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Google Keyword Rankings for : pcsk9 dallas heart study
1
A Spectrum of PCSK9 Alleles Contributes to Plasma Levels of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1380285/
The coding regions of PCSK9 were sequenced in the blacks and whites from the Dallas Heart Study (n=3,543) who had the lowest (<5th percentile) and highest ...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1380285/
The coding regions of PCSK9 were sequenced in the blacks and whites from the Dallas Heart Study (n=3,543) who had the lowest (<5th percentile) and highest ...
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2
PCSK9-inhibitor drug class that grew out of UTSW research ...
https://www.utsouthwestern.edu/newsroom/articles/year-2016/pcsk9-patient-khera.html
Using data from the Dallas Heart Study, a population-based study that gathered extensive medical data on 6,000 Dallas residents, ...
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https://www.utsouthwestern.edu/newsroom/articles/year-2016/pcsk9-patient-khera.html
Using data from the Dallas Heart Study, a population-based study that gathered extensive medical data on 6,000 Dallas residents, ...
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3
Taking On America's Biggest Killer | Discovery | Heart
https://utswmed.org/medblog/taking-americas-biggest-killer/
The Dallas Heart Study revealed that 1 in about every 50 African-Americans had a PCSK9 mutation. By 1999, Hobbs had established an independent ...
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https://utswmed.org/medblog/taking-americas-biggest-killer/
The Dallas Heart Study revealed that 1 in about every 50 African-Americans had a PCSK9 mutation. By 1999, Hobbs had established an independent ...
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4
Sequence Variations in PCSK9, Low LDL, and Protection ...
https://www.nejm.org/doi/full/10.1056/nejmoa054013
Background A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart disease (CHD), ...
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https://www.nejm.org/doi/full/10.1056/nejmoa054013
Background A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart disease (CHD), ...
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5
A Novel Loss of Function Mutation of PCSK9 Gene in White ...
https://www.ahajournals.org/doi/10.1161/01.atv.0000255311.26383.2f
In 2005 Cohen et al found that 2 inactivating mutations of PCSK9 (Y142X and C679X), present in 2% to 2.6% of blacks of the Dallas Heart Study, ...
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https://www.ahajournals.org/doi/10.1161/01.atv.0000255311.26383.2f
In 2005 Cohen et al found that 2 inactivating mutations of PCSK9 (Y142X and C679X), present in 2% to 2.6% of blacks of the Dallas Heart Study, ...
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6
Emerging LDL therapies: Using human genetics to discover ...
https://www.lipidjournal.com/article/S1933-2874(13)00066-4/pdf
Loss-of-function mutations in PCSK9 result in significantly decreased ... end of the LDL-C distribution in the Dallas Heart Study.
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https://www.lipidjournal.com/article/S1933-2874(13)00066-4/pdf
Loss-of-function mutations in PCSK9 result in significantly decreased ... end of the LDL-C distribution in the Dallas Heart Study.
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7
A conversation with Helen Hobbs - JCI
https://www.jci.org/articles/view/84086
She also discusses the initiation of the Dallas Heart Study and the development of a therapeutic inhibitor of PCSK9 for lowering LDL.
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https://www.jci.org/articles/view/84086
She also discusses the initiation of the Dallas Heart Study and the development of a therapeutic inhibitor of PCSK9 for lowering LDL.
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8
Genetic and Metabolic Determinants of Plasma PCSK9 Levels
https://academic.oup.com/jcem/article/94/7/2537/2597198
Design: We conducted an observational study in the Dallas Heart Study, a multiethnic, probability-based sample of Dallas County. Results: Plasma levels of PCSK9 ...
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https://academic.oup.com/jcem/article/94/7/2537/2597198
Design: We conducted an observational study in the Dallas Heart Study, a multiethnic, probability-based sample of Dallas County. Results: Plasma levels of PCSK9 ...
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9
The Dallas Heart Study Is Complete
https://swmedical.org/the-dallas-heart-study-complete/
Dallas Heart Study began in 1991. It would lead to discoveries of major genes and proteins that contribute to heart and metabolic disease.
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https://swmedical.org/the-dallas-heart-study-complete/
Dallas Heart Study began in 1991. It would lead to discoveries of major genes and proteins that contribute to heart and metabolic disease.
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10
Circulating PCSK9 levels and 2-hPG are positively correlated ...
https://lipidworld.biomedcentral.com/articles/10.1186/s12944-018-0658-z
PCSK9 levels increase as glucose metabolism deteriorated. ... The Dallas Heart Study [9] and our previous study [10] also showed that PCSK9 ...
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https://lipidworld.biomedcentral.com/articles/10.1186/s12944-018-0658-z
PCSK9 levels increase as glucose metabolism deteriorated. ... The Dallas Heart Study [9] and our previous study [10] also showed that PCSK9 ...
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11
How Genetic Validation Helped Innovate Medicine for Patients ...
https://www.amgen.com/stories/2022/08/how-genetic-validation-helped-innovate-medicine-for-patients-with-high-cholesterol
Independently, a group of researchers from Dallas Heart Study found that different mutations of PCSK9 could be correlated with lower LDL-C.8 ...
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https://www.amgen.com/stories/2022/08/how-genetic-validation-helped-innovate-medicine-for-patients-with-high-cholesterol
Independently, a group of researchers from Dallas Heart Study found that different mutations of PCSK9 could be correlated with lower LDL-C.8 ...
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12
PCSK9 as a Biomarker of Cardiovascular Disease
https://link.springer.com/10.1007/978-94-007-7741-5_20-1
In the Dallas Heart Study where plasma PCSK9 levels were measured in individuals with known mutations/polymorphisms, it was shown that LOF ...
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https://link.springer.com/10.1007/978-94-007-7741-5_20-1
In the Dallas Heart Study where plasma PCSK9 levels were measured in individuals with known mutations/polymorphisms, it was shown that LOF ...
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13
PCSK9-inhibitor drug class becomes a game-changer for ...
https://www.sciencedaily.com/releases/2016/02/160226081621.htm
Two of these drugs, in a category known as PCSK9 inhibitors, ... Using data from the Dallas Heart Study, a population-based study that ...
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https://www.sciencedaily.com/releases/2016/02/160226081621.htm
Two of these drugs, in a category known as PCSK9 inhibitors, ... Using data from the Dallas Heart Study, a population-based study that ...
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14
Common inactivating mutations in PCSK9 cause low LDL ...
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1399-0004.2005.0453a.x
These two mutations were then genotype in the entire population of the Dallas Heart Study, representing more than 3500 individuals from a ...
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https://onlinelibrary.wiley.com/doi/full/10.1111/j.1399-0004.2005.0453a.x
These two mutations were then genotype in the entire population of the Dallas Heart Study, representing more than 3500 individuals from a ...
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15
Genetics of PCSK9 - Simple Education
https://simpleeducation.co/moments/172/components/748/preview
Subjects with low LDL-C in the Dallas Heart Study had PCSK9 sequencing that identified two non-sense mutations in 2 % of the African American cohort resulting ...
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https://simpleeducation.co/moments/172/components/748/preview
Subjects with low LDL-C in the Dallas Heart Study had PCSK9 sequencing that identified two non-sense mutations in 2 % of the African American cohort resulting ...
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16
Update on PCSK9 Inhibitors - American College of Cardiology
https://www.acc.org/~/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/Meetings/2016/Course%20PDFs/Core%20Curriculum/Sat%20Post/Sat%206%2030%20am%20Byrne.pdf?la=en
Patients with atherosclerotic heart disease on maximally tolerated dose of statins with insufficient ... PCSK9 Mutations: Dallas Heart Study ...
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https://www.acc.org/~/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/Meetings/2016/Course%20PDFs/Core%20Curriculum/Sat%20Post/Sat%206%2030%20am%20Byrne.pdf?la=en
Patients with atherosclerotic heart disease on maximally tolerated dose of statins with insufficient ... PCSK9 Mutations: Dallas Heart Study ...
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17
How geneticist Helen Hobbs found a way to fight bad cholesterol
https://www.thehindu.com/sci-tech/health/how-geneticist-helen-hobbs-found-a-way-to-fight-bad-cholesterol/article26240901.ece
The cue for which gene to focus on in the Dallas Heart Study came from a ... The findings led to the development of the PCSK9 inhibitors ...
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https://www.thehindu.com/sci-tech/health/how-geneticist-helen-hobbs-found-a-way-to-fight-bad-cholesterol/article26240901.ece
The cue for which gene to focus on in the Dallas Heart Study came from a ... The findings led to the development of the PCSK9 inhibitors ...
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18
Dallas Heart Study Lipid Characteristics of Blacks With ...
https://slideplayer.com/slide/15752511/
Presentation on theme: "Dallas Heart Study Lipid Characteristics of Blacks With Nonsense Mutations in PCSK9"— Presentation transcript:.
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https://slideplayer.com/slide/15752511/
Presentation on theme: "Dallas Heart Study Lipid Characteristics of Blacks With Nonsense Mutations in PCSK9"— Presentation transcript:.
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19
Moderate Lifetime Reductions in LDL Cholesterol ...
https://www.hhmi.org/news/moderate-lifetime-reductions-ldl-cholesterol-dramatically-reduce-risk-heart-disease
Mutations in PCSK9, which contributes to degradation of the LDL receptor, ... A recent finding from the ongoing Dallas Heart Study, however, ...
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https://www.hhmi.org/news/moderate-lifetime-reductions-ldl-cholesterol-dramatically-reduce-risk-heart-disease
Mutations in PCSK9, which contributes to degradation of the LDL receptor, ... A recent finding from the ongoing Dallas Heart Study, however, ...
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20
Helen Hobbs - The Rockefeller University
https://www.rockefeller.edu/greengard-prize/recipients/hobbs/
Once again, she and Cohen turned to the Dallas Heart Study. This time they sought flaws in the PCSK9 gene among people with the lowest LDL cholesterol ...
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https://www.rockefeller.edu/greengard-prize/recipients/hobbs/
Once again, she and Cohen turned to the Dallas Heart Study. This time they sought flaws in the PCSK9 gene among people with the lowest LDL cholesterol ...
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21
Sex-specific predictors of PCSK9 levels in a European ...
https://www.atherosclerosis-journal.com/article/S0021-9150(20)30381-6/fulltext
On this matter, many studies in humans described PCSK9 plasma levels to ... et al. on the Dallas Heart Study (DHS) population (n = 3138) [.
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https://www.atherosclerosis-journal.com/article/S0021-9150(20)30381-6/fulltext
On this matter, many studies in humans described PCSK9 plasma levels to ... et al. on the Dallas Heart Study (DHS) population (n = 3138) [.
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22
The PCSK9 Problem: Is it Predictive, Punitive, or Puzzling?
https://www.jacc.org/doi/10.1016/j.jacasi.2021.10.003
Hypertension is a risk factor for stroke, CHD, coronary heart disease ... In the Dallas Heart Study, the association between PCSK9 and hsCRP ...
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https://www.jacc.org/doi/10.1016/j.jacasi.2021.10.003
Hypertension is a risk factor for stroke, CHD, coronary heart disease ... In the Dallas Heart Study, the association between PCSK9 and hsCRP ...
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23
PCSK9 loss-of-function variants and Lp(a) phenotypes among ...
https://www.jlr.org/article/S0022-2275(20)32292-6/fulltext
Genotyping for PCSK9 LOFVs was conducted in 10,196 black Reasons for ... The Dallas Heart Study reported higher levels of OxPL-apoB among ...
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https://www.jlr.org/article/S0022-2275(20)32292-6/fulltext
Genotyping for PCSK9 LOFVs was conducted in 10,196 black Reasons for ... The Dallas Heart Study reported higher levels of OxPL-apoB among ...
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24
Multiple rare variants in NPC1L1 associated with reduced ...
https://www.pnas.org/content/103/6/1810
NS sequence variations in NPC1L1 in Dallas Heart Study participants with low or ... multiple rare alleles in PCSK9 and NPC1L1 contributing to the phenotype.
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https://www.pnas.org/content/103/6/1810
NS sequence variations in NPC1L1 in Dallas Heart Study participants with low or ... multiple rare alleles in PCSK9 and NPC1L1 contributing to the phenotype.
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25
Bioinformatics, Genetics and Cholesterol: The Story of PCSK9
https://bridgeinformatics.com/bioinformatics-genetics-and-cholesterol-the-story-of-pcsk9/
The famous 2006 Dallas Heart Study identified commonalities between patients with low circulating LDL cholesterol levels and a lower risk of ...
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https://bridgeinformatics.com/bioinformatics-genetics-and-cholesterol-the-story-of-pcsk9/
The famous 2006 Dallas Heart Study identified commonalities between patients with low circulating LDL cholesterol levels and a lower risk of ...
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26
PCSK9 inhibition: A promise fulfilled?
https://www.ccjm.org/content/83/11_suppl_2/S36/tab-figures-data
Effect of PCSK9 inhibitors on cardiovascular events.50,51 ... Copenhagen General Population Study; CVD = cardiovascular disease; DHS = Dallas Heart Study; ...
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https://www.ccjm.org/content/83/11_suppl_2/S36/tab-figures-data
Effect of PCSK9 inhibitors on cardiovascular events.50,51 ... Copenhagen General Population Study; CVD = cardiovascular disease; DHS = Dallas Heart Study; ...
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27
PCSK9 Levels and Metabolic Profiles in Elderly Subjects with ...
https://www.mdpi.com/2077-0383/10/5/994
Statin therapy significantly increased the PCSK9 levels in NGT, PreDM and T2D ... In the Dallas Heart Study, the prevalence of the APOE polymorphism was ...
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https://www.mdpi.com/2077-0383/10/5/994
Statin therapy significantly increased the PCSK9 levels in NGT, PreDM and T2D ... In the Dallas Heart Study, the prevalence of the APOE polymorphism was ...
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28
A spectrum of PCSK9 alleles contributes to plasma levels of ...
https://scholars.uthscsa.edu/en/publications/a-spectrum-of-pcsk9-alleles-contributes-to-plasma-levels-of-low-d
The coding regions of PCSK9 were sequenced in the blacks and whites from the Dallas Heart Study (n = 3,543) who had the lowest (<5 th percentile) and ...
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https://scholars.uthscsa.edu/en/publications/a-spectrum-of-pcsk9-alleles-contributes-to-plasma-levels-of-low-d
The coding regions of PCSK9 were sequenced in the blacks and whites from the Dallas Heart Study (n = 3,543) who had the lowest (<5 th percentile) and ...
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29
PCSK9 inhibition and LDL cholesterol lowering
https://www.tandfonline.com/doi/pdf/10.2217/clp.12.74
of the Dallas Heart Study also documented that a common variant in PCSK9, R46L, was associated with lower LDL‑C levels in white.
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https://www.tandfonline.com/doi/pdf/10.2217/clp.12.74
of the Dallas Heart Study also documented that a common variant in PCSK9, R46L, was associated with lower LDL‑C levels in white.
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30
The Emerging Role of PCSK9 Inhibitors in Preventive ...
https://www.ecrjournal.com/articles/emerging-role-pcsk9-inhibitors-preventive-cardiology
At present, ongoing Phase III CVD outcome trials with PCSK9 inhibitors offer ... Subjects with low LDL-C in the Dallas Heart Study had PCSK9 ...
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https://www.ecrjournal.com/articles/emerging-role-pcsk9-inhibitors-preventive-cardiology
At present, ongoing Phase III CVD outcome trials with PCSK9 inhibitors offer ... Subjects with low LDL-C in the Dallas Heart Study had PCSK9 ...
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31
PCSK9: from molecular biology to clinical applications
https://journals.sagepub.com/doi/10.1177/0004563219864379
In keeping with these findings, PCSK9 concentrations are higher in those with obesity, or diabetes. However, the authors of the Dallas Heart derived PCSK9 study ...
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https://journals.sagepub.com/doi/10.1177/0004563219864379
In keeping with these findings, PCSK9 concentrations are higher in those with obesity, or diabetes. However, the authors of the Dallas Heart derived PCSK9 study ...
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32
Oral PCSK9 inhibitor found to be safe, effective to lower ...
https://newsroom.heart.org/news/oral-pcsk9-inhibitor-found-to-be-safe-effective-to-lower-cholesterol-in-first-human-trial
DALLAS, Nov. 15, 2021 — Results from two early clinical studies show the first version of an oral PCSK9-inhibitor cholesterol-lowering ...
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https://newsroom.heart.org/news/oral-pcsk9-inhibitor-found-to-be-safe-effective-to-lower-cholesterol-in-first-human-trial
DALLAS, Nov. 15, 2021 — Results from two early clinical studies show the first version of an oral PCSK9-inhibitor cholesterol-lowering ...
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33
Distribution of plasma LDL-C levels in African American ...
https://www.researchgate.net/figure/Distribution-of-plasma-LDL-C-levels-in-African-American-subjects-in-the-Dallas-Heart_fig1_8077738
Distribution of plasma LDL-C levels in African American subjects in the Dallas Heart Study without (top) and with (bottom) a nonsense mutation in PCSK9.
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https://www.researchgate.net/figure/Distribution-of-plasma-LDL-C-levels-in-African-American-subjects-in-the-Dallas-Heart_fig1_8077738
Distribution of plasma LDL-C levels in African American subjects in the Dallas Heart Study without (top) and with (bottom) a nonsense mutation in PCSK9.
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34
Further Cardiovascular Outcomes Research With PCSK9 ...
https://clinicaltrials.gov/ct2/show/NCT01764633
Cardiovascular death includes death resulting from an acute myocardial infarction (MI), sudden cardiac death, death due to heart failure (HF), ...
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https://clinicaltrials.gov/ct2/show/NCT01764633
Cardiovascular death includes death resulting from an acute myocardial infarction (MI), sudden cardiac death, death due to heart failure (HF), ...
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35
Rare Mutation Ignites Race for Cholesterol Drug
https://www.nytimes.com/2013/07/10/health/rare-mutation-prompts-race-for-cholesterol-drug.html
Her low-density lipoprotein, or LDL, the form that promotes heart ... the study had a single mutated PCSK9 gene that no longer functioned.
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https://www.nytimes.com/2013/07/10/health/rare-mutation-prompts-race-for-cholesterol-drug.html
Her low-density lipoprotein, or LDL, the form that promotes heart ... the study had a single mutated PCSK9 gene that no longer functioned.
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36
Innovations in Cardiovascular Health
https://ahahealthtech.org/strategic-initiatives/innovations-in-cardiovascular-health/
How Academic Medicine Propelled PCSK9 From Novel Finding to Therapeutic Target ... The Dallas Heart Study began in 1999 when Drs. Ronald Victor and Hobbs ...
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https://ahahealthtech.org/strategic-initiatives/innovations-in-cardiovascular-health/
How Academic Medicine Propelled PCSK9 From Novel Finding to Therapeutic Target ... The Dallas Heart Study began in 1999 when Drs. Ronald Victor and Hobbs ...
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37
Potential of PCSK9 as a new target for the management of ...
https://www.dovepress.com/potential-of-pcsk9-as-a-new-target-for-the-management-of-ldl-cholester-peer-reviewed-fulltext-article-RRCC
Keywords: proprotein convertase subtilisin/kexin type 9, PCSK9, ... In the Dallas Heart Study, two nonsense mutations (Tyr142X and Cys679X) ...
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https://www.dovepress.com/potential-of-pcsk9-as-a-new-target-for-the-management-of-ldl-cholester-peer-reviewed-fulltext-article-RRCC
Keywords: proprotein convertase subtilisin/kexin type 9, PCSK9, ... In the Dallas Heart Study, two nonsense mutations (Tyr142X and Cys679X) ...
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38
The Role of PCSK9 in Lipid Metabolism and its Relationship ...
http://www.ghrnet.org/index.php/jct/article/view/1223/1547
PCSK9 influence on cholesterol was evident in observational Dallas Heart Studies of multi-ethnic probability-based sample of Dallas ...
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http://www.ghrnet.org/index.php/jct/article/view/1223/1547
PCSK9 influence on cholesterol was evident in observational Dallas Heart Studies of multi-ethnic probability-based sample of Dallas ...
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39
UT Southwestern geneticist receives Breakthrough Prize
https://www.eurekalert.org/news-releases/740777
"The Dallas Heart Study, which she pioneered and has led for the ... mutations that changed the protein sequence of the PCSK9 gene led to ...
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https://www.eurekalert.org/news-releases/740777
"The Dallas Heart Study, which she pioneered and has led for the ... mutations that changed the protein sequence of the PCSK9 gene led to ...
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40
Cholesterol-Lowering PCSK9 Inhibitors Near Market Entry
https://cen.acs.org/articles/93/i13/Cholesterol-Lowering-PCSK9-Inhibitors-Near.html
A billion-dollar payday is a fine prize, to be sure, but PCSK9 inhibitors ... Hobbs and Cohen had been involved in the Dallas Heart Study, ...
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https://cen.acs.org/articles/93/i13/Cholesterol-Lowering-PCSK9-Inhibitors-Near.html
A billion-dollar payday is a fine prize, to be sure, but PCSK9 inhibitors ... Hobbs and Cohen had been involved in the Dallas Heart Study, ...
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41
Helen Hobbs, MD | Scholars - Harrington Discovery Institute
https://www.harringtondiscovery.org/scholars/helen-h-hobbs
She co-founded the Dallas Heart Study, a multi-ethnic, population-based study ... Her discovery that individuals with mutations in the PCSK9 gene not only ...
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https://www.harringtondiscovery.org/scholars/helen-h-hobbs
She co-founded the Dallas Heart Study, a multi-ethnic, population-based study ... Her discovery that individuals with mutations in the PCSK9 gene not only ...
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42
Sequence Variations in PCSK9, Low LDL, and Protection ...
https://bio.as.uky.edu/sites/default/files/Sequence%20variations.pdf
tor in the pathogenesis of coronary heart disease. (CHD). Population-based studies consistently dem- onstrate a positive correlation between ...
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https://bio.as.uky.edu/sites/default/files/Sequence%20variations.pdf
tor in the pathogenesis of coronary heart disease. (CHD). Population-based studies consistently dem- onstrate a positive correlation between ...
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43
Helen Hobbs - Wikipedia
https://en.wikipedia.org/wiki/Helen_Hobbs
Cohen found that people with hypomorphic PCSK9 mutations had lower LDL-cholesterol levels and were almost immune to heart disease. This finding led to the ...
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https://en.wikipedia.org/wiki/Helen_Hobbs
Cohen found that people with hypomorphic PCSK9 mutations had lower LDL-cholesterol levels and were almost immune to heart disease. This finding led to the ...
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44
The dawn of PCSK9 and PCSK9 inhibitors - Multidisciplinary
https://specialty.mims.com/topic/the-dawn-of-pcsk9-and-pcsk9-inhibitors-
Clinical studies have demonstrated that proprotein convertase ... PCSK9 gene in a subset of Afro-Americans from the Dallas Heart Study were ...
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https://specialty.mims.com/topic/the-dawn-of-pcsk9-and-pcsk9-inhibitors-
Clinical studies have demonstrated that proprotein convertase ... PCSK9 gene in a subset of Afro-Americans from the Dallas Heart Study were ...
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45
Trends in Utilization and Cost of Low-Density Lipoprotein ...
https://jamanetwork.com/journals/jamacardiology/fullarticle/2770174
PCSK9 inhibitor use and spending increased 144% and 199%, respectively, over the study period; an additional $2.5 billion could have been ...
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https://jamanetwork.com/journals/jamacardiology/fullarticle/2770174
PCSK9 inhibitor use and spending increased 144% and 199%, respectively, over the study period; an additional $2.5 billion could have been ...
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46
A CRISPR edit for heart disease - Document - Gale OneFile
https://go.gale.com/ps/i.do?id=GALE%7CA530226069&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=00280836&p=HRCA&sw=w
... naturally occurring mutations in PCSK9 could also have the effect of lowering LDL cholesterol. The researchers interrogated the Dallas Heart Study, ...
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https://go.gale.com/ps/i.do?id=GALE%7CA530226069&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=00280836&p=HRCA&sw=w
... naturally occurring mutations in PCSK9 could also have the effect of lowering LDL cholesterol. The researchers interrogated the Dallas Heart Study, ...
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47
PCSK9 loss-of-function variants and Lp(a ... - Europe PMC
https://europepmc.org/article/pmc/6824493
Genotyping for PCSK9 LOFVs was conducted in 10,196 black Reasons for Geographic ... The Dallas Heart Study reported higher levels of OxPL-apoB among black ...
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https://europepmc.org/article/pmc/6824493
Genotyping for PCSK9 LOFVs was conducted in 10,196 black Reasons for Geographic ... The Dallas Heart Study reported higher levels of OxPL-apoB among black ...
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48
PCSK9 Inhibitors: Clinical Relevance, Molecular Mechanisms ...
https://www.scielo.br/j/abc/a/CnT3TVf3jB8sbTQcW43PKKb/?lang=en
PCSK9 inhibition is capable of promoting a mean LDL reduction of up to 60%, ... The Dallas Heart Study found that PCSK9 levels were significantly higher in ...
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https://www.scielo.br/j/abc/a/CnT3TVf3jB8sbTQcW43PKKb/?lang=en
PCSK9 inhibition is capable of promoting a mean LDL reduction of up to 60%, ... The Dallas Heart Study found that PCSK9 levels were significantly higher in ...
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49
The fascinating story of PCSK9 inhibition: Insights ... - Healio
https://www.healio.com/news/cardiology/20150821/10_3928_1081_597x_20140101_08_1343305
... of LDL from the Dallas Heart Study. They found that a different genetic mutation causing PCSK9 deficiency led to lifelong reductions in ...
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https://www.healio.com/news/cardiology/20150821/10_3928_1081_597x_20140101_08_1343305
... of LDL from the Dallas Heart Study. They found that a different genetic mutation causing PCSK9 deficiency led to lifelong reductions in ...
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50
Oral PCSK9 inhibitor may significantly reduce LDL C levels
https://medicaldialogues.in/cardiology-ctvs/news/oral-pcsk9-inhibitor-may-significantly-reduce-ldl-c-levels-dallas-the-first-human-trial-85315
Low-density lipoprotein (LDL) cholesterol, popularly known as bad cholesterol is major cause of heart disease. LDL C causes build-up of ...
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https://medicaldialogues.in/cardiology-ctvs/news/oral-pcsk9-inhibitor-may-significantly-reduce-ldl-c-levels-dallas-the-first-human-trial-85315
Low-density lipoprotein (LDL) cholesterol, popularly known as bad cholesterol is major cause of heart disease. LDL C causes build-up of ...
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51
Circulating PCSK9 levels and 2-hPG are positively correlated ...
https://d-nb.info/1154689786/34
Besides lipid metabolism and atherosclerosis, several studies have emphasized a possible link between PCSK9 and glucose metabolism. The Dallas Heart Study [9] ...
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https://d-nb.info/1154689786/34
Besides lipid metabolism and atherosclerosis, several studies have emphasized a possible link between PCSK9 and glucose metabolism. The Dallas Heart Study [9] ...
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52
Dallas Heart Study Lipid Characteristics of Blacks ... - SlideServe
https://www.slideserve.com/hamish-cummings/dallas-heart-study-lipid-characteristics-of-blacks-with-nonsense-mutations-in-pcsk9
Dallas Heart Study Lipid Characteristics of Blacks With Nonsense Mutations in PCSK9. ARIC PCSK9 Loss-of-Function Mutations, LDL-C, ...
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https://www.slideserve.com/hamish-cummings/dallas-heart-study-lipid-characteristics-of-blacks-with-nonsense-mutations-in-pcsk9
Dallas Heart Study Lipid Characteristics of Blacks With Nonsense Mutations in PCSK9. ARIC PCSK9 Loss-of-Function Mutations, LDL-C, ...
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53
The discovery of PCSK9 inhibitors: A tale of creativity and ...
https://www.qscience.com/content/journals/10.5339/gcsp.2013.39?crawler=true
In contrast, findings from the Dallas Heart Study, showed that loss of function mutations in PCSK9 gene in a subset of Afro-Americans were associated with ...
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https://www.qscience.com/content/journals/10.5339/gcsp.2013.39?crawler=true
In contrast, findings from the Dallas Heart Study, showed that loss of function mutations in PCSK9 gene in a subset of Afro-Americans were associated with ...
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54
C-terminal Loop Mutations Determine Folding and Secretion ...
https://www.primescholars.com/articles/cterminal-loop-mutations-determine-folding-and-secretionproperties-of-pcsk9-93248.html
PCSK9; LDL receptor; Protein mis-folding; Protein secretion; AAV8 transfection ... Multiple studies, including the Dallas Heart Study, demonstrate PCSK9 ...
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https://www.primescholars.com/articles/cterminal-loop-mutations-determine-folding-and-secretionproperties-of-pcsk9-93248.html
PCSK9; LDL receptor; Protein mis-folding; Protein secretion; AAV8 transfection ... Multiple studies, including the Dallas Heart Study, demonstrate PCSK9 ...
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55
Association between plasma PCSK9 levels and 10-year ...
https://www.internationaljournalofcardiology.com/article/S0167-5273(16)30764-1/abstract
The Dallas Heart Study indicated that even plasma concentrations of PCSK9 and LDL-C correlate with each other, less than 10% of the variance ...
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https://www.internationaljournalofcardiology.com/article/S0167-5273(16)30764-1/abstract
The Dallas Heart Study indicated that even plasma concentrations of PCSK9 and LDL-C correlate with each other, less than 10% of the variance ...
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56
PCSK9 Plasma Concentrations Are Independent of GFR and ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146920
In two well characterized independent cohort studies, PCSK9 plasma ... line with findings from the community-based Dallas Heart Study [20].
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146920
In two well characterized independent cohort studies, PCSK9 plasma ... line with findings from the community-based Dallas Heart Study [20].
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57
PCSK9 gene: MedlinePlus Genetics
https://medlineplus.gov/genetics/gene/pcsk9/
The PCSK9 gene provides instructions for making a protein that helps regulate the amount of cholesterol in the bloodstream. Learn about this ...
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https://medlineplus.gov/genetics/gene/pcsk9/
The PCSK9 gene provides instructions for making a protein that helps regulate the amount of cholesterol in the bloodstream. Learn about this ...
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58
Lipids Series-PCS K9 Inhibitors - YouTube
https://www.youtube.com/watch?v=uYDG8vqK4Co
Feb 15, 2021
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https://www.youtube.com/watch?v=uYDG8vqK4Co
Feb 15, 2021
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59
Targeting the PCSK9 pathway: where do novel therapies fit in?
https://pace-cme.org/2022/10/05/targeting-the-pcsk9-pathway-where-do-novel-therapies-fit-in/
10' education - Oct. 5, 2022 - Ann Marie Navar, MD, PhD - Dallas, TX, USA. English ... PCSK9 mAb - mechanism of action 1:36; FOURIER and ODYSSEY trials 2:55 ...
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https://pace-cme.org/2022/10/05/targeting-the-pcsk9-pathway-where-do-novel-therapies-fit-in/
10' education - Oct. 5, 2022 - Ann Marie Navar, MD, PhD - Dallas, TX, USA. English ... PCSK9 mAb - mechanism of action 1:36; FOURIER and ODYSSEY trials 2:55 ...
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60
New drugs show promise for treating high cholesterol
https://www.cbsnews.com/news/new-class-of-drugs-treating-high-cholesterol/
Researchers say class of drugs called PCSK9 antibodies may one day be an ... effect on reducing heart attacks and overall mortality.
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https://www.cbsnews.com/news/new-class-of-drugs-treating-high-cholesterol/
Researchers say class of drugs called PCSK9 antibodies may one day be an ... effect on reducing heart attacks and overall mortality.
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61
PCSK9 in Myocardial Infarction and Cardioprotection - Frontiers
https://www.frontiersin.org/articles/10.3389/fphys.2020.602497/full
In the heart, studies in FAT/CD36 null mice have revealed that this protein is key to regulate the increase in the rate of FA metabolism ( ...
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https://www.frontiersin.org/articles/10.3389/fphys.2020.602497/full
In the heart, studies in FAT/CD36 null mice have revealed that this protein is key to regulate the increase in the rate of FA metabolism ( ...
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62
PCSK9 inhibitors - Heart UK
https://www.heartuk.org.uk/getting-treatment/pcsk9-inhibitors
In clinical studies, these medicines have lowered people's cholesterol levels by more than half and are proven to lower the risk of cardiovascular disease ( ...
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https://www.heartuk.org.uk/getting-treatment/pcsk9-inhibitors
In clinical studies, these medicines have lowered people's cholesterol levels by more than half and are proven to lower the risk of cardiovascular disease ( ...
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63
Are statins enough? When to consider PCSK9 inhibitors
https://www.health.harvard.edu/blog/are-statins-enough-when-to-consider-pcsk9-inhibitors-2020060819986
All patients in the study continued to take their statin medication. Researchers looked at the occurrence of CVD events (heart attack, stroke, ...
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https://www.health.harvard.edu/blog/are-statins-enough-when-to-consider-pcsk9-inhibitors-2020060819986
All patients in the study continued to take their statin medication. Researchers looked at the occurrence of CVD events (heart attack, stroke, ...
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64
PCSK9 inhibition: A game changer in cholesterol management
https://www.mayoclinic.org/medical-professionals/cardiovascular-diseases/news/pcsk9-inhibition-a-game-changer-in-cholesterol-management/mac-20430713
PCSK9 inhibitors fill a therapeutic niche for patients with familial hypercholesterolemia or ... Cardiovascular Diseases and Cardiac Surgery.
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https://www.mayoclinic.org/medical-professionals/cardiovascular-diseases/news/pcsk9-inhibition-a-game-changer-in-cholesterol-management/mac-20430713
PCSK9 inhibitors fill a therapeutic niche for patients with familial hypercholesterolemia or ... Cardiovascular Diseases and Cardiac Surgery.
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65
PCSK9 inhibitors – from discovery of a single mutation to a ...
https://www.archivesofmedicalscience.com/PCSK9-inhibitors-from-discovery-of-a-single-mutation-to-a-groundbreaking-therapy,63895,0,2.html
Hypercholesterolemia is one of the main risk factors for coronary heart ... well as the results of the most important studies concerning PCSK9 inhibitors.
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https://www.archivesofmedicalscience.com/PCSK9-inhibitors-from-discovery-of-a-single-mutation-to-a-groundbreaking-therapy,63895,0,2.html
Hypercholesterolemia is one of the main risk factors for coronary heart ... well as the results of the most important studies concerning PCSK9 inhibitors.
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66
Using PCORnet to Understand PCSK9 Inhibitor Use ... - PCORI
https://www.pcori.org/research-results/2017/using-pcornet-understand-pcsk9-inhibitor-use-among-patients-risk-heart-disease
Having high cholesterol levels raises a person's risk of getting heart disease. ... They wanted to learn whether the database had enough information to be ...
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https://www.pcori.org/research-results/2017/using-pcornet-understand-pcsk9-inhibitor-use-among-patients-risk-heart-disease
Having high cholesterol levels raises a person's risk of getting heart disease. ... They wanted to learn whether the database had enough information to be ...
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