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1 Dilantin, Phenytek (phenytoin) dosing, indications, interactions ...
https://reference.medscape.com/drug/dilantin-phenytek-phenytoin-343019
Status epilepticus. Load 10-15 mg/kg or 15-20 mg/kg at 25-50 mg/min, THEN; Maintenance: 100 mg IV/PO q6-8hr PRN; Administer IV slowly; not to exceed 50 mg/ ...
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2 Guideline for Phenytoin Dose Calculations - GGC Medicines
https://handbook.ggcmedicines.org.uk/guidelines/central-nervous-system/guideline-for-phenytoin-dose-calculations/
3. Maintenance dose of phenytoin ... Typical phenytoin doses are 3–5mg/kg/day. The first dose should be given 12–24 hours after the loading dose. Oral or ...
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3 Timing of maintenance phenytoin therapy after intravenous ...
https://pubmed.ncbi.nlm.nih.gov/1930417/
We devised a protocol using an 18 mg/kg loading dose of phenytoin with serial levels (obtained after 2,6,12 hours) and analyzed the results in 20 consecutive ...
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4 Intravenous Phenytoin for Status Epilepticus in Adults
http://www.leedsformulary.nhs.uk/docs/phenytoin%20administration%20guide.pdf
Levels for maintenance dose: Take a trough level 2 days after initiation, then again 3-5 days later. If no change in plasma level/albumin status, then ...
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5 Phenytoin Dosage Guide + Max Dose, Adjustments - Drugs.com
https://www.drugs.com/dosage/phenytoin.html
Maintenance dose: 100 mg orally 3 or 4 times a day; increases to 600 mg 3 times a day may be needed for some patients; For patients with ...
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6 Phenytoin (Oral Route) Proper Use - Mayo Clinic
https://www.mayoclinic.org/drugs-supplements/phenytoin-oral-route/proper-use/drg-20072875
Your doctor may increase your dose as needed. For patients in the clinic or hospital (except with a history of liver or kidney disease), a loading dose of 1000 ...
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7 Phenytoin dose calculations
https://tam.nhsh.scot/home/therapeutic-guidelines/nervous-system/seizures/phenytoin-dose-calculations/
Maintenance dose of phenytoin. Phenytoin typical oral doses are 3 to 5mg/kg/day. The first dose should be given 12 to 24 hours after the loading ...
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8 Phenytoin Sodium 50mg/ml Solution for Injection - (emc)
https://www.medicines.org.uk/emc/product/4326/smpc
The loading dose should be followed by maintenance doses of 100mg orally or intravenously every 6 to 8 hours. In neonates, it has been shown that absorption of ...
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9 DOSAGE FORMS AND STRENGTHS - Accessdata.fda.gov
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020450s039lbl.pdf
be necessary for the control of status epilepticus. • The loading dose should be followed by maintenance doses of either CEREBYX or phenytoin [see Dosage.
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10 NHS Tayside Phenytoin Prescribing and Monitoring Guideline ...
https://www.nhstaysideadtc.scot.nhs.uk/approved/guidance/Phenytoin%20Prescribing%20and%20Monitoring%20Guidline.pdf
INTRAVENOUS LOADING DOSE IN STATUS EPILEPTICUS. 4. 3. TOP UP DOSE FOR PATIENTS IN STATUS EPILEPTICUS. 5. BUT ALREADY ON PHENYTOIN. 4. MAINTENANCE PHENYTOIN ...
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11 Protocol for Intravenous Phenytoin for status epilepticus in adults
https://www.bedsformulary.nhs.uk/docs/Intravenous%20phenytoin%20protocol%20for%20status%20epilepticus%20in%20adults(V%201%202016).pdf
Check the drug history If a patient is taking phenytoin regularly they may not need to be loaded and may only require IV maintenance dose to be prescribed. In ...
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12 Status Epilepticus: The Role of Intravenous Phenytoin
https://jamanetwork.com/journals/jama/fullarticle/371755
Maintenance therapy with phenytoin should start at 4 to 7 mg/kg/day and be adjusted to both clinical response and serum levels. (JAMA 244:1479- ...
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13 The Complete (but Practical) Guide to Phenytoin Dosing
https://www.tldrpharmacy.com/content/the-complete-but-practical-guide-to-phenytoin-dosing
I'll just use 10 mg/kg moving forward to make things simple). A general scheme for maintenance dosing is 5-7 mg/kg/day, although this may be ...
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14 Pediatric Fosphenytoin Dosing Regimen in Status Epilepticus ...
https://www.neurologyadvisor.com/seizure-disorders/pediatric-fosphenytoin-dosing-regimen-status-epilepticus-seizure-clusters/
A fosphenytoin maintenance dose is most efficacious when started 12 hours following the loading dose in pediatric patients with status ...
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15 Phenytoin: Generic, Uses, Side Effects, Dosages ... - RxList
https://www.rxlist.com/consumer_phenytoin_dilantin_phenytek/drugs-condition.htm
Dosage Considerations – Should be Given as Follows: · Adult: Load 10-15 mg/kg or 15-20 mg/kg at 25-50 mg/min, THEN · Maintenance: 100 mg intravenously/orally ...
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16 Phenytoin – Loading Dose Guide (Adults) - Dorset Formulary
http://www.dorsetformulary.nhs.uk/docs/bnf04/RBCH%20PHT%20Phenytoin%20Loading%20dose%20guidelines.pdf
If a patient is already taking regular phenytoin (Epanutin) reliably they may not need to be loaded – go straight to IV maintenance dose below.
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17 Phenytoin Injection Dosage & Rx Info | Uses, Side Effects
https://www.empr.com/drug/phenytoin-injection/
Status epilepticus: IV not to exceed 50mg/min. Loading dose: 10–15mg/kg followed by maintenance doses of 100mg orally or IV every 6–8 hrs.
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18 Dilution Dilantin ®- Phenytoin - GlobalRPH
https://globalrph.com/dilution/dilantin-phenytoin/
The loading dose should be followed by maintenance doses of 100 mg orally or intravenously every 6-8 hours. In the pediatric population, a loading dose of 15-20 ...
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19 Typical dosing of antiseizure medications in adults with CKD
https://www.uptodate.com/contents/image/print?imageKey=NEPH%2F109485&topicKey=NEURO%2F2212&source=see_link
Phenytoin. 300 to 600 mg orally per day in two or three divided doses. Carefully individualize dose according to seizure control and serum concentrations, refer ...
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20 PHENYTOIN LOADING DOSE IN STATUS EPILEPTICUS
http://www.dickyricky.com/Medicine/Guidelines/RSH%20-%20Royal%20Shrewsbury%20Hospital/2013_02%20Phenytoin%20Loading.pdf
INTRAVENOUS PHENYTOIN. (Loading dosage in status epilepticus). INDICATIONS. •. Status epilepticus – for patients not taking maintenance phenytoin therapy ...
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21 Phenytoin Sodium - Starship
https://starship.org.nz/guidelines/phenytoin-sodium
Start maintenance 12 hours post loading dose. The maintenance dose needs to be monitored and adjusted according to response and blood levels.
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22 DBL Phenytoin Injection BP 50 mg/mL Solution for ... - Medsafe
https://www.medsafe.govt.nz/profs/datasheet/d/dblphenytoininj.pdf
Dose. Status epilepticus: For the control of status epilepticus in adults, ... by maintenance doses of 100 mg orally or intravenously every 6 to 8 hours.
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23 DILANTIN (phenytoin sodium) Injection - Pfizer
https://labeling.pfizer.com/ShowLabeling.aspx?id=14822
serum levels is advised when using phenytoin in the management of status epilepticus and in the subsequent establishment of maintenance dosage.
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24 Status Epilepticus - EMCrit Project
https://emcrit.org/ibcc/sz/
Recently there has been a trend towards using higher maintenance doses, with 1.5 grams q12 being used initially for most patients in status ...
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25 intravenous phenytoin - SA Health
https://www.sahealth.sa.gov.au/wps/wcm/connect/public+content/sa+health+internet/resources/policies/intravenous+phenytoin+-+sa+perinatal+practice+guidelines
Maintenance dose. References. Acknowledgements. Summary of Practice Recommendations. > IV phenytoin is used for emergency treatment for convulsive-status ...
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26 Phenytoin | Drugs - BNF - NICE
https://bnf.nice.org.uk/drugs/phenytoin/
Loading dose 20 mg/kg (max. per dose 2 g), then (by intravenous infusion or by slow intravenous injection or by mouth) maintenance 100 mg every 6–8 hours ...
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27 Management of Status Epilepticus | AAFP
https://www.aafp.org/pubs/afp/issues/2003/0801/p469.html
Phenobarbital typically is used after a benzodiazepine or phenytoin has failed to control status epilepticus. The normal loading dose is 15 ...
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28 Phenytoin: A Guide to Therapeutic Drug Monitoring
https://journals.sagepub.com/doi/pdf/10.1177/201010581302200307
Using normal maintenance doses, the drug commonly reaches a steady state in 7–10 days9. In emergency situations such as status epilepticus when phenytoin ...
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29 PHENYTOIN (Dilantin) - CW Online Formulary
http://www.pedmed.org/DrugApp/pedshowdrug.php?drugID=306
Status Epilepticus: IV loading dose: 20 mg/kg/dose IV (max: 1500 mg/dose). May give additional load of 5-10 mg/kg ...
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30 Status epilepticus guideline - The Walton Centre
https://www.thewaltoncentre.nhs.uk/Downloads/Information%20for%20healthcare%20professionals/Status%20Epilepticus%20Guidelines%20July%202020.pdf
Maintenance doses of antiepileptic drugs (commence 10-14 hours after ... If the patient is in status epilepticus and a recent plasma phenytoin level is ...
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31 Phenytoin Loading Dose Calculator - ClinCalc.com
https://clincalc.com/Phenytoin/LoadingDose.aspx
The basis of loading dose calculations involves a drug's volume of distribution (Vd). For phenytoin, a Vd of 0.7 L/kg is used. The following ...
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32 Phenytoin - WikEM
https://wikem.org/wiki/Phenytoin
Status epilepticus · Loading dose: 15-20mg/kg IV; if ineffective, can give 10mg/kg IV 20 min after first dose · Maintenance dose: 100mg PO/IV q 6- ...
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33 73fm.6 phenytoin information for prescribing, monitoring and
https://www.bucksformulary.nhs.uk/docs/Guideline_73FM.pdf
Control of status epilepticus (see guideline 595FM Management of Generalised Status ... Start maintenance 18 to 24 hours after loading dose.
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34 Peri-operative prophylaxis with phenytoin: Dosage and ...
https://link.springer.com/article/10.1007/BF01411737
PHT infusion rate never exceeded 30 mg/min. Six hours after the loading dose, PHT maintenance treatment (250 mg, i.V., every 8 hours) was started in all ...
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35 CEREBYX®Dosage and Administration (fosphenytoin sodium)
https://www.pfizermedicalinformation.com/en-us/cerebyx/dosage-admin
... of status epilepticus. The loading dose should be followed by maintenance doses of either CEREBYX or phenytoin [see Dosage and Administration (2.4)].
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36 Levetiracetam versus phenytoin for second-line ... - The Lancet
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30724-X/fulltext
Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; ...
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37 phenytoin sodium Pediatric Drug Monograph
https://www.wellrx.com/phenytoin%20sodium/pediactric-monographs/
-Do not use IM phenytoin for the treatment of status epilepticus or other ... Infants may require larger maintenance doses due to the enhanced hepatic ...
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38 Phenytoin (Injectable) for Adult Patients Guideline
https://www.wacountry.health.wa.gov.au/~/media/WACHS/Documents/About-us/Policies/Specialised-Medication---Phenytoin--Injectable--for-Adult-Patients-Guideline.pdf?thn=0
specialised drug interaction texts; Specialist and/or Clinical Pharmacist advice is to be considered. 2.6 Dosage. Status epilepticus (adult).
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39 Preventing phenytoin intoxication: Safer use of a familiar ...
https://cdn.mdedge.com/files/s3fs-public/Document/September-2017/5303JFP_AppliedEvidence.pdf
Phenytoin carries a special risk of dose-related ... initiating or increasing a maintenance dose. ... include status epilepticus; repeated new seizures.
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40 80: Phenytoin dosage, adjustment, and monitoring
https://www.pharmacyjoe.com/phenytoin-dosage-adjustment-and-monitoring/
The initial dose of phenytoin is a loading dose of 15-20 mg/kg, followed by a maintenance dose of 5-6mg/kg/day. How can I tell if the phenytoin ...
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41 phenytoin [OzEMedicine - Wiki for Australian Emergency ...
http://www.ozemedicine.com/wiki/doku.php?id=phenytoin
in status epilepticus, loading dose can be given over 30min, in less urgent situations, give over 60min. iv dose of phenytoin for certain ...
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42 Phenytoin vs Fosphenytoin
https://www.tandfonline.com/doi/pdf/10.1080/08998280.1999.11930167
1) For status epilepticus, a loading dose of 15-20 mg PE/kg isadministered at 100-150 mg PE/min. 2) Oral phenytoin should be used for maintenance if feasible.
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43 Phenytoin - Family Practice Notebook
https://fpnotebook.com/neuro/pharm/Phnytn.htm
Status Epilepticus. Dose: 20 mg/kg IV (at 1 mg/kg/min up to 50 mg/min) up to to 1000 mg maximum; May repeat once with Phenytoin 5-10 mg/kg IV; Maintenance ...
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44 PHENYTOIN (Dilantin) | LHSC
https://www.lhsc.on.ca/critical-care-trauma-centre/phenytoin-dilantin
PHENYTOIN (Dilantin) · Loading Dose: 14-18mg/kg IV direct · Maintenance Dose: 5mg/kg/day (in divided doses every 8 hours).
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45 Emergency treatment with levetiracetam or phenytoin in status ...
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-017-2010-8
Convulsive status epilepticus (CSE) is the most common ... Children receiving oral phenytoin or levetiracetam as maintenance therapy are ...
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46 MGH STATUS EPILEPTICUS TREATMENT PROTOCOL
https://seizure.mgh.harvard.edu/wp-content/uploads/MGH_Status_Protocol_01_09_2015.pdf
DIAGNOSIS OF STATUS EPILEPTICUS: 1) Generalized convulsive status epilepticus ... Continue maintenance anticonvulsants and adjust doses for therapeutic.
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47 82737396.pdf - CORE
https://core.ac.uk/download/pdf/82737396.pdf
Comparing paediatric intravenous phenytoin doses using ... dose of phenytoin in the treatment of paediatric convulsive status epilepticus (CSE) in the.
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48 IV Drugs in Status Epilepticus - Steve Evans' page
https://www.msevans.com/epilepsy/statusivdrugs.html
Fosphenytoin is given as an IV loading dose of 27 mg/kg (or 18 mg/kg in "phenytoin equivalents"), dissolved in IV fluid and infused at a rate of ...
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49 Fosphenytoin dosing regimen including optimal timing for the ...
https://www.brainanddevelopment.com/article/S0387-7604(22)00113-9/fulltext
In pediatric patients, a maintenance dose of fosphenytoin should be started 12 h after the loading dose, and a maintenance dose of 5–7.5 mg/kg/ ...
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50 Pharmacotherapy Update | Fosphenytoin (Cerebyx®)
https://www.clevelandclinicmeded.com/medicalpubs/pharmacy/novdec2004/fosphenytoin.htm
Patients enrolled in the IM fosphenytoin study received an initial loading dose of 8-12 mg PE/kg and maintenance therapy for 3-14 days. Patients enrolled in the ...
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51 ORAL DOSING REQUIREMENTS FOR PHENYTOIN IN THE ...
http://jptcp.com/index.php/jptcp/article/view/518
To achieve therapeutic serum phenytoin levels in infants, doses of 10-20 mg/kg/day are required. These higher doses can be safely administered ...
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52 Phenytoin and Fosphenytoin | Casebook in Clinical ...
https://accesspharmacy.mhmedical.com/content.aspx?bookid=1514§ionid=88805062
The recommended dose for adult patients in status epilepticus is 15–20 mg/kg. For maintenance doses, adults may be loaded at 15–20 mg/kg.
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53 Clinical Policy: Critical Issues in Evaluation and Management ...
https://todd-roat.squarespace.com/s/Guide-for-PO-loading-of-ASD_2020.pdf
An alternative option includes resuming home maintenance dose as prescribed. Drug. Non-Status Epilepticus. Loading Dose ... Dilantin, Phenytek.
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54 Loading Doses Again - Patient Safety Tip of the Week Archive
https://www.patientsafetysolutions.com/docs/March_2017_Loading_Doses_Again.htm
The ED physician ordered the correct loading dose of intravenous (IV) phenytoin, to be administered every 8 hours for 3 doses. But there was miscommunication ...
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55 Paediatric Infant Perinatal Emergency Retrieval : Phenytoin
https://www.rch.org.au/piper/neonatal_medication_guidelines/Phenytoin/
Loading dose: 15 mg/kg to 20 mg/kg ; Maintenance dose: ; VLBW, 2 mg/kg/dose 12 hourly ; Term, 4 to 5 mg/kg/dose 12 hourly ; Week 2 and over, 4 to 5 mg/kg/dose 6 ...
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56 Phenytoin: Indication, Dosage, Side Effect, Precaution - MIMS
https://www.mims.com/malaysia/drug/info/phenytoin?mtype=generic
Maintenance: 100 mg (PO or IV) given 6-8 hourly. Child: 15-20 mg/kg, at a rate not exceeding 1-3 mg/kg/min. ... Adult: Initially, 3-4 mg/kg daily or 150-300 mg ...
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57 Is levetiracetam superior to phenytoin in treating status ep...
https://journals.lww.com/ebp/fulltext/2018/03000/is_levetiracetam_superior_to_phenytoin_in_treating.20.aspx
If seizure activity was refractory after 10 minutes, patients received a loading dose of IV phenytoin 20 mg/kg, levetiracetam 25 mg/kg, or valproate (n=50 for ...
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58 Phenytoin (injection) - wikidoc
https://www.wikidoc.org/index.php/Phenytoin_(injection)
Phenytoin (injection) is an antiepileptic that is FDA approved for the treatment of generalized tonic-clonic status epilepticus and ...
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59 Phenytoin | Drug Index | Pediatric Oncall - Pediatric Oncall
https://www.pediatriconcall.com/drugs/phenytoin/872
Status epilepticus: Loading dose: 15-20 mg/kg IV as a single or in divided doses; may administer 5-10 mg/kg additionally 10 ...
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60 Guideline for the management of convulsive status epilepticus ...
https://bcmj.org/sites/default/files/BCMJ_53_Vol6_guideline.pdf
of status epilepticus have been found less likely to develop neuro- ... maintenance of adequate ventilation ... use of a smaller dose of phenytoin (5.
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61 Pharmacokinetics and clinical effects of phenytoin and ...
https://bpspubs.onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2003.01829.x
CSF: plasma phenytoin concentration ratio ranged from 0.12 to 0.53 (median = 0.28, n = 16). Status epilepticus was controlled in only 36% (4/11) ...
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62 PHENYTOIN SODIUM INJECTION, USP - FDA.report
https://fda.report/DailyMed/ab923d09-747d-4527-9bdf-2c807a5775d2
Phenytoin is an anticonvulsant which may be useful in the treatment of generalized tonic-clonic status epilepticus. The primary site of action appears to be ...
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63 Phenytoin Sodium Injection, USP - TaperMD
https://tapermd.com/bbw/Dilantin.pdf
without underlying cardiac disease or comorbidities and at recommended doses and infusion rates. Withdrawal Precipitated Seizure, Status Epilepticus.
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64 PHENYTOIN DOSING AND LEVEL MONITORING
https://adc.bmj.com/content/100/6/e1.11
... Phenytoin is a first-line anticonvulsant used for status epilepticus and ... In 37% of patients, the maintenance dose was started 12 hours after loading ...
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65 DBL PHENYTOIN INJECTION BP - GuildLink
https://secure.guildlink.com.au/gc/ws/pf/pi.cfm?product=pfppheni
levels is advised when using phenytoin in the management of status epilepticus and the subsequent establishment of maintenance dosage.
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66 Case Study IV
https://pharmacy.ufl.edu/files/2013/01/2005-CS4-5128-SOL.pdf
But in this case the clearance of phenytoin decreases as Cssave of phenytoin increases. Therefore, if the maintenance dose is increased, the levels raise ...
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67 Comparative Efficacy of IV Phenytoin, IV Valproate, and IV ...
https://www.j-epilepsy.org/journal/view.php?number=194
Status epilepticus (SE) is a common pediatric neurological emergency ... followed by maintenance dose of 5 mg/kg/day in two divided doses.
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68 Phenytoin - NHS Networks
https://www.networks.nhs.uk/nhs-networks/yorkshire-humber-neonatal-odn/guidelines-1/formulary/phenytoin
Status epilepticus. Dose. Loading dose (for phenytoin naïve patients only): 20mg/ ... Maintenance dose can be given by slow intravenous injection or orally.
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69 Intramuscular use of fosphenytoin: - Neurology
https://n.neurology.org/content/neurology/46/6_Suppl_1/24S.full.pdf
At present, status epilepticus is commonly treated with a combination of IV lorazepam to produce rapid seizure control and IV phenytoin for maintenance of.
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70 Seizures - MSF Medical Guidelines
https://medicalguidelines.msf.org/en/viewport/CG/english/seizures-16688992.html
Status epilepticus · Children 1 month and over and adults: one dose of 15 to 20 mg/kg administered over 20 minutes minimum and 60 minutes maximum · The ...
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71 Convulsive-tonic-clonic-Status-Epilepticus-in-Adults.pdf
https://www.embeds.co.uk/wp-content/uploads/2019/03/Convulsive-tonic-clonic-Status-Epilepticus-in-Adults.pdf
Status epilepticus, sodium valproate, levetiracetam, Epilim, Keppra. Version. 2 (October 2018) ... Loading and maintenance dosing for IV Phenytoin.
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72 Fosphenytoin - The Epilepsy Prescriber's Guide to ...
https://www.cambridge.org/core/books/epilepsy-prescribers-guide-to-antiepileptic-drugs/fosphenytoin/BD62CA1A707D026685C878DB486136FB
– Optimum seizure control is most likely to occur at plasma phenytoin concentrations of 10–20 mg/L (40–80 μmol/L); however, many patients in status epilepticus ...
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73 Dilantin Infatabs (phenytoin) dose, indications ... - PDR.Net
https://www.pdr.net/drug-summary/Dilantin-Infatabs-phenytoin-1814
The maintenance dose is 4 to 6 mg/kg/day IV, divided into 2 or more doses. Do not exceed an IV administration rate of 50 mg/minute. Use IV route only when oral ...
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74 Maintenance Anticonvulsant or Antiepileptic Therapy
https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-nervous-system/maintenance-anticonvulsant-or-antiepileptic-therapy
Drug levels are monitored 2 wk after initiation of therapy, 2 wk after any dosage change, and usually every 6–12 mo once seizure control is achieved. Serum ...
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75 Efficacy, Tolerability and Serum Phenytoin Levels after ...
https://www.indianpediatrics.net/mar2020/mar-218-221.htm
Conclusion: Intravenous fosphenytoin loading dose of 20 mg/kg is effective in controlling seizures in 88% of children with status epilepticus, with a good ...
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76 Antiepileptic Drug Therapy for Status Epilepticus
https://thejcn.com/DOIx.php?id=10.3988/jcn.2021.17.1.11
32 The serum phenytoin concentration measured 2 h after loading may help to guide the timing of its maintenance dose.33 The infusion rate should ...
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77 Phenytoin: Pediatric drug information - Ykhoa.org
https://ykhoa.org/d/topic.htm?path=phenytoin-pediatric-drug-information
Alternate dosing: AAP recommendation: IV: 10 mg/kg in a single dose; then begin maintenance therapy usually 12 hours after dose. Note: Phenobarbital is the ...
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78 Injectable phenytoin is available in the strength of 50mg/ml ...
https://secure.newcastlelaboratories.com/uploaded/5b6ac402d460b5.57856764.doc
Once loading for management of status epilepticus is complete a maintenance dose of 100mg can be given every 6 to 8 hours (either intravenously or orally) with ...
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79 Pharmacokinetic Phenytoin Problems - Boomer.org
https://www.boomer.org/c/php/pk3102a.php
c. Calculate the new maintenance daily dose of phenytoin chewable tablets with a desired Cpss of 12 mg/L using both patient-specific Vmax and Km ...
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80 Appendix 2 - Management of Status Epilepticus - elmmb
https://www.elmmb.nhs.uk/elmmb-formulary/joint-medicines-formulary/status-epilepticus/
Loading doses of phenytoin are often inadequate. The following dose, although outside SPC recommendations, is often more effective: 20mg/kg (1.5g for a 75 kg ...
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81 Phenytoin | Side Effects, Dosage, Uses, and More - Healthline
https://www.healthline.com/health/drugs/phenytoin-oral-capsule
Phenytoin oral capsule is used to treat tonic-clonic and complex partial seizures in people with epilepsy. It's available as a generic drug and as the ...
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82 Treatment of tonic-clonic status epilepticus - Epilepsy Society
https://epilepsysociety.org.uk/sites/default/files/2020-08/Chapter33Walker2015.pdf
If phenytoin or phenobarbitone has been used in emergency treatment, maintenance doses can be continued orally (through a nasogastric tube).
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83 Fosphenytoin Sodium - Fresenius Kabi USA
http://editor.fresenius-kabi.us/PIs/US-PH-Fosphenytoin-Inj-FK-451079J_Jan_2018_PI.pdf
of status epilepticus. • The loading dose should be followed by maintenance doses of either fosphenytoin sodium injection or phenytoin [see Dosage.
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84 Status Epilepticus - ACCP
https://www.accp.com/docs/ccsap/CCSAP_2017Book3_Sample_Chapter.pdf
IV = intravenous(ly); PE = phenytoin equivalents; PRIS = propofol-related infusion syndrome. Lorazepam. Phenytoin. Valproate. Levetiracetam. Intubated. Propofol.
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85 Status Epilepticus • LITFL • CCC Neurology
https://litfl.com/status-epilepticus/
Status Epilepticus · Phenytoin 15-20 mg/kg IV over 30 minutes or longer. should be used to terminate seizures as a sole agent, always with benzodiazepines ...
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86 Management of Status Epilepticus (SE)
http://agrotikosiatros.gr/documents/MSE-OSUWMC.pdf
If seizures continue after Fosphenytoin loading dose escalate to Urgent ... Long-term maintenance of seizure control ... Dosed in phenytoin equivalents.
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87 Note a Treatment algorithm for pediatric status epilepticus (SE ...
https://www.mainehealth.org/-/media/MaineHealth/PDFs/Clinical-Guidelines-and-Resources/Emergency-Medicine/Emergency-Medicine-Guidelines-and-Protocols/10318-Guideline-Evidence.pdf
RCT. Ia. 100 patients (38 under 18y/o) with diazepam-refractory SE received either IV phenytoin or IV Valproic Acid loading dose of 20mg/kg at 40mg/min. 88% had ...
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88 Levetiracetam Dosing Guideline
https://foi.avon.nhs.uk/download.aspx?did=20226
The administration and dilution of levetiracetam for loading dose differs to ... Emergency Treatment with Levetiracetam or Phenytoin in Status Epilepticus ...
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89 Phenytoin - AAP Publications - American Academy of Pediatrics
https://publications.aap.org/pediatriccare/drug-monograph/18/5548/Phenytoin
Status epilepticus; neonatal seizures: IV: 15 to 20 mg/kg in a single or divided dose, then begin maintenance therapy usually 12 hours after dose (Domonoske ...
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90 Fosphenytoin sodium: new drug to replace intravenous ... - Gale
https://go.gale.com/ps/i.do?id=GALE%7CA20003328&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=00979805&p=AONE&sw=w
Phenytoin sodium (Dilantin[R]) - Parke-Davis) is an agent used for the treatment of acute seizures and status epilepticus. When ...
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91 Intravenous phenytoin loading in patients after neurosurgery ...
https://europepmc.org/article/med/3359738
By means of Monte Carlo simulations an optimal dosing scheme for phenytoin loading has been calculated. Based on these results, a dose of 15 mg/kg divided into ...
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92 Levetiracetam versus phenytoin for second-line treatment of ...
https://siren.network/sites/default/files/docs/article_2-_eclipse_-_may_2019.pdf
two doses of benzodiazepine or the child's personalised ... convulsive status epilepticus is intravenous phenytoin in.
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93 Pharmacologic Management of Status Epilepticus
https://aacnjournals.org/aacnacconline/article/31/4/349/31235/Pharmacologic-Management-of-Status-Epilepticus
A loading dose can be followed by maintenance dosing of 4 to 6 mg phenytoin equivalents/kg/d in divided doses. The rate of administration ...
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94 Status Epilepticus - Children's Hospital Colorado
https://www.childrenscolorado.org/49ed56/globalassets/healthcare-professionals/clinical-pathways/status-epilepticus_external.pdf
Additional second-line agents (IV loads +/- maintenance dosing) - Levetiracetam, fosphenytoin, or phenobarbital. Discuss dosing recommendations with Neurology ...
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95 phenytoin Nursing Considerations & Management - RNpedia
https://www.rnpedia.com/nursing-notes/pharmacology-drug-study-notes/phenytoin/
Status epilepticus: 10–15 mg/kg by slow IV. For maintenance, 100 mg PO or IV q 6–8 hr. Higher doses may be required. Do not exceed an infusion rate of 50 mg/ ...
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