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1 Statistical significance or clinical significance? A researcher's ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477766/
The main difference between statistical and clinical significance is that the clinical significance observes dissimilarity between the two groups or the two ...
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2 Statistical Significance vs Clinical Significance - Sengi
https://sengiclinical.com/research-tips/105-statistical-clinical-significance
In clinical research, such as an investigator initiated trial, statistical significance helps us determine whether the results of a treatment group are ...
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3 Clinical Versus Statistical Significance in Studies of Thoracic ...
https://www.jto.org/article/S1556-0864(20)30477-9/fulltext
Studies can reach statistical significance but provide evidence that is not clinically meaningful, or results could not be statistically ...
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4 Statistical significance vs. clinical significance
https://s4be.cochrane.org/blog/2017/03/23/statistical-significance-vs-clinical-significance/
Before you answer, first let me clarify something: Clinical significance is the practical importance of the treatment effect, whether it has a ...
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5 Statistical Significance Versus Clinical Importance of Obser...
https://journals.lww.com/anesthesia-analgesia/fulltext/2018/03000/statistical_significance_versus_clinical.48.aspx
Whenever the confidence limits contain a clinically important effect, a clinically significant effect cannot be ruled out irrespective of the statistical ...
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6 Balancing statistical and clinical significance in evaluating ...
https://pmj.bmj.com/content/77/905/201
Clinical significance measures how large the differences in treatment effects are in clinical practice. Different measures have been devised. Relative risk is ...
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7 Differentiating statistical significance and clinical significance
https://www.myamericannurse.com/wp-content/uploads/2015/05/ant5-Research-421.pdf
bility or chance that the results are ... guide clinical practice. ... Statistical significance must always be established before clinical significance.
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8 Clinical Significance vs. Statistical Significance | Study.com
https://study.com/academy/lesson/clinical-significance-vs-statistical-significance.html
Clinical significance is a little bit different than statistical significance. It's also known as 'clinical importance,' and this might be a helpful way to ...
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9 Statistical, practical and clinical significance and Doctor of ...
https://onlinelibrary.wiley.com/doi/full/10.1111/nae2.27
Practical significance quantifies the impact of a treatment and refers to the degree to which variables are associated with one another and ...
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10 Clinical versus statistical significance Ranganathan P ...
https://www.picronline.org/article.asp?issn=2229-3485;year=2015;volume=6;issue=3;spage=169;epage=170;aulast=Ranganathan
In clinical research, study results, which are statistically significant are often interpreted as being clinically important. While statistical ...
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11 Clinical Significance - Statistics How To
https://www.statisticshowto.com/clinical-significance/
Clinical Significance vs. Statistical Significance · Statistical significance is associated with p-values and other repeatable, measurable statistics. · Clinical ...
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12 statistical vs clinical significance - YouTube
https://www.youtube.com/watch?v=fTjmY6wSzXY
Rich Simpson
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13 Statistical and clinical significance, and how to use confidence ...
https://www.sciencedirect.com/science/article/pii/S1036731410000378
Clinical significance is a decision based on the practical value or relevance of a particular treatment, and this may or may not involve statistical ...
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14 Statistical significance versus clinical relevance
https://academic.oup.com/ndt/article/32/suppl_2/ii6/2864900
A possible alternative related to the P-value is the confidence interval (CI). It provides more information on the magnitude of an effect and ...
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15 Statistical Significance Article - StatPearls
https://www.statpearls.com/ArticleLibrary/viewarticle/29464
Introduction. In research, statistical significance is a measure of the probability of the null hypothesis being true compared to the acceptable level of ...
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16 (PDF) Statistical and clinical significance, and how to use ...
https://www.researchgate.net/publication/42610049_Statistical_and_clinical_significance_and_how_to_use_confidence_intervals_to_help_interpret_both
Clinical significance is a decision based on the practical value or relevance of a particular treatment, and this may or may not involve ...
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17 What is clinical and statistical significance in nursing evidence ...
https://thenursingace.com/samples/what-is-clinical-and-statistical-significance-in-nursing-evidence-based-practice/
In this regard, statistical significance as a parameter in evidence based practice shows the extent or the likelihood that finding from research is true and ...
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18 The clinician's guide to p values, confidence intervals, and ...
https://www.nature.com/articles/s41433-021-01863-w
What a p-value cannot tell us, is the clinical relevance or importance of the observed treatment effects. [1]. Specifically, a p-value does ...
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19 The Importance of Power in Clinical Trials in Dermatology
https://jamanetwork.com/journals/jamadermatology/fullarticle/480877
A study that claims clinical relevance may lack sufficient statistical significance to make a meaningful statement. Conversely, a study that shows a ...
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20 P Values, Statistical Significance & Clinical Significance
https://www.uws.edu/wp-content/uploads/2013/10/P_Values_Statistical_Sig_Clinical_Sig.pdf
In health care research, it is generally agreed that we want there to be only a 5% or less probability that the treatment results, risk factor, ...
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21 The Ubiquitous p<.05: Practical versus Statistical Significance ...
https://www.facs.org/for-medical-professionals/news-publications/journals/rise/articles/rap-archive/the-ubiquitous-p-05-practical-versus-statistical-significance-revisited/
But to tell a good story, it has to make sense. This article is for the non-lover of statistics who wants to learn how statistical analysis can help to tell a ...
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22 Clinical Versus Statistical Significance: Interpreting P Values ...
https://journals.sagepub.com/doi/10.1177/0897190009358774
Clinical Versus Statistical Significance: Interpreting P Values and Confidence Intervals Related to Measures of Association to Guide Decision Making · Similar ...
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23 The Importance of Statistical and Clinical Significance
https://www.jandonline.org/article/S2212-2672(21)01431-3/fulltext
Clinical significance refers to the magnitude of the difference or relationship that will determine whether the results might affect clinical ...
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24 Why not to (over)emphasize statistical significance in
https://eje.bioscientifica.com/view/journals/eje/181/3/EJE-19-0531.xml
P values should not merely be used to categorize results into significant and non-significant. This practice disregards clinical relevance, ...
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25 Clinical vs statistical significance | Neurology
https://n.neurology.org/content/clinical-vs-statistical-significance
Clinical vs statistical significance ... the combination of aspirin-clopidogrel improves the 90-day functional outcome as compared to aspirin alone, ...
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26 Is it time to stop using statistical significance?
https://www.nps.org.au/australian-prescriber/articles/is-it-time-to-stop-using-statistical-significance
Clinical significance pertains to patient care. Deciding whether or not a study result is clinically significant cannot be determined by an ...
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27 An Easy Introduction to Statistical Significance (With Examples)
https://www.scribbr.com/statistics/statistical-significance/
The p value, or probability value, tells you the statistical significance of a finding. In most studies, a p value of 0.05 or less is considered ...
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28 Clinical Versus Statistical Significance - GitHub Pages
https://uopsych.github.io/psy611/readings/Sainani_2012.pdf
Many researchers focus so much on P values and statistical significance that they overlook ... This article gives readers tips for spotting results.
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29 Significance: Statistical or Clinical? | Prehospital and Disaster ...
https://www.cambridge.org/core/journals/prehospital-and-disaster-medicine/article/significance-statistical-or-clinical/97D9302DD4EA996A4CFE74D626A0CB3C
A statistically significant P value of .05 or less may or may not be of true clinical importance. In addition to data showing statistical ...
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30 Practical vs. Statistical Significance - Statistics By Jim
https://statisticsbyjim.com/hypothesis-testing/practical-statistical-significance/
Hypothesis tests with small effect sizes can produce very low p-values when you have a large sample size and/or the data have low variability. Consequently, ...
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31 statistical significance—too much of a good thing
https://www.annalsofoncology.org/article/S0923-7534(19)37428-9/fulltext
The use and interpretation of P values is a matter of debate in applied research. We argue that P values are useful as a pragmatic guide to interpret the ...
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32 Statistical vs Clinical Significance - Sportscience
https://www.sportsci.org/jour/0201/Statistical_vs_clinical.ppt
Statistical vs clinical, practical, or mechanistic significance. ... The smallest clinically beneficial and harmful values help define probabilities that ...
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33 What Does It Mean for Research to Be Statistically Significant?
https://www.cloudresearch.com/resources/guides/statistical-significance/what-is-statistical-significance/
Statistical significance is a measurement of how likely it is that the difference between two groups, models, or statistics occurred by chance or occurred ...
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34 Avoid the concept of 'statistical significance' when possible
https://www.graphpad.com/guides/prism/latest/statistics/statistical_significance_in_science.htm
Just because a difference is statistically significant does not mean that it is biologically or clinically important or interesting.
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35 There is life beyond the statistical significance
https://reproductive-health-journal.biomedcentral.com/articles/10.1186/s12978-021-01131-w
We recommend showing important clinical benefits with their confidence intervals in cases of point estimates compatible with results benefits ...
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36 5 things journalists need to know about statistical significance
https://journalistsresource.org/home/statistical-significance-research-5-things/
P-values range from 0 to 1. If a p-value falls under a certain threshold, researchers deem the pattern or relationship statistically significant ...
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37 Interpreting Outcomes 2—Statistical Significance and Clinical ...
https://www.jospt.org/doi/10.2519/jospt.2019.0704
Interpreting an outcome score involves making an informed judgment about what a change or difference of that size really means. This involves ...
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38 Practical vs. Statistical Significance: What's the Difference?
https://www.indeed.com/career-advice/career-development/practical-vs-statistical-significance
The p-values can help determine statistical significance in many different hypothesis tests, such as ANOVA, t-test and regression coefficients. Although it may ...
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39 Clinical Significance 1 Running Head - ERIC
https://files.eric.ed.gov/fulltext/ED499990.pdf
Effect size is a statistical method that quantifies the effect of a treatment or intervention in a research study by examining how much the statistics diverge.
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40 4 Things Healthcare Providers Should Know About P-Values ...
https://www.goodrx.com/hcp/providers/what-is-p-value-research
P-values only measure the statistical evidence for or against a hypothesis. They do not measure the clinical significance of the results. A ...
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41 Statistical significance - Optimizely
https://www.optimizely.com/optimization-glossary/statistical-significance/
Statistical significance is a measure of how unusual your experiment results would be if there were actually no difference in performance between your variation ...
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42 P value interpretations and considerations - Thiese
https://jtd.amegroups.com/article/view/9003/html
Scientific and clinical context is critical in differentiating statistical significance from clinical significance. A P value alone conveys little information ...
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43 What is statistical significance versus clinical significance?
https://www.simplifieddata.co.uk/what-is-statistical-significance-clinical-significance/
Clinical significance is similar. It's about looking at your results and seeing whether the effect size (your main estimate) actually means ...
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44 Tips for Busy Clinicians to Gauge Conclusions from Clinical ...
https://link.springer.com/article/10.1007/s11606-021-07037-4
To achieve statistical significance, the difference either needs to be sufficiently large, the sample size needs to be large, or the groups ...
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45 Ultimate MNT Impact: Understanding Statistical Significance ...
https://eatrightfnce.org/sessions/1970386/
Ultimate MNT Impact: Understanding Statistical Significance vs. Clinical Significance · Description · Learning Objectives: · Performance Indicators: · Speaker(s).
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46 Statistical significance - Institute for Work & Health
https://www.iwh.on.ca/what-researchers-mean-by/statistical-significance
Statistical significance refers to whether any differences observed between groups being studied are "real" or whether they are simply due to chance.
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47 Measures of Clinical Significance
https://www.jaacap.org/article/S0890-8567(09)62138-9/fulltext
). First, is an observed result real or should it be attributed to chance (i.e., statistical significance)? Second, if the result is real, how large ...
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48 Statistical vs. clinical significance - Teachers of EBHC
https://teachingebhc.org/learning-resource/statistical-vs-clinical-significance/
Statistical vs. clinical significance ... This cartoon by Hywel Williams says: The magnitude of benefit and adverse effects of new treatments are more important ...
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49 Statistical significance - Wikipedia
https://en.wikipedia.org/wiki/Statistical_significance
The term significance does not imply importance here, and the term statistical significance is not the same as research significance, theoretical significance, ...
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50 Statistical Significance vs. Clinical Importance of Results Essay
https://ivypanda.com/essays/statistical-significance-vs-clinical-importance-of-results/
However, it is critical to understand the main difference between them. A statistically significant result is based on the calculation of ...
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51 E 9 Statistical Principles for Clinical Trials Step 5
https://www.ema.europa.eu/en/documents/scientific-guideline/ich-e-9-statistical-principles-clinical-trials-step-5_en.pdf
3.3.2 Trials to Show Equivalence or Non-inferiority. ... also influenced by 'Guidelines on the Statistical Analysis of Clinical Studies' (March, 1992).
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52 Statistical Significance - Abstract - Europe PMC
https://europepmc.org/books/nbk459346
In research, statistical significance is a measure of the probability of the null hypothesis being true compared to the acceptable level of uncertainty ...
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53 Evidence-Based Practice Projects - Clinical & Statistical ...
https://onlinenursingpapers.com/evidence-based-practice-projects-clinical-statistical-significance-discussion-essay-assignment/
Incorporation of clinical significance can prove to be of great help in achieving this. Carrying out a clinical interpretation in the entire research process ...
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54 [PDF] "Statistical," "practical", and "clinical": How many kinds of ...
https://www.semanticscholar.org/paper/%22Statistical%2C%22-%22practical%22%2C-and-%22clinical%22%3A-How-of-Thompson/69b8cf3d735cb56254976860e1684d72472e33db
It is suggested that readers should expect authors to report indices of “practical” or “clinical” significance, or both, within their research reports; ...
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55 Quick Guide to Biostatistics in Clinical Research: Hypothesis ...
https://www.enago.com/academy/quick-guide-to-biostatistics-in-clinical-research-hypothesis-testing/
Usually, the level of statistical significance is set at 0.05. If the p- value is less than 0.05, then you would reject the null hypothesis ...
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56 Biological significance – Radiation Effects Research ...
https://www.rerf.or.jp/en/glossary/biols-en/
For example, a factor that causes a decrease in blood pressure of 1 mmHg on the average can be statistically significant if tested in a large group of people, ...
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57 EBM Toolkit | AAFP
https://www.aafp.org/pubs/afp/authors/ebm-toolkit.html
Also see this Point-of Care-Guide clinical decision rule table. Clinical vs. Statistical Significance. In a large study, a small difference may be statistically ...
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58 Clinical relevance vs. statistical significance
http://www.aulakinesica.com.ar/semioquirurgica/files/2011%20ATM.pdf
Clinical relevance vs. statistical significance: Using neck outcomes in patients with temporomandibular disorders as an example. Susan Armijo-Olivoa,b,c,*, ...
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59 New Guidelines for Statistical Reporting in the Journal | NEJM
https://www.nejm.org/doi/full/10.1056/nejme1906559
P values provide no information about the size of an effect or an association. The use of P values to summarize evidence in a study requires, on ...
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60 Confusing P-values with Clinical Impact: The Significance ...
https://towardsdatascience.com/the-significance-fallacy-confusion-about-p-values-d7b5e530d0c
Statistical significance is often confused with scientific importance or clinical impact. Remember that sample size does not correlate with ...
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61 Statistical Significance is dead – let's embrace uncertainty
https://dkf.unibas.ch/en/p-value/
The classification of study results into "statistically significant" versus "statistically non-significant" is no longer tenable. This is not only the opinion ...
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62 A Refresher on Statistical Significance
https://hbr.org/2016/02/a-refresher-on-statistical-significance
When you run an experiment or analyze data, you want to know if your findings are “significant.” But business relevance (i.e., practical ...
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63 A review of high impact journals found that misinterpretation of ...
https://www.jclinepi.com/article/S0895-4356(22)00021-X/fulltext
RCTs with non-statistically significant primary outcomes almost always present their conclusion in the abstract as evidence of no impact or ...
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64 Is it clinically significant? - The Lancet
https://www.thelancet.com/pdfs/journals/lancet/PIIS0140673602085562.pdf
or even the relevance of the variable under study. So much for statistical significance. It is well served, but what we need are tests of clinical ...
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65 Understanding Clinical Trials Statistics - OncologyPRO
https://oncologypro.esmo.org/content/download/72962/1300141/1/Tips-Tricks-Understanding-Clinical-Trials-Statistics.pdf
“Is the new treatment as good as the standard one?” H. 0. : “Different effect” or. “difference” in.
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66 Statistical significance: p value, 0.05 threshold, and ...
https://eurradiolexp.springeropen.com/articles/10.1186/s41747-020-0145-y
We highlight reasons for a conservative approach, as clinical research needs dichotomic answers to guide decision-making, in particular in the ...
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67 Moving to a World Beyond “p < 0.05” - Taylor and Francis
https://www.tandfonline.com/doi/full/10.1080/00031305.2019.1583913
Don't conclude anything about scientific or practical importance based on ... distinguishes between statistical and clinical significance.
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68 Statistical tests, P values, confidence intervals, and power
https://d-nb.info/1101591048/34
Clinical Epidemiology and Biostatistics Unit, Murdoch. Children's Research Institute ... The general definition of a P value may help one to.
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69 Numbers don't lie, but sometimes our brains do
https://www.fredhutch.org/en/news/center-news/2020/02/understanding-statistics.html
But understanding statistics is critical to weighing everyday risks, interpreting medical information and (perhaps less life-or-death) ...
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70 Statistical Significance in Table Ones - Cross Validated
https://stats.stackexchange.com/questions/422227/statistical-significance-in-table-ones
Covariate [differences] in Table One are not statistically significant because they are not prespecified hypotheses. And nobody would take you seriously ...
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71 The P value: What to make of it? A simple guide for ... - MDedge
https://www.mdedge.com/gihepnews/article/208601/mixed-topics/p-value-what-make-it-simple-guide-uninitiated/page/0/1
059), a difference of 30% seems clinically important. The difference between clinical and statistical significance can perhaps be better ...
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72 Statistical Significance | What is it and how to calculate
https://www.supersurvey.com/Significance
When a result is identified as being statistically significant, this means that you are confident that there is a real difference or ...
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73 Glossary | JAMA Guide to Statistics and Methods
https://jamaevidence.mhmedical.com/content.aspx?bookid=2742§ionid=233568704
The usual threshold for statistical significance (α) is 0.05. To perform a Bonferroni correction, one divides the critical P value by the number of comparisons ...
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74 Interpreting Research Findings with Confidence Interval
https://orthodontics-endodontics.imedpub.com/interpreting-research-findings-with-confidence-interval.pdf
which provide complementary information about the statistical probability and conclusions regarding the clinical significance of study findings [2].
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75 What a p-value tells you about statistical significance
https://www.simplypsychology.org/p-value.html
A p-value, or probability value, is a number describing how likely it is that your data would have occurred by random chance (i.e. that the null hypothesis is ...
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76 Statistical and Clinical Significance - Effect Size Calculators
https://lbecker.uccs.edu/clinsig
1. Statistical Significance. Statistical significance relates to the question of whether or not the results of a statistical test meets an accepted criterion ...
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77 Analyzing and Interpreting Data | Epidemic Intelligence Service
https://www.cdc.gov/eis/field-epi-manual/chapters/analyze-Interpret-Data.html
The analysis plan usually begins with the research questions or ... or clinical relevance might nonetheless be statistically significant.
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78 Statistical Significance - StudySmarter
https://www.studysmarter.us/explanations/psychology/scientific-investigation/statistical-significance/
Statistical significance can help psychologists decide if a type of mental health treatment is effective or not. This can help determine which practices to ...
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79 Predictive power of statistical significance
https://www.wjgnet.com/2222-0682/full/v7/i4/112.htm
Core tip: Statistical significance is currently defined as a P-value of 0.05 or less, however, this definition is inadequate because of the ...
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80 statistical vs. clinical significance - JSTOR
https://www.jstor.org/stable/41343965
is still 102.7°F. This example shows that statistical significance does not in and of itself help us in differentiating meaningful from trivial change. Further ...
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81 Multiple Endpoints in Clinical Trials Guidance for Industry | FDA
https://www.fda.gov/files/drugs/published/Multiple-Endpoints-in-Clinical-Trials-Guidance-for-Industry.pdf
hypertension showed a clear, statistically-significant advantage of losartan on the composite. 818 endpoint of death, nonfatal myocardial infarction, or stroke, ...
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82 Concise, Simple, and Not Wrong: In Search of a Short-Hand ...
https://www.frontiersin.org/articles/10.3389/fpsyg.2018.02185/full
Statistical significance refers to the conditional probability of hypothetical data. In the vast majority of cases where significance testing is ...
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83 Why say “statistically significant” rather than just ... - Surgery
https://www.surgjournal.com/article/S0039-6060(22)00613-4/fulltext
There are two reasons why “statistical” or “statistically” should always be used with the words “significance” or “significant” in scientific ...
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84 Statistics in Clinical Trials| Bioclever Blog
https://www.bioclever.com/statistics-in-clinical-trials-n-47-en
The p-value is based on the null hypothesis or starting point, which means that it is assumed that there is no difference between treated patients and untreated ...
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85 statistical significance - APA Dictionary of Psychology
https://dictionary.apa.org/statistical-significance
See also clinical significance; practical significance; significance level. ... test of significance in which more than two conditions are compared ...
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86 Which of the following is true of statistical significance and ...
https://www.numerade.com/ask/question/which-of-the-following-is-true-of-statistical-significance-and-clinical-significance-a-statistical-significance-is-more-important-than-clinical-importance-b-results-may-be-clinically-signifi-30587/
A. Statistical significance is more important than clinical importance B. Results may be clinically significant but not statistically significant C. Results ...
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87 Why proper understanding of confidence intervals and ...
https://www.mja.com.au/journal/2021/214/3/why-proper-understanding-confidence-intervals-and-statistical-significance
Second, in some trials it might be correct to conclude that a treatment is effective (or harmful), despite the non‐statistically significant ...
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88 Confidence Intervals Assess Both Clinical Significance and ...
https://www.acpjournals.org/doi/abs/10.7326/0003-4819-114-6-515
Not all statistically significant differences are clinically significant (1-3). Fortunately, confidence intervals can address both clinical ...
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89 Some Common Misperceptions About P Values | Stroke
https://www.ahajournals.org/doi/10.1161/STROKEAHA.114.006138
To declare statistical significance, we need a criterion. The α (also known as the type I error probability or the significance level) is that ...
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90 What Is the Meaning of "Statistical Significance"?
https://www.dhss.delaware.gov/dhss/dph/dpc/significance_layreader.html
For example, if a prevalence goes up by only 1 percentage point – and that is well within the confidence interval – we cannot say there has been any increase or ...
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91 P-Values on Trial: Selective Reporting of (Best Practice ...
https://hdsr.mitpress.mit.edu/pub/bd5k4gzf
Keywords: statistical significance, p values, data dredging, multiple testing, ASA guide to p values, selective reporting ...
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92 Poor statistical reporting, inadequate data presentation and ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202121
There was no evidence that reporting practices improved following publication of the editorial advice. Overall, 76-84% of papers with written ...
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93 Statistical versus clinical significance
https://www.jtcvs.org/article/S0022-5223(17)31874-3/fulltext
Statistical versus clinical significance ... either 5 doses of oral allopurinol (10 mg/kg/dose) or placebo at 12 hours before surgery; ...
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94 What are confidence intervals and p-values? - Bandolier
http://www.bandolier.org.uk/painres/download/whatis/What_are_Conf_Inter.pdf
One useful feature of confidence intervals is that one can easily tell whether or not statistical significance has been reached, just as in a hypothesis test.
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95 A Guide to Statistical Significance in EMS Research
https://www.hmpgloballearningnetwork.com/site/emsworld/article/220739/guide-statistical-significance-ems-research
Thus researchers think of statistical significance as a binary yes (p < 0.05) or no (p > 0.05) concept and avoid describing findings as “slightly significant” ( ...
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