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1 The Story Behind the First AIDS Drug - Time
AZT, or azidothymidine, was originally developed in the 1960s by a U.S. researcher as way to thwart cancer; the compound was supposed to ...
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2 The First AIDS Drugs | Center for Cancer Research
Azidothymidine (AZT), a compound first synthesized by Jerome Horowitz, Ph.D., in 1964 as an anti-cancer drug, was among the drugs initially tested. In a ...
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3 The History of FDA's Role in Preventing the Spread of HIV/AIDS
In March of 1987, FDA approved zidovudine (AZT) as the first antiretroviral drug for the treatment of AIDS. The high cost of the drug inhibited ...
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4 A brief history of AZT | National Museum of American History
AZT was approved by the FDA on March 19, 1987. It was approved in record time with only one trial on humans instead of the standard three and ...
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5 The History of HIV Treatment: Antiretroviral Therapy and More
Also called azidothymidine (AZT), the medication became available in 1987. Sold under the brand name Retrovir, AZT works by blocking proteins ...
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6 Zidovudine - Wikipedia
Zidovudine · Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medication · Common side effects include headaches, fever, and nausea.
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7 Researcher Jerome P. Horwitz, 93, created AZT, the first ...
Researcher Jerome P. Horwitz, 93, created AZT, the first approved treatment for HIV/AIDS.
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8 A Brief History of AZT, HIV's First 'Ray of Hope' - VICE
1996 was a definitive year, certainly, but HAART's development began in earnest nearly a decade before, with the fast-tracked FDA approval of ...
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9 30 Years Later, a Look at the First AIDS Drug - POZ Magazine
Also known as Retrovir or zidovudine, the compound AZT was not originally created with HIV in mind but was developed in the 1960s to battle ...
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10 Zidovudine's patent history - The Lancet
In November, 1984, zidovudine, first synthesised in 1964, was found to inhibit the replication of animal retroviruses in vitro. Predicting that ...
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11 AIDS Drug Creator Never Profited From His Discovery - NPR
› 2012/09/21 › aids-drug-creator-ne...
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12 AZT | drug - Encyclopedia Britannica
AZT, in full azidothymidine, also called zidovudine, drug used to delay development of AIDS (acquired immunodeficiency syndrome) in patients infected with ...
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13 HIV/AIDS: A Brief History of AZT – Part One - Gay in the 80s
AZT crystal in polarised light. AZT wasn't developed specifically for use against HIV. It was actually developed as an anti-cancer drug at the ...
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14 The rise and fall of AZT: It was the drug that had to work. It ...
› arts-entertainment › th...
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15 Zidovudine or Azidothymidine (AZT)
Before zidovudine was invented, scientists were trying to find a cure for cancer. In the 1960s, scientists theorized that environmental ...
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16 History of AIDS
In 1987, the first antiretroviral medication for HIV, azidothymidine (AZT), became available. Numerous other medications for ...
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The drug is azidothymidine, or AZT, an antiviral drug made by the Burroughs Wellcome Company under the brand name Retrovir. Its approval, which ...
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18 AIDS and the AZT Scandal: 1989 Feature - SPIN
“Yes, AZT is a form of chemotherapy,” says the man who invented the compound a quarter-century ago, Jerome Horwitz. “It is cytotoxic, and as ...
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19 AZT (zidovudine, Retrovir) -
AZT is used in combination with other anti-HIV drugs to treat (but not cure) HIV. ... found that only about 1% to 2% of people taking AZT develop anemia.
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20 A Timeline of HIV and AIDS -
... Administration (FDA) approves the first medication for AIDS—AZT (zidovudine)Exit Disclaimer an antiretroviraldrug initially developed to treat cancer.
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21 Claims that people were being killed by zidovudine (AZT ...
One time in the 80’s-90’s, people died from AZT and not the actual AIDS virus; Anthony Fauci pushed this treatment
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22 The History of HIV and AIDS in the United States - Healthline
Zidovudine, commonly known as AZT, was introduced in 1987 as the first treatment for HIV. Scientists also developed treatments to reduce transmission during ...
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23 Did Controversial AZT Treatment Kill More Patients than AIDS ...
Commonly called AZT, azidothymidine was originally produced to treat cancer two decades prior to the HIV epidemic.
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“We're very proud of the speed with which we developed AZT, says Burroughs Wellcome spokesperson Kathy S. Bartlett.
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25 Zidovudine | aidsmap
Zidovudine is manufactured under the trade name Retrovir by GlaxoSmithKline. Retrovir was the first drug licensed to treat HIV infection, having ...
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26 ZIDOVUDINE (AZT) 1. Exposure Data - IARC Publications
A colorimetric method of assay has been developed for anti-human immunodeficiency virus (HIV) agents, including zidovudine. Simultaneous quantifi-.
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27 Retrovir (AZT) Product Monograph - ViiV Healthcare
and efficacy of RETROVIR (AZT) in pediatric patients has been established; therefore, Health Canada has authorized indications applicable to ...
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28 A Different Kind of Drug War | Health Affairs
Arno and Feiden also reveal how zidovudine (AZT), developed from start to finish by National Cancer Institute (NCI) director Samuel Broder and his ...
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29 Avram Finkelstein | Enjoy AZT | The Metropolitan Museum of Art
Azidothymidine (or AZT), the first antiretroviral drug developed to treat HIV/AIDS, was approved for use in the general population by the United States Food ...
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30 AZT - Drug Information - Kaiser Permanente
Persons with AIDS have developed lactic acidosis and fatty liver while taking AZT and other drugs in its class. AZT can inhibit crucial DNA-related riboflavin ...
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31 Model Development and Scale-Up to Humans - ScienceDirect
A Physiologically Based Pharmacokinetic Model of Zidovudine (AZT) in the Mouse: ... The model was developed in the mouse and then scaled up to predict human ...
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32 HIV treatment evolution: drug development to meet modern ...
Treatments for HIV have come a long way since the first antiretroviral therapy (ART), zidovudine (AZT) – a nucleoside reverse transcriptase ...
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33 Plant compound more powerful than AZT against HIV
AZT, the first anti-HIV drug developed and marketed in 1987, and which remains the cornerstone of HIV drug cocktails today, inhibits this ...
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34 Who Found AZT Works for AIDS? - Science
built on trust. "Once you [begin a collabora- tion], you...tend to believe that person,". McDevitt told Science. "David didn't have.
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35 AIDS Treatment | UCSF Health
You and your doctor will work together to develop a treatment plan that best meets your needs. ... These drugs include Combivir (Zidovudine and Lamivudine), ...
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36 Witness History, AZT: The breakthrough treatment for Aids - BBC
In 1987 the first successful drug treatment was developed for Aids. AZT went from testing to approval in just over two years, the fastest approval in US ...
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37 Cross-Resistance between AZT, ddl and other Antiretroviral ...
from HIV-1-infected patients treated with AZT for vari- ous lengths of time were investigated. ... resistance to AZT developed more readily in patients at.
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38 AIDS drug AZT inventor and famed cancer scientist Jerome ...
AZT later became the first drug approved by the U.S. Food and Drug Administration for the treatment of HIV infection and AIDS.
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39 The Molecular Expressions Movie Gallery: AZT
In this respect, 3'-azidothymidine (also known as AZT, Retrovir® and Zidovudine) is probably the most effective anti-AIDS medication developed ...
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40 When Did HAART Become ART? - Verywell Health
It would take five years before the first antiretroviral drug, called AZT (zidovudine), was approved by the Food and Drug Administration ...
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41 Stop Giving People Toxic Drugs: HIV Does Not Cause AIDS
They developed severe symptoms following 3 weeks of treatment with AZT [1]. In addition to the failure of the antiviral drugs, AIDS patients ...
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42 The Truth About AZT - Chemistry and HIV - YouTube
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43 AZT – Health Information Library | PeaceHealth
HIV infected people with low vitamin B12 levels were shown in one study to be more likely to develop blood-related side effects (particularly anemia) from ...
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44 How HIV resists AZT: Virus hijacks a common molecule
About 10 years ago, biochemical studies in several laboratories established that AZT-resistant HIV-1 reverse transcriptase uses adenosine ...
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45 The history of ARVs: HIV treatment programmes - AllLife
AZT was seen as a breakthrough: the first medication that seemed to attack HIV, the virus itself. It was the first real hope for people infected with HIV, which ...
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46 The first, the next, and the cinematographed versions of AZT
In real life, at the time the movie begins, in 1985, AZT was still being developed, and it was only made available for patients undergoing clinical trials.
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47 Discovery and Development of Zidovudine as the Cornerstone ...
In her research department at Wellcome Research Laboratories, Dr. Gertrude B. Elion established a multidisciplinary team approach to antiviral drug development.
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48 The Ryan White HIV/AIDS Program - A Living History 1994
AZT is Found to Protect Newborns from HIV ... Recommendations for the use of the regimen in women and infants were developed and published in August 1994.
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49 zidovudine (Rx) - Medscape Reference
Medscape - HIV infection dosing for Retrovir, ZDV (formerly AZT) ... dose interruption may be required in patients who develop anemia or neutropenia.
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50 3.1 Marty St. Clair: Discovery of AZT as the First Anti-HIV Drug
The activity of AZT was first discovered November 16th, 1984. We started a Phase I safety study July 3rd, 1985. The first 19 patients were reported in Lancet ...
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51 When used with AZT, ddI and perhaps ddC, can delay HIV ...
Zidovudine (AZT) was the first antiretroviral drug used in HIV and AIDS. It is expensive and has several adverse effects including nausea, ...
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52 Hegemony: The Controversy over - Perinatal AZT Trials in Africa
Abstract: Research on zidovudine (AZT) for pregnant women in Africa sparked ... B, developed in Senegal, was unavailable there due to its high cost (Specter.
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53 Retrovir IV (Zidovudine Injection): Uses, Dosage, Side ... - RxList
In patients who develop significant anemia, dose interruption does not necessarily eliminate the need for transfusion. If marrow recovery occurs following dose ...
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54 Remembering Dr. Jerome Horwitz and AZT
In 1992, Burroughs Wellcome reported sales of $400 million for AZT, generating an enormous surge of profit for a drug that was developed and ...
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55 THE INSIDE STORY OF THE AIDS DRUG For the first time ...
In 1987, just three years after scientists learned what caused AIDS, the company won government approval for AZT -- the first and still the only ...
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56 AZT - World of Molecules
Zidovudine was the first drug approved for the treatment of AIDS and HIV infection. Jerome Horwitz of Barbara Ann Karmanos Cancer Institute and ...
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57 Newsroom CDC Report Shows Sharp Drop in AIDS in Infants
Increased use of perinatal zidovudine (AZT) therapy by HIV-infected pregnant ... (AHCPR) also developed and released educational materials for health care ...
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for children is being developed, with approval expected in mid-2020. ... 3TC: lamivudine; ABC: abacavir; AZT: zidovudine; DTG: dolutegravir; ...
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59 Magnitude and associated factors of anemia among AZT ...
A total of 320 adult AZT based HAART experienced HIV/AIDS patients' ... individuals in the pre AIDS stage of the disease develop anemia, ...
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60 The Toxicity of Azidothymidine (AZT) in the Treatment of ...
Anemia with hemoglobin levels below 7.5 g per deciliter developed in 24 percent of AZT recipients and 4 percent of placebo recipients (P<0.001).
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61 AZT: The breakthrough treatment for Aids Witness History
In 1987 the first successful drug treatment was developed for Aids. AZT went from initial test to approval in just over two years - at the time it was the ...
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62 HIV Pathogenesis and Drug Resistance - Scripps Research
The first antiretroviral was AZT, a type of chemical known as a nucleoside analogue, which targets the HIV enzyme called reverse transcriptase.
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63 AZT- the first drug treatment for HIV -
Despite the uncertainties, identification of the virus meant that a blood test for the AIDS virus could be developed, and vaccination was a ...
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64 AZT Trial - Wiki Journal Club
The 1987 AZT Trial included 282 mostly male HIV-positive patients with AIDS, defined by a single event of PCP pneumonia or AIDS-related complex ...
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65 Combination Antiretroviral Therapy for HIV Infection - AAFP
The first of these agents, zidovudine (AZT, ZDV; Retrovir), became available in 1987. Since that time, four additional agents have been licensed ...
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66 People and Discoveries: Drugs developed for leukemia - PBS
Elion retired in 1983 and within a year her former unit used her methods to develop AZT, the first drug licensed in the United States to treat HIV.
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67 The safety and efficacy of zidovudine (AZT) in the treatment of ...
The median duration of follow-up was 11 months. Measurements and main results: Fifty-one subjects developed the acquired immunodeficiency syndrome (AIDS), ...
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68 Zidovudine (Retrovir, AZT) - TheBody
Zidovudine was approved in 1987 as an antiretroviral (ARV) drug for people with HIV infection. Recommended dosages are available for children ...
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69 Zidovudine: MedlinePlus Drug Information
Zidovudine may decrease the number of certain cells in your blood, including red and white blood cells. Tell your doctor if you have or have ...
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70 Why Do HIV-1 and HIV-2 Use Different Pathways to Develop ...
However, clinical data suggest that when HIV-2 is challenged with AZT, it usually accumulates resistance mutations that cause AZT resistance by ...
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71 History of HIV/AIDS - CANFAR
Anti-retroviral drug, AZT Approved ... UNAIDS established “Fast Track” targets to dramatically scale-up HIV prevention and treatment programs to avert 28 ...
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RETROVIR (AZT) in combination with certain antiretroviral agents has ... (AZT) develops unexplained tachypnea, dyspnea, or a fall in serum ...
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73 How Indian pharma giant Cipla made AIDS drugs affordable
In 1991, Rama Rao, the research head of an Indian government laboratory, told Hamied that he had developed a chemical synthesis of AZT, ...
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74 AIDS Drug Trial |
› video › aids-drug-trial
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75 CTN 002: ddI, continued AZT - Canadian HIV Trials Network
Nine new AIDS-defining illnesses developed during the study; all but one were in the AZT group. A change to ddI led to a significant increase in CD4 counts ...
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76 ZIDOVUDINE (AZT) - ORAL (Retrovir) side effects, medical ...
Low white blood cells can make you more likely to get serious (sometimes fatal) infections. Seek immediate medical attention if you develop signs of infection ...
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77 HIV and AIDS: An Origin Story -
Originally a chemotherapy drug, AZT worked so well during its trial that ... had slowed the rate of HIV infection in developed countries, ...
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78 How was the antiretroviral drug zidovudine (AZT) treatment ...
AZT was initially developed as an anti-cancer agent in the 1960s. At the time it was thought that retroviruses cause cancers in humans.
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79 Jerome P. Horwitz | AZT developer, 93
Jerome P. Horwitz, 93, a scientific researcher who created AZT in 1964 in the hope that it would cure cancer but who entered the medical ...
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80 A Treatment IND for Retrovir Brand Zidovudine (AZT) Therapy ...
To facilitate the use of zidovudine (AZT) in children who are 3 months to 12 years of age who are HIV-infected and either symptomatic or have a CD4 cell ...
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81 Zidovudine Retrovir - Treatment - National HIV Curriculum
The doses of zidovudine administered in this study produced zidovudine exposures approximately 3 times the estimated human exposure at ...
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82 Through time: the breakthroughs changing the course of HIV ...
Originally developed as an anti-cancer drug, National cancer Institute scientists discovered its potency and efficacy in patients with HIV and ...
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83 Treating AIDS The drug AZT was the first drug that seemed ...
had developed AIDS. a. Do the data provide convincing evidence at the level that taking AZT lowers the proportion of infected people like the ones in this study.
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84 Zidovudine | Drugs - BNF - NICE
View zidovudine information, including dose, uses, side-effects, renal impairment, pregnancy, contra-indications, monitoring requirements and directions for ...
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85 The (actual and scientifically derived) healing power of the sea
Azidothymidine (or AZT) was the first ever antiretroviral approved treatment for HIV. Its release in 1987 was watershed, ...
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86 Nucleoside Reverse Transcriptase Inhibitor (NRTI) Associated ...
the NRTI drug class, zidovudine (AZT) and stavudine (d4T) are ... received AZT developed macrocytosis compared to none of the 137.
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87 Generic AZT Hits the United States - Pharmaceutical Executive
On Sept. 19, FDA approved four different generic versions of Retrovir (zidovudine), known as AZT, manufactured by three different companies, for ...
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88 Zidovudine-Induced Anemia in HIV/AIDS
... was on regular treatment with Zidovudine (AZT), Lamivudine (3TC) and Nevirapine (NVP) for the past 2 months developed with the complaints of vomiting, ...
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89 End of Chapter Questions - Pearson
Since an HIV population already has heritable variation for resistance to AZT before exposure to AZT, some patients would quickly develop resistant HIV strains ...
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90 Development of the First AIDS Drugs: AZT and Other ...
On March 19, 1987, zidovudine (3′-azido-2′3′dideoxythymidine, azidothymidine, AZT) was approved by the United States Food and Drug ...
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91 Neonatal AZT Instructions - Perinatal HIV Hotline
This patient handout, developed by the Illinois Perinatal HIV Hotline, is designed to assist parents/caretakers in administering neonatal AZT (Zidovudine, ...
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92 When It Comes to HIV Treatment, We've Come a Long Way ...
But then, after over a decade of toxic AZT meds often hurting ... In the mid-1990s, scientists developed antiretroviral drugs that were ...
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93 Retrovir (zidovudine) - GSKPro for Healthcare Professionals
be given to replacing zidovudine in established combination HIV-1/HCV therapy, especially in patients with a known history of zidovudine-induced anemia.
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94 2-in-1 LPV/r pellets and ABC/3TC or AZT/3TC | DNDi
In 2015, following the tentative approval by the US Federal Drug Administration of the lopinavir/ritonavir pellets developed by Cipla Ltd. (India), ...
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95 Synthesis and antiretroviral evaluation of derivatives ... - SciELO
However, despite the worldwide attempts underway to develop chemotherapeutic agents effective against HIV, 3'-azido-2',3'-dideoxythymidine (zidovudine, AZT, 1), ...
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96 Jerome Horwitz: 5 Surprising Facts About the Inventor of AZT
When Horwitz developed AZT, the drug initially was viewed as a failure. Back in 1964, the HIV virus hadn't even been discovered.
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97 Wellcome under fire over 'old' AZT data | New Scientist
Wellcome, the maker of the AIDS drug zidovudine (AZT), ... that the drug makes no difference to the time it takes for people to develop
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