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1 Somatostatin Inhibits Insulin and Glucagon Secretion via Two ...
https://academic.oup.com/endo/article/141/1/111/2987997
Somatostatin (SST) potently inhibits insulin and glucagon release from pancreatic islets. Five distinct membrane receptors (SSTR1–5) for SST are known, and at ...
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2 Somatostatin: What It Is, Function & Symptoms - Cleveland Clinic
https://my.clevelandclinic.org/health/articles/22856-somatostatin
In other words, since insulin decreases blood glucose levels, your body releases somatostatin to stop insulin release when you have low blood ...
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3 Somatostatin | You and Your Hormones from the Society for ...
https://www.yourhormones.info/hormones/somatostatin/
Too much somatostatin results in extreme reduction in the secretion of many endocrine hormones. An example of this is suppression of insulin secretion from the ...
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4 Inhibitory effect of somatostatin on insulin secretion is not ...
https://joe.bioscientifica.com/view/journals/joe/225/1/19.xml
The inhibitory effect of somatostatin (SST) on insulin secretion in vivo is attributed to a direct effect on pancreatic beta cells, but this is inconsistent ...
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5 Insulin inhibits glucagon release by SGLT2-induced ... - Nature
https://www.nature.com/articles/s41467-018-08193-8
Somatostatin is a powerful inhibitor of glucagon secretion. We hypothesised that insulin's glucagonostatic action could be mediated by ...
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6 Paracrine regulation of somatostatin secretion ... - Springer Link
https://link.springer.com/article/10.1007/s00125-020-05288-0
A certain level of intra-islet communication is thought to exist, where the individual hormones may reach the other islet cells and regulate ...
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7 Somatostatin - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/somatostatin
It inhibits the secretion of growth hormone (GH; somatotropin), insulin, glucagons, and gut hormones and is generally inhibitory to gastrointestinal motility ...
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8 Somatostatin inhibits insulin secretion by a G-protein ...
https://www.jbc.org/article/S0021-9258(17)35249-3/pdf
Effects of Bay K 8644, K+, and SRIF on [Ca2+l;-We then asked the question does SRIF alter [Ca2+Ii to signal its effects on insulin release. When ...
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9 Somatostatin: Its Possible Role in Carbohydrate Homeostasis ...
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/586629
Somatostatin, a peptide inhibitor of growth hormone release originally isolated from the hypothalamus, is also present in D cells of pancreatic islets.
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10 Regulating Glucagon Secretion: Somatostatin in the Spotlight
https://diabetesjournals.org/diabetes/article/58/2/299/14873/Regulating-Glucagon-Secretion-Somatostatin-in-the
Glucagon is stored alongside insulin in the islet, albeit in a discrete cellular compartment, the pancreatic α-cell. Just as the metabolic ...
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11 The Endocrine Pancreas (Insulin, Glucagon, and Somatostatin)
https://www.youtube.com/watch?v=6ozTqeOWjGg
Medicosis Perfectionalis
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12 Does Somatostatin Inhibition of Insulin Secretion ... - JSTOR
https://www.jstor.org/stable/65079
hibition than is the second phase. In addition, somatostatin inhibition of insulin secretion during the second phase is "re- versed" by supplemental calcium ...
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13 Somatostatin - Wikipedia
https://en.wikipedia.org/wiki/Somatostatin
Somatostatin release is triggered by the beta cell peptide urocortin3 (Ucn3) to inhibit insulin release. · Inhibits the release of glucagon.
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14 Somatostatin Inhibition of Insulin and Gastrin Hypersecretion ...
https://www.nejm.org/doi/full/10.1056/NEJM197506262922606
SOMATOSTATIN has been reported to diminish basal insulin levels1 and to inhibit insulin secretion stimulated by glucose,2 arginine,3 ...
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15 Does somatostatin inhibition of insulin secretion involve two
https://www.pnas.org/doi/pdf/10.1073/pnas.73.1.248
Does somatostatin inhibition of insulin secretion involve two mechanisms of action? (calcium/differential sensitivities/dose-response/dual function).
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16 Glucose stimulates somatostatin secretion in pancreatic δ ...
https://rupress.org/jgp/article/151/9/e201912351/120463/Glucose-stimulates-somatostatin-secretion-in
However, the two types of islet cells do differ in several important respects. Whereas modulators of CICR do not affect glucose-induced insulin secretion from ...
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17 The somatostatin-secreting pancreatic δ-cell in health and ...
https://escholarship.org/content/qt2vd855ph/qt2vd855ph_noSplash_ad50855db8ccfb55532f86bce4811053.pdf
insulin therapy, and this effect may, via inhibition of glucagon secretion, increase the ... Furthermore, pancreatectomy does not lower plasma somatostatin.
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18 somatostatin | biochemistry - Britannica
https://www.britannica.com/science/somatostatin
somatostatin · islets of Langerhans, where it serves to block the secretion of both · insulin and · glucagon from adjacent cells. Insulin, glucagon ...
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19 Does somatostatin inhibition of insulin ... - Europe PMC
https://europepmc.org/article/pmc/pmc335878
Somatostatin, the hypothalamic growth hormone release inhibitory factor (GHRIF), directly inhibits both the first and second phases of insulin secretion.
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20 Somatostatin (IPR004250) - InterPro entry - EMBL-EBI
https://www.ebi.ac.uk/interpro/entry/IPR004250
Somatostatin (SST) also known as somatotropin release-inhibiting factor (SRIF), ... Somatostatin inhibits insulin and glucagon secretion via two receptors ...
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21 Somatostatin- and Epinephrine-Induced Modifications of 45 ...
https://www.jci.org/articles/view/108869
Somatostatin inhibits insulin release without any detectable effect upon the handling of calcium by the islets. In contrast, inhibition of insulin release by ...
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22 Somatostatin and diabetes - The American Journal of Medicine
https://www.amjmed.com/article/0002-9343(81)90584-2/fulltext
The location of somatostatin in pancreatic islet D cells suggests that it may act as a local regulator of insulin and glucagon secretion. Changes in islet D- ...
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23 Abnormal Regulation by Glucose of Somatostatin Secretion in...
https://journals.lww.com/pancreasjournal/abstract/1990/05000/abnormal_regulation_by_glucose_of_somatostatin.16.aspx
Summary We have investigated the influence of non-insulin-dependent diabetes on the ... somatostatin secretion in controls but failed to do so in STZ rats.
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24 Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas
https://www.science.org/doi/10.1126/science.184.4135.482
Somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats.
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25 Role of Somatostatin in the Regulation of Central and ... - MDPI
https://www.mdpi.com/1422-0067/21/7/2568
Somatostatin (SST), also known as somatotropin release-inhibiting factor, is a growth hormone inhibitory peptide that was first discovered in the hypothalamus ...
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26 Secretion of Insulin in Response to Diet and Hormones
https://www.pancreapedia.org/reviews/secretion-of-insulin-in-response-to-diet-and-hormones
Insulin binds to an insulin receptor on acinar tissue and potentiates amylase secretion (109). In contrast, somatostatin inhibits pancreatic exocrine ...
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27 Somatostatin Inhibits Insulin and Glucagon ... - ResearchGate
https://www.researchgate.net/publication/51360402_Somatostatin_Inhibits_Insulin_and_Glucagon_Secretion_via_Two_Receptor_Subtypes_An_in_Vitro_Study_of_Pancreatic_Islets_from_Somatostatin_Receptor_2_Knockout_Mice_1
Somatostatin, a hormone which is secreted by islet δ-cells inhibits insulin secretion, while glucagon, which is synthesized and secreted by ...
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28 Somatostatin inhibits insulin release via SSTR2 in the hamster ...
https://dr.lib.iastate.edu/bitstreams/fbd54e44-394e-4ff0-9b7d-383799b865b5/download
› bitstreams › download
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29 effect of somatostatin on glucose induced insulin release in ...
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793(74)80778-7
in man, somatostatin, besides inhibiting GH release, lowered basal plasma insulin levels [2]. Furthermore, somatostatin suppressed glucose-induced insulin ...
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30 A role for islet somatostatin in mediating sympathetic ...
https://www.tandfonline.com/doi/full/10.4161/isl.2.6.13858
Aims/hypothesis: Somatostatin (SST) released from islet δ-cells inhibits both insulin and glucagon secretion but the role of this tonic inhibition is ...
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31 INHIBITION OF INSULIN SECRETION BY SOMATOSTATIN
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(73)92873-0/fulltext
Injection of somatostatin, the hypothalamic growth-hormone-inhibiting factor, lowered basal plasma-insulin levels.
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32 Renal hemodynamic effects of somatostatin are not related to ...
https://www.kidney-international.org/article/S0085-2538(15)48415-7/fulltext
Somatostatin induces marked renal vasoconstriction and exogenous restoration of fasting insulin concentrations does not influence the renal vascular effects.
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33 Somatostatin receptors in congenital hyperinsulinism - Frontiers
https://www.frontiersin.org/articles/10.3389/fendo.2022.921357/full
Under healthy conditions, somatostatin secreted from pancreatic islet δ-cells reduces insulin release through somatostatin receptor induced cAMP ...
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34 Glucagon-like peptide-1 stimulates insulin secretion and then ...
https://www.endocrine-abstracts.org/ea/0037/ea0037ep158
Glucagon-like peptide-1 (GLP-1) is known to stimulate insulin and somatostatin secretion in pancreatic islet cells. The exogenous somatostatin inhibits ...
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35 Effect of Phentolamine on the Somatostatin-Induced Inhibition ...
https://www.metabolismjournal.com/article/0026-0495(78)90133-6/pdf
Inhibition of Glucagon and Insulin Secretion ... Somatostatin in- fused into the pancreatic artery at a dose of ... nergic receptor mechanisms do not play a.
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36 Paracrine regulation of somatostatin secretion ... - Diabetologia
https://diabetologia-journal.org/editors-choice/paracrine-regulation-of-somatostatin-secretion-by-insulin-and-glucagon-in-mouse-pancreatic-islets-published-online-12-10-2020/
The alpha and beta cells of the islets of Langerhans secrete glucagon and insulin, which play an important role in regulating plasma glucose ...
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37 Somatostatin inhibits glucagon AND insulin?? : r/Mcat - Reddit
https://www.reddit.com/r/Mcat/comments/s1wnhu/somatostatin_inhibits_glucagon_and_insulin/
Pancreatic somatostatin secretion is increased by high blood glucose levels, so it inhibits glucagon (which makes sense) but why insulin?
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38 Reduced somatostatin signalling leads to hypersecretion of ...
https://www.biorxiv.org/content/10.1101/2020.04.07.028258v1.full
1e), supporting the notion that the relationship between glucagon and glucose was altered in HFD mice. Insulin is a known paracrine inhibitor of ...
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39 Paracrine Regulation of Glucagon Secretion: The β-α-δ Model
https://www.math.fsu.edu/~dgalvis/journalclub/papers/09_21_2015.pdf
somatostatin, which is an inhibitor of both insulin and glucagon secretion. ... Does glucose suppress glucagon secretion directly through intrinsic ...
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40 Somatostatin inhibition of fructose-induced hypertension.
https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.14.2.117
tostatin would suppress the hyperinsulinemia that normally results when rats are fed a fructose- enriched diet,7-8-10'11 and if elevated plasma insulin.
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41 Inhibitory effect of somatostatin on ... - King's Research Portal
https://kclpure.kcl.ac.uk/portal/en/publications/inhibitory-effect-of-somatostatin-on-insulin-secretion-is-not-mediated-via-the-cns(8858128e-f3c1-4129-b680-5b468b6ccc94).html
The inhibitory effect of somatostatin (SST) on insulin secretion in vivo is attributed to a direct effect on pancreatic beta cells, but this is inconsistent ...
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42 Glucagon Responses of Isolated a Cells to Glucose, Insulin ...
https://www.endocrinepractice.org/article/S1530-891X(20)43091-5/fulltext
This inability of leptin to suppress glucagon in vitro could signify that it acts indirectly by causing the release of gluca- gon-suppressing peptides from the ...
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43 The role of somatostatin in GLP-1-induced inhibition of ...
https://d-nb.info/1135149852/34
induced insulin secretion (from increased beta cell glucose sensitivity) and inhibition of ... was that GLP-1 does not inhibit glucagon secretion during.
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44 Somatostatin - Vivo.Colostate.edu
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/otherendo/somatostatin.html
Cells within pancreatic islets secrete insulin, glucagon and somatostatin. Somatostatin appears to act primarily in a paracrine manner to inhibit the secretion ...
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45 Somatostatin | Biology Questions - Toppr
https://www.toppr.com/ask/en-us/question/somatostatin/
Somatostatin · Stimulates glucagon release and inhibits insulin release · Stimulates release of insulin and glucagon · Inhibits release of insulin and glucagon.
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46 Somatostatin receptor expression and biological functions
https://ujms.net/index.php/ujms/article/download/6405/12188
Type 1 diabetes is resulting from the selective destruction of insulin-producing beta- cells within the pancreatic islets. Somatostatin acts as an inhibitor ...
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47 Somatostatin - Structure - Function - TeachMePhysiology
https://teachmephysiology.com/gastrointestinal-system/other/somatostatin/
In the pancreas, SS is secreted by δ-cells (delta cells). Once released, it acts as a powerful inhibitor of glucagon and insulin secretion from the α- and β- ...
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48 Function and Expression of Somatostatin Receptors of the ...
https://hal.archives-ouvertes.fr/hal-00532000/document
Keywords: insulin, glucagon, endocrine islets, pancreas, somatostatin, ... directly suppress insulin synthesis and release (see below), ...
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49 Somatostatin | Osmosis
https://www.osmosis.org/learn/Somatostatin
The delta cells of the pancreas secrete somatostatin, which functions to inhibit insulin and glucagon release. Somatostatin is also called growth ...
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50 The effect of calcium on somatostatin inhibition of insulin ...
https://doi.org/10.1016/0304-4165(79)90024-2
The results indicate a dual action of somatostatin in the inhibition of insulin release, one involving the islet adenylate cyclase and one affecting the ...
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51 The Effect of Long Acting Somatostatin Analogue SMS 201 ...
https://www.kjim.org/m/makeCookie.php?url=/m/journal/view.php?number=15422
Somatostatin is a potent inhibitor of the growth hormone (GH) secretion. However, the short half-life as well as the rebound phenomenon have rendered it ...
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52 The Endocrine Pancreas | Anatomy and Physiology II
https://courses.lumenlearning.com/suny-ap2/chapter/the-endocrine-pancreas/
An inhibiting hormone, pancreatic somatostatin inhibits the release of both ... on their cell membranes and do not require insulin for glucose uptake.
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53 Somatostatin Health Benefits, Function & Side Effects
https://selfhacked.com/blog/somatostatin-function-benefits/
Somatostatin inhibits the release of hormones by binding to its five receptors (G-protein coupled receptors sst1 to sst5). sst2 and sst5 are ...
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54 Somatostatin and insulin mediate glucose-inhibited glucagon ...
https://www.semanticscholar.org/paper/Somatostatin-and-insulin-mediate-glucose-inhibited-Elliott-Ustione/d42c6d3980e116deb7fea78a321dd24416c5b4a5
It is concluded that somatostatin and insulin together are critical paracrine mediators of glucose-inhibited glucagon secretion and function ...
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55 Paracrine control of glucagon release by somatostatin (Review)
https://www.spandidos-publications.com/10.3892/ijmm.2013.1605
Thus, 2-deoxy-D-glucose provoked a concentration-related inhibition of both insulin and somatostatin release. At 8.5 mM 2-deoxy-D-glucose, ...
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56 ENDO2019 CHI Islets FINAL - Crinetics
https://crinetics.com/wp-content/uploads/2020/09/ENDO2019-CHI-Islets-FINAL.pdf
by different somatostatin receptor (sst) subtypes. Glucagon secretion from a-cells is inhibited through sst2 receptor activation and insulin secretion from ...
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57 Does somatostatin inhibit insulin? - MovieCultists.com
https://moviecultists.com/does-somatostatin-inhibit-insulin
Somatostatin (SST) potently inhibits insulin and glucagon release from pancreatic islets. Why does somatostatin inhibit insulin and glucagon? SST inhibits ...
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58 Insulin, Glucagon, and Somatostatin - Part One
https://partone.litfl.com/insulin,_glucagon,_and_somatostatin.html
Inhibits secretion pancreatic polypeptides including insulin and glucagon; May function as a neurotransmitter in the CNS. References. Barrett KE ...
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59 Somatostatin - GenScript
https://www.genscript.com/peptide/RP10226-Somatostatin.html
It inhibits the secretion of various other hormones, such as somatotropin, glucagon, insulin, thyrotropin, and gastrin. Somatostatin is a hormone comprising ...
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60 Insulin and glucagon: How they regulate blood sugar levels
https://www.medicalnewstoday.com/articles/316427
A person's blood sugar levels vary throughout the day, but insulin and glucagon keep them within a healthy range overall. When the body does not absorb or ...
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61 Stimulates glucagon release and inhibits insulin ... - Doubtnut
https://www.doubtnut.com/question-answer-biology/somatostatin-646061123
› somatostatin-646061123
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62 Cumulated Index Medicus
https://books.google.com/books?id=dayL_i7Rto4C&pg=PA15502&lpg=PA15502&dq=why+does+somatostatin+inhibit+insulin&source=bl&ots=vazxspSF0t&sig=ACfU3U1JLsSKJZ5VeRMLHYG2mjmMLhSB8A&hl=en&sa=X&ved=2ahUKEwj1ucnRyNv7AhV8i3IEHVorChEQ6AF6BQj9ARAD
Delta sleep inducing peptide inhibits somatostatin release via induction of local GVHR ... Somatostatin does not increase insulin - stimulated glucose al .
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63 Review of Surgery: Basic Science and Clinical Topics for ABSITE
https://books.google.com/books?id=N7BStxfFRv0C&pg=PA276&lpg=PA276&dq=why+does+somatostatin+inhibit+insulin&source=bl&ots=gmLq0p4fXn&sig=ACfU3U0ykG0Aw9ftmWe2LS19VQSm_Iq49w&hl=en&sa=X&ved=2ahUKEwj1ucnRyNv7AhV8i3IEHVorChEQ6AF6BQj-ARAD
Insulin and somatostatin inhibit glucagon secretion in a paracrine fashion within the islet. The same neural impulses that regulate insulin secretion also ...
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64 Hypothalamic Peptide Hormones and Pituitary Regulation
https://books.google.com/books?id=A6HzBwAAQBAJ&pg=PA148&lpg=PA148&dq=why+does+somatostatin+inhibit+insulin&source=bl&ots=Cii6CEbBz5&sig=ACfU3U1PYm6e8b0Cufd4hoWyuLnDVyipLw&hl=en&sa=X&ved=2ahUKEwj1ucnRyNv7AhV8i3IEHVorChEQ6AF6BQj_ARAD
(74) to inhibit the secretion of insulin and glucagon by the isolated perfused ... Current clinical interest in the use of somatostatin to inhibit glucagon ...
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65 Gastrointestinal Endocrinology - Page 249 - Google Books Result
https://books.google.com/books?id=h00GCAAAQBAJ&pg=PA249&lpg=PA249&dq=why+does+somatostatin+inhibit+insulin&source=bl&ots=GbMCmoLjI2&sig=ACfU3U0sTZL7rQUIkY1gX7uxVgDwZ6TSlQ&hl=en&sa=X&ved=2ahUKEwj1ucnRyNv7AhV8i3IEHVorChEQ6AF6BQiAAhAD
The following year, Hellman and Lernmark rediscovered somatostatin as an extract of pancreatic islet cells that potently inhibited the secretion of insulin ...
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