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1 K/BxN Serum-Transfer Arthritis as a Model for Human ... - NCBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889615/
The K/BxN serum-transfer arthritis (STA) model is a murine model in which the immunological mechanisms occurring in rheumatoid arthritis ...
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2 Serum Transfer Model of Arthritis R Signaling in the K/B × N γ ...
https://www.jimmunol.org/content/jimmunol/169/11/6604.full.pdf
These autoantibodies transfer clinically apparent arthritis into most recipient mouse strains and systemic catabolism of the transferred Abs attenuates paw ...
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3 The K/BxN Arthritis Model - Monach - 2008 - Current Protocols
https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/0471142735.im1522s81
K/BxN transgenic mice have been useful for investigating the development of autoimmunity, and the serum transfer model has been particularly ...
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4 The K/BxN mouse: a model of human inflammatory arthritis
http://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(03)00249-1
Interestingly, whereas K/BxN mice developed chronic arthritis, arthritis induced by transfer of antibody or serum from arthritic K/BxN mice was transient, ...
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5 Heme Oxygenase-1 Regulates the Progression of K ... - PLOS
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052435
We have investigated the possible role of endogenous HO-1 in the effector phase of arthritis using the K/BxN serum transfer model of ...
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6 Interleukin 17-expressing Innate Synovial Cells Drive K/Bxn ...
https://immunenetwork.org/DOIx.php?id=10.4110/in.2016.16.6.366
K/BxN serum can induce arthritis in normal mice because of ... Therefore, a K/BxN serum transfer model allows for studies that focus ...
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7 Arthritogenic Monoclonal Antibodies from K/BxN Mice
https://rupress.org/jem/article/195/8/1071/39566/Arthritogenic-Monoclonal-Antibodies-from-K-BxN
As is typical of K/BxN arthritis, spontaneous or induced by serum transfer, there was a strong distal predominance. The pool induced the same disease ...
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8 The neuropathic phenotype of the K/BxN transgenic mouse ...
https://www.nature.com/articles/s41598-020-72441-5
Male and female arthritic K/BxN mice develop mechanical allodynia that ... persistent pain state present in K/BxN serum transfer arthritis.
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9 Analgesic effects of soluble epoxide hydrolase inhibitor in K ...
https://www.anesth-pain-med.org/journal/view.php?number=63
The K/BxN serum transfer mouse model of arthritis displays an initial inflammation and an associated tactile allodynia that continues on ...
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10 K/BxN Serum Transfer Arthritis as a Model of ... - Springer Link
https://link.springer.com/protocol/10.1007/978-1-61779-561-9_19
In this chapter, we describe the usage of this rheumatoid arthritis model to investigate pain-like behavior in mice, including the ...
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11 Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum ...
https://journals.aai.org/jimmunol/article/198/7/2916/109490/Deficiency-in-IL-1-Receptor-Type-2-Aggravates-K
To define the functional role of endogenous IL-1R2 in the K/BxN serum transfer arthritis model and in IL-1β– or LPS-induced systemic inflammation in vivo, IL- ...
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12 IL-17-producing T cells can augment autoantibody-induced ...
https://www.pnas.org/doi/10.1073/pnas.0912152106
T cells are dispensable at this stage, as arthritis can be induced effectively by transfer of K/BxN serum into T cell-deficient or alymphoid recipients.
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13 Arthritis Critically Dependent on Innate Immune System Players
https://www.sciencedirect.com/science/article/pii/S1074761302002753
Strikingly, transfer of serum (or purified anti-GPI Igs) from arthritic K/BxN mice into healthy animals provokes arthritis within days, even when the ...
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14 (PDF) K/BxN Serum-Transfer Arthritis as a Model for Human ...
https://www.researchgate.net/publication/303747095_KBxN_Serum-Transfer_Arthritis_as_a_Model_for_Human_Inflammatory_Arthritis
The K/BxN serum-transfer arthritis (STA) model is a murine model in which the immunological mechanisms occurring in rheumatoid arthritis ...
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15 K/BxN Serum-Transfer Arthritis as a Model for Human Inflammatory ...
https://www.semanticscholar.org/paper/K%2FBxN-Serum-Transfer-Arthritis-as-a-Model-for-Human-Christensen-Haase/e669f21d4dc8a2a3990ac2abc195ea88ec949944
The K/BxN serum-transfer arthritis (STA) model is a murine model in which the immunological mechanisms occurring in rheumatoid arthritis (RA) and other ...
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16 Characterization of the KRN Cell Transfer Model of ...
https://ajp.amjpathol.org/article/S0002-9440(10)60192-7/fulltext
In the second form, serum transferred from K/BxN mice into normal recipient mice induces arthritis due to the presence of arthritogenic antibodies specific ...
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17 EBioMedicine - The Lancet
https://www.thelancet.com/article/S2352-3964(18)30498-5/pdf
Methods: Arthritis was induced in wild type and myeloid Sirt6 knockout (mS6KO) mice using collagen-induced and K/BxN serum transfer models.
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18 K/BxN Serum Transfer Arthritis as a Model of Inflammatory ...
https://experiments.springernature.com/articles/10.1007/978-1-61779-561-9_19
Clinical and pathological signs following induction of K/BxN serum transfer arthritis. Characterization of mechanical hypersensitivity in mice subjected to ...
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19 Megakaryocytes compensate for Kit insufficiency in murine ...
https://www.jci.org/articles/view/84598/figure/1
Dose-dependent susceptibility of Wsh mice to K/BxN serum transfer arthritis. Options: View larger image (or click on image) Download as ...
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20 4.3. The K/BxN Serum Transfer Arthritis Model and the Experimental ...
https://bio-protocol.org/bio101/r9036335
The K/BxN Serum Transfer Arthritis Model and the Experimental Layout. BB Bálint Botz. GK Gábor Kriszta. KB Kata Bölcskei. ÁH Ádám István Horváth.
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21 Non-classical monocytes as mediators of tissue destruction in ...
https://ard.bmj.com/content/annrheumdis/early/2018/06/28/annrheumdis-2018-213250.full.pdf
subsets in htnFtg and K/Bxn serum transfer arthritis by flow cytometry. We sorted monocyte subsets and analysed their potential to ...
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22 Characterization of the acute and persistent pain state pres...
https://journals.lww.com/pain/fulltext/2010/11000/characterization_of_the_acute_and_persistent_pain.23.aspx
We characterized the K/BxN serum transfer arthritis model as a model of joint inflammation-induced pain and examined pharmacologic responsiveness and spinal ...
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23 G-Protein Receptor Kinases (grKs) Play an Important ...
https://www.jacionline.org/article/S0091-6749(06)03403-8/fulltext
CONCLUSIONS: The grK system is an important regulatory pathway in the K/BxN serum transfer model of inflammatory arthritis, but differs between the grK ...
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24 Antiangiogenic Nanotherapy With Methotrexate ... - Medscape
https://www.medscape.com/viewarticle/730179_2
Synergistic effect of fumagillin nanoparticles and methotrexate in inflammatory arthritis. Arthritis was induced by K/BxN serum transfer on day 0.
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25 Reduced Locomotor Activity Correlates with Increased ...
https://www.scirp.org/journal/paperinformation.aspx?paperid=43158
The K/BxN serum transfer arthritis in mice shares many immunological and pathological features with human RA. Very few studies are available in mice that ...
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26 A Unique Role for IL-18 Receptor-α in Monocyte Migration in ...
https://acrabstracts.org/abstract/a-unique-role-for-il-18-receptor-%CE%B1-in-monocyte-migration-in-ra-and-kbxn-serum-transfer-arthritis/
K/BxN serum transfer arthritis was performed in IL-18Rα null and wild type (wt) mice to determine the role of the IL-18Rα in arthritis and MN recruitment.
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27 Myeloid IPMK promotes the resolution of serum transfer ...
https://www.tandfonline.com/doi/full/10.1080/19768354.2021.1952305
Using myeloid cell-specific IPMK knockout (KO) mice, arthritis was induced via intraperitoneal K/BxN serum injection, after which disease ...
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28 Histidine decarboxylase but not histamine receptor 1 or 2 ...
https://academic.oup.com/intimm/article/21/11/1263/693029
Abstract. Serum transfer from arthritic K/BxN mice into naive animals results in arthritis. Mast cells have been shown to be essential since ...
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29 Lack of requirement of osteopontin for inflammation, bone ...
https://scholars.duke.edu/display/pub726899
... and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. ... OPN in the K/BxN serum-transfer model of autoantibody-induced arthritis.
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30 Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum ...
https://lasid.org/deficiency-in-il-1-receptor-type-2-aggravates-kbxn-serum-transfer-induced-arthritis-in-mice-but-has-no-impact-on-systemic-inflammatory-responses-innate-immunity-and-inflammation/
Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses [INNATE ...
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31 K/BxN Serum-Transfer Arthritis as a Model for Human ... - OUCI
https://ouci.dntb.gov.ua/en/works/4wGnvGJ4/
K/BxN Serum-Transfer Arthritis as a Model for Human Inflammatory Arthritis. https://doi.org/10.3389/fimmu.2016.00213. Journal: Frontiers in Immunology, 2016.
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32 Pharmacologic induction of heme oxygenase 1 reduces acute ...
https://www.cochin-poa.com/wp-content/uploads/2017/03/Article-17.pdf
In the K/BxN mouse serum transfer model, which mimics human inflammatory arthritis without lymphocyte influence, HO-1 was up-regulated by intraperitoneal ...
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33 Th17 in Animal Models of Rheumatoid Arthritis | HTML - MDPI
https://www.mdpi.com/2077-0383/6/7/73/htm
Although CD4 T cells were dispensable to arthritis induced by the injection of anti-GPI antibody (K/BxN serum transfer arthritis), autoreactive KRN CD4 T ...
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34 NIH Public Access - Carolina Digital Repository
https://cdr.lib.unc.edu/downloads/8049gd73b
Conclusion: S100A8 and S100A9 are not essential for disease expression in either the K/BxN serum transfer or the CIA model of inflammatory arthritis.
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35 Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum ...
https://archive-ouverte.unige.ch/unige:110653
Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory ...
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36 Immune-Mediated Arthritis and the HPA Axis - Arbor Assays
https://www.arborassays.com/immune-mediated-arthritis-and-the-hpa-axis/
In the second model, serum from the arthritic K/BxN mice was transferred to normal mice resulting in the induction of arthritis.
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37 1 Pain pathogenesis in rheumatoid arthritis - arXiv
https://arxiv.org/pdf/1903.04987
cell wall-induced arthritis, collagen antibody-induced arthritis, serum transfer from K/BxN transgenic mice and tumor necrosis factor (TNF)-transgene mice.
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38 Roles of mast cells in rheumatoid arthritis
https://www.kjim.org/m/makeCookie.php?url=/m/journal/view.php?number=170259
However, another study shows that there is no difference in the IL-17A positive synovial MCs in RA and OA [57]. In the K/BxN serum transfer RA ...
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39 A genome-engineered bioartificial implant for autoregulated ...
https://www.science.org/doi/pdf/10.1126/sciadv.abj1414
In the murine K/BxN model of inflammatory arthritis, ... served in response to the first K/BxN serum transfer. Ccl2-IL1Ra.
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40 The KRN mouse model of inflammatory arthritis - CORE
https://core.ac.uk/download/pdf/159148025.pdf
ously occurring disease in K/BxN mice. The main difference was that the serum transfer-induced arthritis was only transient. Joint inflammation starts to ...
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41 The K/BxN mouse model of inflammatory arthritis: theory and ...
https://experts.arizona.edu/en/publications/the-kbxn-mouse-model-of-inflammatory-arthritis-theory-and-practic
Mice expressing the KRN T cell receptor transgene and the MHC class II molecule A(g7) (K/BxN mice) develop severe inflammatory arthritis, and serum from ...
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42 Using the K/BxN mouse model of - TSpace
https://tspace.library.utoronto.ca/bitstream/1807/98631/1/12865_2019_Article_328.pdf
model of endogenous, chronic rheumatoid arthritis (RA). Result: Using the serum-transfer K/BxN model and the endogenous autoimmune model, amelioration of ...
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43 Disease severity in K/BxN serum transfer-induced arthritis is ...
https://cyberleninka.org/article/n/1230151
Transfer of purified arthritogenic IgG instead of complete K/BxN serum also resulted in similar arthritis severity in IL-33 KO and WT mice, excluding a ...
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44 Heme Oxygenase-1 Regulates the Progression of K/BxN ...
https://figshare.com/articles/dataset/Heme_Oxygenase_1_Regulates_the_Progression_of_K_BxN_Serum_Transfer_Arthritis__/115782/1
Table S1 - Heme Oxygenase-1 Regulates the Progression of K/BxN Serum Transfer Arthritis · Rita Brines · Nuria Maicas · María Luisa Ferrándiz ...
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45 Inflammatory arthritis can be reined in by CpG-induced DCâ ...
https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=1586&context=open_access_pubs
Some CpGs inhibit K/BxN serum-transferred arthritis. (A) Mean ankle thickening (left) or clinical score (right) of mice injected i.p. with.
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46 A novel anti‐inflammatory role for secretory phospholipase A2 ...
https://www.embopress.org/doi/10.1002/emmm.201000072
We employed the K/BxN serum-transfer model of autoimmune inflammatory arthritis to explore the contributions of group V sPLA2 to the pathophysiology of ...
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47 induced arthritis by binding to DR5/ TRAIL-R2 - eLife
https://elifesciences.org/articles/48840.pdf
with arthritis implied that the chemokine CX3CL1 may play an ... K/BxN serum transfer increased sFasL in the synovial fluid of WT and ...
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