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1 Activation of NMDA receptors in lumbar spinothalamic cells is ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253366/
Upregulated expression of NMDA receptor in the paraventricular nucleus shortens ejaculation latency in rats with experimental autoimmune prostatitis.
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2 Upregulated expression of NMDA receptor in the ...
https://onlinelibrary.wiley.com/doi/pdf/10.1111/andr.12879
Background: Estimated 30%-40% of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) suffer from premature ejaculation (PE) ...
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3 Up‐regulated Expression of NMDA Receptor in the ...
https://www.researchgate.net/publication/343423266_Up-regulated_Expression_of_NMDA_Receptor_in_the_Paraventricular_Nucleus_Shortens_Ejaculation_Latency_in_Rats_with_Experimental_Autoimmune_Prostatitis
Background: Estimated 30%-40% of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) suffer from premature ejaculation ...
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4 Prostate-derived IL-1β upregulates expression of NMDA ...
https://www.ajandrology.com/article.asp?issn=1008-682X;year=2022;volume=24;issue=2;spage=213;epage=218;aulast=Yang
Keywords: chronic prostatitis; N-methyl-D-aspartic acid receptor; paraventricular nucleus; premature ejaculation; prostate-derived ...
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5 The drug treatment of delayed ejaculation - Abdel-Hamid
https://tau.amegroups.com/article/view/10477/11781
Moreover, significant effects of small effect size are observed indicating elevated T levels in premature ejaculation (PE), and decreased T levels in DE ...
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6 The Diagnostic Role of Neurophysiological Tests for ...
https://www.auajournals.org/doi/10.1097/JU.0000000000002198
Purpose:Premature ejaculation (PE) is one of the most common male sexual dysfunctions. Local anesthetics (LAs) and dapoxetine are frequently ...
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7 Activation of NMDA receptors in lumbar ... - Faculty Opinions
https://facultyopinions.com/article/9623957
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8 Pharmacology for the Treatment of Premature Ejaculation
https://www.imop.gr/sites/default/files/giuliano_pharmacol_rev_2012_pe_pharmacology.pdf
Pharmacology of current and future therapies for premature ejaculation . ... kinin-1 receptor; NMDA, N-methyl-D-aspartate; NO, nitric oxide;.
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9 Involvement of Histamine H3 Receptor Agonism in Premature ...
https://www.mdpi.com/1422-0067/23/4/2291/pdf-vor
receptor; H3R; premature ejaculation; electrophysiology; in vivo ... Powell, W.S.; Dominguez, J.M.; Hull, E.M. An NMDA antagonist impairs ...
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10 Glutamate in Male and Female Sexual Behavior - Frontiers
https://www.frontiersin.org/articles/589882
Early glutamate studies helped establish a relationship with male sexual ... This treatment increased their number of ejaculations and ...
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11 Upregulated expression of NMDA receptor in the paraventricular ...
https://www.semanticscholar.org/paper/Upregulated-expression-of-NMDA-receptor-in-the-in-Yang-Zhang/c351c1413cc1225e75ee6b48ee35923737d40da7
It is proposed that the glutamatergic system dysfunction in the paraventricular nucleus (PVN) may be involved in premature ejaculation, which is difficult ...
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12 Disorders of Ejaculation: An AUA/SMSNA Guideline (2020)
https://www.auanet.org/guidelines-and-quality/guidelines/disorders-of-ejaculation
Lifelong premature ejaculation is defined as poor ejaculatory control, associated bother, and ejaculation within about 2 minutes of initiation of ...
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13 improved treatments for premature ejaculation in humans
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2008131256
Provided are methods and compositions for the treatment of a sexual dysfunction such as premature ejaculation. In certain embodiments, a NMDA antagonist ...
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14 US Patent Application for Method to Treat Premature Ejaculation in ...
https://patents.justia.com/patent/20140296262
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15 N Methyl D Aspartic Acid Nmda Animal Rescue Serbia
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16 upregulates expression of NMDA receptor in the paraventricular ...
https://pesquisa.bvsalud.org/portal/resource/pt/wpr-928528
Prostate-derived IL-1β upregulates expression of NMDA receptor in the paraventricular nucleus and shortens ejaculation latency in rats with experimental ...
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17 MX2008007589A - A method to treat premature ejaculation in ...
https://patents.google.com/patent/MX2008007589A/en
206010036596 Premature ejaculation Diseases 0.000 title claims abstract description ... The NMDA receptor antagonist can be dextromethorphan, dextrorphan, ...
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18 NMDA-Mediated Activation of the Medial Amygdala Initiates a ...
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are critical to the early processing of VCS through NMDA ... missions, including ejaculations when they occurred. This number of.
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19 A Role for Preoptic Glutamate in the Regulation of Male ...
https://journals.sagepub.com/doi/abs/10.1177/1073858408322679
Glutamate activation of N-methyl-D-aspartate (NMDA) receptors in the MPOA is at least ... 5-Hydroxytryptamine in premature ejaculation: opportunities for ...
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20 Male Libido, Testosterone, & Neurotransmitters | Sanesco
https://sanescohealth.com/blog/male-libido-testosterone-nervous-system/
It may be that too much serotonin may inhibit sexual activity, but too little could mean premature ejaculation. So, the goal is to achieve ...
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21 Serotonin impairs copulation and attenuates ejaculation ...
https://psycnet.apa.org/record/2010-16138-012
Glutamate is released in the MPOA of male rats during copulation, ... Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: An ...
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22 Therapeutic targets for premature ejaculation - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0378512211002064
In the treatment of male sexual disorders, focus has been mainly on erectile dysfunction (ED) and ejaculatory disorders, primarily premature ejaculation (PE).
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23 United States Patent
https://patentimages.storage.googleapis.com/08/b8/d4/4e713c4dac673a/US8604082.pdf
sexual dysfunction Such as premature ejaculation. In certain. S371 (c)(1), embodiments, a NMDA antagonist (e.g., dextromethorphan).
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24 premature ejaculation — Blog — MyBioHack | Unlock Your ...
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25 Highlights From the American Pain Society Meeting - Medscape
https://www.medscape.com/viewarticle/455374_2
N-methyl-D-aspartate (NMDA) receptors in the spinal cord mediate the ... Double the Pleasure: Stim Patch Delays Early Ejaculation: Study.
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26 室旁核NMDA受体表达上调缩短实验性自身免疫性前列腺炎大鼠 ...
https://www.x-mol.com/paper/1290715632649248768
Estimated 30%‐40% of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) suffer from premature ejaculation (PE), ...
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27 Serotonin and the neurobiology of the ejaculatory threshold
https://dspace.library.uu.nl/bitstream/handle/1874/19749/jong_06_serotoninandtheneurobiology.pdf?sequence=1
Premature ejaculation is now often successfully treated with antidepressant drugs that alter serotonergic neurotransmis- sion (Waldinger, 2005), but drugs ...
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28 Premature Ejaculation | DrugBank Online
https://go.drugbank.com/indications/DBCOND0001304
Also known as: Premature ejaculation / Premature ejaculation disorder / Ejaculatio praecox / Ejaculation premature. Drugs; Drugs and Targets; Drug Trials ...
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29 “With tramadol, I ride like a Jaguar”: a qualitative study of ...
https://substanceabusepolicy.biomedcentral.com/articles/10.1186/s13011-020-00292-4
Thanks to tramadol for curing my premature ejaculation problems. ... Involvement of NMDA receptors in the antidepressant-like effect of ...
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30 NMDA and PACAP Receptor Signaling Interact to Mediate ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076365
First, rhythmic phosphorylation of the NR1 NMDA receptor subunit (pNR1, ... 8, and 12, or during the early subjective night (CT15) with ...
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31 Erectile Dysfunction In Diabetes Is Due To Selective Defect In ...
https://www.sciencedaily.com/releases/2007/03/070315150541.htm
Erectile dysfunction, retrograde ejaculation and the loss of seminal emission ... The involvement of an NO mechanism in the NMDA mediated ...
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32 IV Ketamine Infusion Therapy Las Vegas | American Male Clinic
https://americanmalewellness.com/iv-ketamine-therapy-las-vegas/
IV ketamine infusion therapy works by blocking NMDA receptors in the brain, ... Nad+ IV Therapy · Premature Ejaculation · Erectile Dysfunction · Hair Loss ...
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33 Naurex raises $18M to develop novel NMDA modulator in ...
https://generics.pharmaintelligence.informa.com/SC012913/Naurex%20raises%20$18M%20to%20develop%20novel%20NMDA%20modulator%20in%20depression
Ampio raises $16.9M as it advances PhIII premature ejaculation drug. Ampio Pharmaceuticals, a development-stage company, initially raised $15 million which ...
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34 Neurochemistry of Male Sexual Behavior | SpringerLink
https://link.springer.com/10.1007%2F978-0-387-30405-2_2
Ejaculation activated more neurons (i.e., immunoreactive for Fos––the protein product of the immediate-early gene c-fos) in the medial ...
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35 Sexual Incentive Motivation and Copulatory Behavior in Male ...
https://munin.uit.no/bitstream/handle/10037/24666/article.pdf?sequence=4&isAllowed=y
ejaculation. 32. 33. 34. Keywords: premature ejaculation, α2-adrenoceptor, tasipimidine, fadolmidine.
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36 Neurogenic Ejaculatory Disorders: Focus on Current and ...
http://www.eurekaselect.com/node/88691/4
Ejaculation is a complex and still poorly understood neurological mechanism ... Premature ejaculation (PE) is the most common sexual dysfunction among young ...
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37 The Role of NMDA Receptor Antagonists in Nicotine ...
https://www.eymj.org/DOIx.php?id=10.3349/ymj.2008.49.2.175
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38 Search results for NMDA (N-Methyl-D-aspartic acid) - MalaCards
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40 Normal male sexual function: emphasis on ... - eScholarship
https://escholarship.org/content/qt8pj0c0b9/qt8pj0c0b9.pdf
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41 Clomipramine - bionity.com
https://www.bionity.com/en/encyclopedia/Clomipramine.html
... Paroxetine) have also been used to treat premature ejaculation. ... As with other tricyclics, downregulation of NMDA receptors may also account for its ...
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42 Sciele Pharma and Plethora Solutions Announce Positive ...
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43 Keyword NMDA receptor antagonists - Psychiatria Polska
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44 Acute and Persistent Withdrawal Syndromes Following ...
https://www.karger.com/Article/Fulltext/506868
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45 Normal male sexual function: emphasis on ... - Europe PMC
https://europepmc.org/article/med/26385403
Bilateral lesions of the PVN with N-methyl-D-aspartate (NMDA) results in a one-third ... (116) demonstrated a prevalence of 72% of premature ejaculation in ...
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46 USMLE Content Outline
https://www.usmle.org/sites/default/files/2021-08/USMLE_Content_Outline.pdf
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47 Guibourtia tessmannii-induced fictive ejaculation in spinal ...
https://www.tandfonline.com/doi/full/10.1080/13880209.2017.1291692
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48 dorsal penile nerve (DPN) - Allie: Abbreviation / Long Form Info.
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http://www.symcat.com/symptoms/premature-ejaculation-plus-problems-with-orgasm
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52 Volume 33 Issue 11, October 2008 - Nature
https://www.nature.com/npp/volumes/33/issues/11
Genetic NMDA Receptor Deficiency Disrupts Acute and Chronic Effects of Cocaine but ... Rational use of Dapoxetine for the Treatment of Premature Ejaculation.
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55 The Role of Steroid Modulation of Amino Acid Transmitters in ...
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56 Physiology of Ejaculation: Emphasis on Serotonergic Control
https://europeanurology.com/article/S0302-2838(05)00310-6/fulltext/physiology-of-ejaculation-emphasis-on-serotonergic-control
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57 Saffron: Health Benefits, Side Effects, Uses, Dose & Precautions
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59 Serotonin reuptake inhibitor - Wikipedia
https://en.wikipedia.org/wiki/Serotonin_reuptake_inhibitor
A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of ... duloxetine, milnacipran), and premature ejaculation (e.g., dapoxetine) as ...
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60 ejaculatory latency time: Topics by Science.gov
https://www.science.gov/topicpages/e/ejaculatory+latency+time
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64 Psychopharmacology – EBPS
https://ebps.org/publications/psychopharmacology/
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66 Excitotoxic Lesions of the Nucleus Paragigantocellularis ...
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68 The Role of NMDA Receptor Antagonists in Nicotine ...
https://synapse.koreamed.org/articles/1030284
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69 NCT02417064 - Clinical Trials
https://clinicaltrials.gov/ProvidedDocs/64/NCT02417064/Prot_000.pdf
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70 Theory of Sexual Orgasm and Sexual Exhaustion Symptoms
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71 Pharmacodynamics - Accessdata.fda.gov
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73 Premature Ejaculation - Tower Urology
https://www.towerurology.com/mens-health/premature-ejaculation/
Most studies find that 20-30% of men suffer from premature ejaculation, making it the most common sexual dysfunction in men. Although it is ...
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74 Patent applications published 23 March 2011
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75 Method for treatment of premature ejaculation in humans
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82 Premature Ejaculation: Causes, Diagnosis and Treatments ...
https://www.mazemenshealth.com/premature-ejaculation/
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85 Prematureejaculation-currentconceptsinthe management
http://www.bioline.org.br/pdf?rm21002
Premature ejaculation (PE; early ejaculation or rapid ejaculation) is a common sexual problem affecting about 20-30% of men in the sexually active age group. PE ...
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86 Premature Ejaculation: From Etiology to Diagnosis and Treatment
https://books.google.com/books?id=iCXF3sWtgegC&pg=PA36&lpg=PA36&dq=nmda+premature+ejaculation&source=bl&ots=63oWyrnrvS&sig=ACfU3U0kcnli4YndGQ2Jo50Qaevlg3nAUQ&hl=en&sa=X&ved=2ahUKEwi44tG6lNn7AhVgVTABHYghA58Q6AF6BQi7AhAD
The pivotal role of MPOA in ejaculation has been documented in several experiments ... Bilateral chemical lesion of the PVN with NMDA was associated with 30 ...
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87 Premature ejaculation - Google Books Result
https://books.google.com/books?id=rBTtBQAAQBAJ&pg=PT22&lpg=PT22&dq=nmda+premature+ejaculation&source=bl&ots=sOiwOrtrPp&sig=ACfU3U1nrEh3xZ7b2o-Knwpm999Kjz7DDA&hl=en&sa=X&ved=2ahUKEwi44tG6lNn7AhVgVTABHYghA58Q6AF6BQi6AhAD
NMDA N-methyl-D-aspartate NNT number needed to treat NPH Neutral Protamine Hagedorn (insulin) NSAID non-steroidal anti-inflammatory drug NYHA New York Heart ...
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88 Electrical stimulation zaps premature ejaculation - ISRAEL21c
https://www.israel21c.org/electrical-stimulation-zaps-premature-ejaculation/
Some 15 million of them actively seek treatment. No, it's not Covid. We're talking about premature ejaculation. Today, there is no consistent or easy cure, only ...
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