptor and ...
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52 Monoclonal anti‐CD8 therapy induces disease amelioration in ...
https://www.academia.edu/2718307/Monoclonal_anti_CD8_therapy_induces_disease_amelioration_in_the_K_BxN_mouse_model_of_spontaneous_chronic_polyarthritis
Using the K/BxN mouse model of spontaneous chronic arthritis, which shares many similarities with RA, we studied the potential of CD8+ T cell depletion with ...
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53 Inflammatory and Post-Inflammatory Nociception in a Model of ...
https://kclpure.kcl.ac.uk/portal/en/theses/inflammatory-and-postinflammatory-nociception-in-a-model-of-arthritis(04479d1b-e95f-427d-9f2d-e88bb7fd6bbf).html
Taken together, the findings of this thesis demonstrate that in the K/BxN serum transfer model of inflammatory arthritis, there are distinct ...
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54 Animal Models of Rheumatoid Arthritis - IntechOpen
https://www.intechopen.com/chapters/58567
For this model, K/BxN mice, which will jointly express the cell receptor T and the CMH II allele, are usually used. These mice typically develop no problem ...
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55 Mouse CIA - Chondrex
https://www.chondrex.com/documents/Mouse%20CIA.pdf
Collagen-induced arthritis (CIA) in mice shares immunological and pathological features with human rheumatoid arthritis (RA). The CIA model is ideal to ...
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56 Animal models for rheumatoid arthritis - HSTalks
https://hstalks.com/t/3076/animal-models-for-rheumatoid-arthritis/
Click to launch & play an online audio visual presentation by Prof. Rikard Holmdahl on Animal models for rheumatoid arthritis, ...
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57 Key to spreading inflammation in rheumatoid arthritis found
https://cosmosmagazine.com/science/inflammation-rheumatoid-arthritis/
Using a mice model of rheumatoid arthritis, immunologists investigated whether crosstalk between different types of neurons could be ...
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58 Glycosaminoglycans in Development, Health and Disease
https://books.google.com/books?id=lGpYf_WgEtIC&pg=PA425&lpg=PA425&dq=k+bxn+mouse+model+of+arthritis&source=bl&ots=7i49TY5vud&sig=ACfU3U1TH0tj5O8IfQwolAe3joWtfrscaw&hl=en&sa=X&ved=2ahUKEwi9n72hwOD7AhVJElkFHUGCBbYQ6AF6BQjmARAD
... RA initiation and development in the K/BxN mouse model of RA.4–6 Small joint ... K/BxN mice develop polyarthritis by 4–5 weeks of age with many of the ...
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