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Google Keyword Rankings for : flap inhibitors treatment inflammatory diseases
1
FLAP inhibitors for the treatment of inflammatory diseases
https://pubmed.ncbi.nlm.nih.gov/19876784/
FLAP inhibitors such as MK-886, MK-0591 and veliflapon (BAY-X-1005, DG-031) demonstrated promise in clinical trials with patients with inflammatory diseases ...
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https://pubmed.ncbi.nlm.nih.gov/19876784/
FLAP inhibitors such as MK-886, MK-0591 and veliflapon (BAY-X-1005, DG-031) demonstrated promise in clinical trials with patients with inflammatory diseases ...
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2
5-lipoxygenase-activating protein inhibitors for inflammatory ...
https://www.cell.com/trends/pharmacological-sciences/pdf/S0165-6147(07)00287-8.pdf
Several FLAP inhibitors showed efficacy in early clinical trials in asthma but were not developed commercially for unpub- lished reasons. ...
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https://www.cell.com/trends/pharmacological-sciences/pdf/S0165-6147(07)00287-8.pdf
Several FLAP inhibitors showed efficacy in early clinical trials in asthma but were not developed commercially for unpub- lished reasons. ...
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3
Arachidonate 5 Lipoxygenase Activating Protein Inhibitor
https://www.sciencedirect.com/topics/medicine-and-dentistry/arachidonate-5-lipoxygenase-activating-protein-inhibitor
The effects of a FLAP inhibitor (DG-031, deCode genetics, Reykjavik, Iceland) on inflammatory biomarkers were examined in a short-term, randomized, ...
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https://www.sciencedirect.com/topics/medicine-and-dentistry/arachidonate-5-lipoxygenase-activating-protein-inhibitor
The effects of a FLAP inhibitor (DG-031, deCode genetics, Reykjavik, Iceland) on inflammatory biomarkers were examined in a short-term, randomized, ...
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4
Discovery of the first dual inhibitor of the 5-lipoxygenase ...
https://www.nature.com/articles/srep42751
FLAP inhibition abolishes LT formation exerting anti-inflammatory effects. The soluble epoxide hydrolase (sEH) converts AA-derived anti- ...
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https://www.nature.com/articles/srep42751
FLAP inhibition abolishes LT formation exerting anti-inflammatory effects. The soluble epoxide hydrolase (sEH) converts AA-derived anti- ...
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5
FLAP inhibitors for the treatment of inflammatory diseases
https://www.researchgate.net/publication/38055226_FLAP_inhibitors_for_the_treatment_of_inflammatory_diseases
FLAP inhibitors such as MK-886, MK-0591 and veliflapon (BAY-X-1005, DG-031) demonstrated promise in clinical trials with patients with inflammatory diseases in ...
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https://www.researchgate.net/publication/38055226_FLAP_inhibitors_for_the_treatment_of_inflammatory_diseases
FLAP inhibitors such as MK-886, MK-0591 and veliflapon (BAY-X-1005, DG-031) demonstrated promise in clinical trials with patients with inflammatory diseases in ...
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6
FLAP inhibitors for the treatment of inflammatory diseases ...
https://www.semanticscholar.org/paper/FLAP-inhibitors-for-the-treatment-of-inflammatory-Sampson/e200fbacb1931da7dd3cd263f9b3b5e7ade70640
Leukotrienes are lipid inflammatory mediators that are implicated in asthma, COPD, ... FLAP inhibitors for the treatment of inflammatory diseases.
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https://www.semanticscholar.org/paper/FLAP-inhibitors-for-the-treatment-of-inflammatory-Sampson/e200fbacb1931da7dd3cd263f9b3b5e7ade70640
Leukotrienes are lipid inflammatory mediators that are implicated in asthma, COPD, ... FLAP inhibitors for the treatment of inflammatory diseases.
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7
Polypharmacology of Small-Molecule Modulators of the 5 ...
https://www.slas-discovery.org/article/S2472-5552(22)07068-X/pdf
the target for the treatment of inflammation, asthma, pain, cardiovascular diseases, and cancer. ... binding target of LT synthesis inhibitor, MK-886,4 FLAP.
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https://www.slas-discovery.org/article/S2472-5552(22)07068-X/pdf
the target for the treatment of inflammation, asthma, pain, cardiovascular diseases, and cancer. ... binding target of LT synthesis inhibitor, MK-886,4 FLAP.
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8
Molecular Pharmacology of Inflammation Resolution in ... - MDPI
https://www.mdpi.com/1422-0067/23/9/4808/htm
Attempts to find applications of FLAP inhibition in the treatment of cardiovascular diseases continue. A phase 2a study (FLAVOR) was conducted to evaluate ...
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https://www.mdpi.com/1422-0067/23/9/4808/htm
Attempts to find applications of FLAP inhibition in the treatment of cardiovascular diseases continue. A phase 2a study (FLAVOR) was conducted to evaluate ...
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9
Role of the 5-Lipoxygenase–activating Protein (FLAP) in ...
https://rupress.org/jem/article/185/6/1065/25348/Role-of-the-5-Lipoxygenase-activating-Protein-FLAP
Leukotrienes are potent inflammatory mediators synthesized from arachidonic ... and FLAP (17), as well as studies of leukotriene inhibitors such as MK-886, ...
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https://rupress.org/jem/article/185/6/1065/25348/Role-of-the-5-Lipoxygenase-activating-Protein-FLAP
Leukotrienes are potent inflammatory mediators synthesized from arachidonic ... and FLAP (17), as well as studies of leukotriene inhibitors such as MK-886, ...
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10
Therapeutic role of dual inhibitors of 5-LOX and COX ...
https://ard.bmj.com/content/62/6/501
Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by blocking the formation of both prostaglandins and leucotrienes but do ...
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https://ard.bmj.com/content/62/6/501
Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by blocking the formation of both prostaglandins and leucotrienes but do ...
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11
A Single Amino Acid Difference between Mouse and Human 5 ...
https://www.jbc.org/article/S0021-9258(20)40913-5/fulltext
5-Lipoxygenase activating protein (FLAP) plays a critical role in the ... FLAP inhibitors for the treatment of inflammatory diseases.
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https://www.jbc.org/article/S0021-9258(20)40913-5/fulltext
5-Lipoxygenase activating protein (FLAP) plays a critical role in the ... FLAP inhibitors for the treatment of inflammatory diseases.
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12
Pharmacodynamics, pharmacokinetics and safety of GSK ...
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.2012.04386.x
5- lipoxygenase-activating protein (FLAP) inhibitors reduce both cysteinyl leukotrienes and the pro-inflammatory.
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https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.2012.04386.x
5- lipoxygenase-activating protein (FLAP) inhibitors reduce both cysteinyl leukotrienes and the pro-inflammatory.
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13
5-Lipoxygenase–Activating Protein | Circulation Research
https://www.ahajournals.org/doi/full/10.1161/01.RES.0000264498.60702.0d
FLAP protein expression in both the aorta and adipose tissue was detected in macrophages, but not in T cells. Four weeks of treatment with the FLAP inhibitor MK ...
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https://www.ahajournals.org/doi/full/10.1161/01.RES.0000264498.60702.0d
FLAP protein expression in both the aorta and adipose tissue was detected in macrophages, but not in T cells. Four weeks of treatment with the FLAP inhibitor MK ...
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14
What's all the FLAP about?: 5-lipoxygenase-activating protein ...
https://europepmc.org/article/med/18187210
Anti-leukotriene therapy has proven benefits in the treatment of respiratory disease, either through the inhibition of leukotriene synthesis or the ...
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https://europepmc.org/article/med/18187210
Anti-leukotriene therapy has proven benefits in the treatment of respiratory disease, either through the inhibition of leukotriene synthesis or the ...
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15
ajtr0119568.pdf - e-Century Publishing Corporation
https://e-century.us/files/ajtr/13/1/ajtr0119568.pdf
mPGES-1 inhibitors in treating inflammatory diseases ... tein (FLAP), and leukotriene C4 synthase. (LTC4S) [5].
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https://e-century.us/files/ajtr/13/1/ajtr0119568.pdf
mPGES-1 inhibitors in treating inflammatory diseases ... tein (FLAP), and leukotriene C4 synthase. (LTC4S) [5].
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16
Discovery of Novel 5‑Lipoxygenase-Activating Protein (FLAP ...
https://figshare.com/collections/Discovery_of_Novel_5_Lipoxygenase-Activating_Protein_FLAP_Inhibitors_by_Exploiting_a_Multistep_Virtual_Screening_Protocol/4868325
The aim of this study was to discover novel and chemically diverse FLAP inhibitors for treatment of inflammatory diseases requiring anti-LT ...
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https://figshare.com/collections/Discovery_of_Novel_5_Lipoxygenase-Activating_Protein_FLAP_Inhibitors_by_Exploiting_a_Multistep_Virtual_Screening_Protocol/4868325
The aim of this study was to discover novel and chemically diverse FLAP inhibitors for treatment of inflammatory diseases requiring anti-LT ...
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17
FLAP | Inhibitors - MedChemExpress
https://www.medchemexpress.com/Targets/FLAP.html
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and ...
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https://www.medchemexpress.com/Targets/FLAP.html
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and ...
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18
We value your privacy - SAGE Journals
https://journals.sagepub.com/doi/abs/10.1177/1087057115607815
Sampson, A. P. FLAP Inhibitors for the Treatment of Inflammatory Diseases. Curr. Opin. Investigational Drugs. 2009, 10 (11), 1163–1172.
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https://journals.sagepub.com/doi/abs/10.1177/1087057115607815
Sampson, A. P. FLAP Inhibitors for the Treatment of Inflammatory Diseases. Curr. Opin. Investigational Drugs. 2009, 10 (11), 1163–1172.
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19
5-Lipoxygenase Activating Protein (FLAP) Dependent ... - PLOS
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102622
We established that the FLAP inhibitor, MK591 attenuated inflammation induced by either whole LPS or the Lipid A fraction of LPS. Furthermore, ...
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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102622
We established that the FLAP inhibitor, MK591 attenuated inflammation induced by either whole LPS or the Lipid A fraction of LPS. Furthermore, ...
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20
Encapsulation of the Anti-inflammatory Dual FLAP/sEH ... - DOI
https://doi.org/10.1016/j.xphs.2021.10.030
Since diflapolin is a highly potent inhibitor of FLAP and sEH with IC50 values of 170 nm and 20 nm, respectively, the drug load was suggested to be sufficient ...
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https://doi.org/10.1016/j.xphs.2021.10.030
Since diflapolin is a highly potent inhibitor of FLAP and sEH with IC50 values of 170 nm and 20 nm, respectively, the drug load was suggested to be sufficient ...
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21
Amira Pharmaceuticals achieves milestones in FLAP inhibitor ...
https://pipelinereview.com/index.php/2008060320051/Small-Molecules/Amira-Pharmaceuticals-achieves-milestones-in-FLAP-inhibitor-program-with-GlaxoSmithKline.html
GSK exercises option for AM803, a FLAP inhibitor which recently ... to treat inflammatory disease linked to the eicosanoid pathway.
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https://pipelinereview.com/index.php/2008060320051/Small-Molecules/Amira-Pharmaceuticals-achieves-milestones-in-FLAP-inhibitor-program-with-GlaxoSmithKline.html
GSK exercises option for AM803, a FLAP inhibitor which recently ... to treat inflammatory disease linked to the eicosanoid pathway.
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22
Combined Machine Learning and GRID-Independent ...
https://www.frontiersin.org/articles/10.3389/fphar.2022.825741/full
Suppression of FLAP can inhibit LT production at the earliest level, providing relief to patients requiring anti-leukotriene therapy. Over the last 3 decades, ...
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https://www.frontiersin.org/articles/10.3389/fphar.2022.825741/full
Suppression of FLAP can inhibit LT production at the earliest level, providing relief to patients requiring anti-leukotriene therapy. Over the last 3 decades, ...
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23
Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 ...
https://d-nb.info/1214064558/34
inhibitors fail in intact cells. In view of the potential use of BRP-187 as drug for therapeutic treatment of chronic inflammatory diseases,.
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https://d-nb.info/1214064558/34
inhibitors fail in intact cells. In view of the potential use of BRP-187 as drug for therapeutic treatment of chronic inflammatory diseases,.
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24
Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 ...
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-020-00620-7
Dual inhibitors of the 5-lipoxygenase-activating protein (FLAP) and the microsomal prostaglandin E2 synthase-1 (mPGES-1) may exert better anti- ...
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https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-020-00620-7
Dual inhibitors of the 5-lipoxygenase-activating protein (FLAP) and the microsomal prostaglandin E2 synthase-1 (mPGES-1) may exert better anti- ...
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25
a Phase 2b Study of the 5-Lipoxygenase Activating Protein ...
https://www.kireports.org/article/S2468-0249(21)01403-0/pdf
Methods: FLAIR (FLAP Inhibition in Renal disease) is an ongoing phase 2b, ... chronic inflammatory diseases.23 Leukotrienes B4, C4,.
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https://www.kireports.org/article/S2468-0249(21)01403-0/pdf
Methods: FLAIR (FLAP Inhibition in Renal disease) is an ongoing phase 2b, ... chronic inflammatory diseases.23 Leukotrienes B4, C4,.
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26
Pharmacokinetics, Pharmacodynamics, and Tolerability of ...
https://link.springer.com/article/10.1007/s40261-021-01078-7
AZD5718, a 5-lipoxygenase-activating protein (FLAP) inhibitor, is in clinical development for treatment of coronary artery disease (CAD) and ...
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https://link.springer.com/article/10.1007/s40261-021-01078-7
AZD5718, a 5-lipoxygenase-activating protein (FLAP) inhibitor, is in clinical development for treatment of coronary artery disease (CAD) and ...
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27
US20110311613A1 - Topical formulations of flap inhibitors for ...
https://patents.google.com/patent/US20110311613A1/en
... of flap inhibitors for the treatment of dermatological conditions - Google Patents ... 200000000018 inflammatory disease Diseases 0.000 description 4 ...
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https://patents.google.com/patent/US20110311613A1/en
... of flap inhibitors for the treatment of dermatological conditions - Google Patents ... 200000000018 inflammatory disease Diseases 0.000 description 4 ...
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28
AZD6642|FLAP inhibitor|Datasheet - AdooQ® Bioscience
https://www.adooq.com/datasheet?A14400
AZD6642 is an inhibitor of 5-Lipoxygenase Activating Protein (FLAP) for the treatment of inflammatory diseases. Technical details ...
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https://www.adooq.com/datasheet?A14400
AZD6642 is an inhibitor of 5-Lipoxygenase Activating Protein (FLAP) for the treatment of inflammatory diseases. Technical details ...
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29
Leukotriene antagonists and synthesis inhibitors
https://www.jacionline.org/article/S0091-6749(96)70220-8/abstract
Although asthma was once regarded largely as a disease of airway smooth muscle, leading to treatment with oral and inhaled bronchodilators, investigations over ...
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https://www.jacionline.org/article/S0091-6749(96)70220-8/abstract
Although asthma was once regarded largely as a disease of airway smooth muscle, leading to treatment with oral and inhaled bronchodilators, investigations over ...
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30
Leukotrienes and sex: strange bedfellows? - JCI
https://www.jci.org/articles/view/95717
Although a number of inflammatory diseases, including scleroderma lung ... treatment of these diseases with leukotriene synthesis inhibitors ...
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https://www.jci.org/articles/view/95717
Although a number of inflammatory diseases, including scleroderma lung ... treatment of these diseases with leukotriene synthesis inhibitors ...
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31
Amira Pharmaceuticals and GlaxoSmithKline Enter Global ...
https://www.fiercebiotech.com/biotech/amira-pharmaceuticals-and-glaxosmithkline-enter-global-agreement-for-flap-inhibitor-program
A FLAP inhibitor with improved efficacy and equal or improved safety and tolerability to existing leukotriene receptor antagonists, in both asthma and rhinitis, ...
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https://www.fiercebiotech.com/biotech/amira-pharmaceuticals-and-glaxosmithkline-enter-global-agreement-for-flap-inhibitor-program
A FLAP inhibitor with improved efficacy and equal or improved safety and tolerability to existing leukotriene receptor antagonists, in both asthma and rhinitis, ...
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32
leukotriene receptors as therapeutic targets of inflammatory ...
https://academic.oup.com/intimm/article/31/9/607/5499361
Although BLT1 and CysLT signaling is implicated in diverse inflammatory diseases, CysLT1 antagonists are only used clinically for the treatment ...
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https://academic.oup.com/intimm/article/31/9/607/5499361
Although BLT1 and CysLT signaling is implicated in diverse inflammatory diseases, CysLT1 antagonists are only used clinically for the treatment ...
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33
5-Lipoxygenase and 5-Lipoxygenase Activating Protein (FLAP ...
https://www.atsjournals.org/doi/pdf/10.1164/ajrccm.157.1.9704003
Inflammatory infiltrates and endothelial cell proliferation have been appreciated in ... with interstitial lung disease (ILD), and normal control subjects.
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https://www.atsjournals.org/doi/pdf/10.1164/ajrccm.157.1.9704003
Inflammatory infiltrates and endothelial cell proliferation have been appreciated in ... with interstitial lung disease (ILD), and normal control subjects.
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34
5-Lipoxygenase–Deficient Mice Infected with Borrelia ...
https://www.jimmunol.org/content/186/5/3076.full.pdf
when targeting 5-LO as therapy for inflammatory diseases. The Journal of Immunology, ... a FLAP inhibitor, resulted in decreased anti-collagen IgG1 and.
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https://www.jimmunol.org/content/186/5/3076.full.pdf
when targeting 5-LO as therapy for inflammatory diseases. The Journal of Immunology, ... a FLAP inhibitor, resulted in decreased anti-collagen IgG1 and.
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35
AM103 Experimental Treatment for Respiratory Diseases
https://www.clinicaltrialsarena.com/projects/am103/
Currently available leukotriene receptor antagonists act via the type 1 leukotriene (CysLT1) receptor. By contrast, FLAP inhibitors target an ...
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https://www.clinicaltrialsarena.com/projects/am103/
Currently available leukotriene receptor antagonists act via the type 1 leukotriene (CysLT1) receptor. By contrast, FLAP inhibitors target an ...
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36
GSK to develop & market Amira's FLAP inhibitors
http://test.pharmabiz.com/news/gsk-to-develop-market-amira-s-flap-inhibitors-43429
FLAP inhibitors are also being investigated for use in other respiratory indications, including rhinitis, as well as having potential for the treatment of other ...
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http://test.pharmabiz.com/news/gsk-to-develop-market-amira-s-flap-inhibitors-43429
FLAP inhibitors are also being investigated for use in other respiratory indications, including rhinitis, as well as having potential for the treatment of other ...
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37
A Novel 5-Lipoxygenase-Activating Protein Inhibitor, AM679 ...
https://journals.asm.org/doi/10.1128/CVI.00220-09
These results suggest that FLAP inhibitors may be therapeutic for RSV-driven eye disease and possibly other inflammatory eye indications.
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https://journals.asm.org/doi/10.1128/CVI.00220-09
These results suggest that FLAP inhibitors may be therapeutic for RSV-driven eye disease and possibly other inflammatory eye indications.
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38
Leukotrienes: Inhibitors & Natural Ways to Block Them
https://selfhacked.com/blog/leukotrienes-inhibitors/
Moderate and severe asthma in people who are not being treated with oral ... However, whether they may help with inflammatory conditions ...
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https://selfhacked.com/blog/leukotrienes-inhibitors/
Moderate and severe asthma in people who are not being treated with oral ... However, whether they may help with inflammatory conditions ...
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39
Amira Pharmaceuticals Achieves Development Milestone ...
https://www.prnewswire.com/news-releases/amira-pharmaceuticals-achieves-development-milestone-related-to-flap-inhibitor-program-80902787.html
AM103 and AM803 bind to FLAP, inhibiting the synthesis of leukotrienes ... and early development of new drugs to treat inflammatory disease.
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https://www.prnewswire.com/news-releases/amira-pharmaceuticals-achieves-development-milestone-related-to-flap-inhibitor-program-80902787.html
AM103 and AM803 bind to FLAP, inhibiting the synthesis of leukotrienes ... and early development of new drugs to treat inflammatory disease.
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40
Shifting the biosynthesis of leukotrienes - Dove Medical Press
https://www.dovepress.com/shifting-the-biosynthesis-of-leukotrienes-toward-specialized-pro-resol-peer-reviewed-fulltext-article-JIR
Conclusion: BRP-201 acts as FLAP antagonist but also as 12/15-LOX activator switching formation of pro-inflammatory LTs toward ...
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https://www.dovepress.com/shifting-the-biosynthesis-of-leukotrienes-toward-specialized-pro-resol-peer-reviewed-fulltext-article-JIR
Conclusion: BRP-201 acts as FLAP antagonist but also as 12/15-LOX activator switching formation of pro-inflammatory LTs toward ...
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41
Effects of a 5-Lipoxygenase–Activating Protein Inhibitor on ...
https://jamanetwork.com/journals/jama/fullarticle/200867
Variants in the 5-lipoxygenase–activating protein (FLAP) gene are associated ... disease and/or taking chronic immunosuppressive therapy.
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https://jamanetwork.com/journals/jama/fullarticle/200867
Variants in the 5-lipoxygenase–activating protein (FLAP) gene are associated ... disease and/or taking chronic immunosuppressive therapy.
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42
Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP ...
https://aperta.ulakbim.gov.tr/record/10185
The aim of this study was to discover novel and chemically diverse FLAP inhibitors for treatment of inflammatory diseases requiring anti-LT ...
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https://aperta.ulakbim.gov.tr/record/10185
The aim of this study was to discover novel and chemically diverse FLAP inhibitors for treatment of inflammatory diseases requiring anti-LT ...
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43
Fiboflapon: Uses, Interactions, Mechanism of Action - DrugBank
https://go.drugbank.com/drugs/DB06346
Investigated for use/treatment in inflammatory disorders (unspecified). ... AM803 binds to FLAP, inhibiting the synthesis of leukotrienes ...
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https://go.drugbank.com/drugs/DB06346
Investigated for use/treatment in inflammatory disorders (unspecified). ... AM803 binds to FLAP, inhibiting the synthesis of leukotrienes ...
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44
Emerging anti-inflammatory strategies for COPD
https://erj.ersjournals.com/content/40/3/724
They are effective in the treatment of inflammatory diseases, ... The 5-lipoxygenase (LO) inhibitor, 5-LO activating protein (FLAP) inhibitor, ...
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https://erj.ersjournals.com/content/40/3/724
They are effective in the treatment of inflammatory diseases, ... The 5-lipoxygenase (LO) inhibitor, 5-LO activating protein (FLAP) inhibitor, ...
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45
5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS
https://data.epo.org/publication-server/rest/v1.0/publication-dates/20121003/patents/ep1933842nwb1/document.html
[0025] In another aspect the inflammatory conditions include, ... may comprise FLAP inhibitors disclosed herein for the treatment of asthma ...
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https://data.epo.org/publication-server/rest/v1.0/publication-dates/20121003/patents/ep1933842nwb1/document.html
[0025] In another aspect the inflammatory conditions include, ... may comprise FLAP inhibitors disclosed herein for the treatment of asthma ...
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46
miR-146a suppresses 5-lipoxygenase activating protein ...
https://www.oncotarget.com/article/25482/text/
5-LO and its activating protein (FLAP) work together in the first two conversion steps of ... protein inhibitors for inflammatory diseases.
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https://www.oncotarget.com/article/25482/text/
5-LO and its activating protein (FLAP) work together in the first two conversion steps of ... protein inhibitors for inflammatory diseases.
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47
Malin Lemurell - AstraZeneca
https://www.astrazeneca.com/our-company/our-people/malin-lemurell.html
I am particularly proud of the inventorship of a FLAP inhibitor which is ... Protein (FLAP) for the Treatment of Inflammatory Diseases.
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https://www.astrazeneca.com/our-company/our-people/malin-lemurell.html
I am particularly proud of the inventorship of a FLAP inhibitor which is ... Protein (FLAP) for the Treatment of Inflammatory Diseases.
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48
topical formulations of flap inhibitors for the treatment of ...
https://patents.justia.com/patent/20110311613
Topical administration of a 5-lipoxygenase activating protein (FLAP) inhibitor compound is used to treat dermal diseases, disorders or ...
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https://patents.justia.com/patent/20110311613
Topical administration of a 5-lipoxygenase activating protein (FLAP) inhibitor compound is used to treat dermal diseases, disorders or ...
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49
MemPro™ 5-Lipoxygenase–Activating Protein
https://www.creative-biostructure.com/MemPro%E2%84%A2-5-Lipoxygenase%E2%80%93Activating-Protein-104.htm
Leukotrienes have pathophysiological roles in respiratory diseases, allergic diseases and cardiovascular diseases (CVDs). It was recognized that FLAP inhibitors ...
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https://www.creative-biostructure.com/MemPro%E2%84%A2-5-Lipoxygenase%E2%80%93Activating-Protein-104.htm
Leukotrienes have pathophysiological roles in respiratory diseases, allergic diseases and cardiovascular diseases (CVDs). It was recognized that FLAP inhibitors ...
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50
Inhibition of 5-Lipoxygenase Product Synthesis by Natural ...
https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-2007-990242.pdf
ulonephritis, arthritis and chronic inflammatory bowel diseases ... tors of LT biosynthesis are so-called FLAP inhibitors (e.g., MK-.
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https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-2007-990242.pdf
ulonephritis, arthritis and chronic inflammatory bowel diseases ... tors of LT biosynthesis are so-called FLAP inhibitors (e.g., MK-.
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51
Antileukotriene agents in the management of asthma
https://www.uptodate.com/contents/antileukotriene-agents-in-the-management-of-asthma
Leukotrienes are powerful lipid mediators of inflammation generated ... as treatments for asthma, rhinitis, and other allergic diseases.
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https://www.uptodate.com/contents/antileukotriene-agents-in-the-management-of-asthma
Leukotrienes are powerful lipid mediators of inflammation generated ... as treatments for asthma, rhinitis, and other allergic diseases.
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52
Leukotrienes and kidney diseases
https://journals.lww.com/co-nephrolhypertens/fulltext/2018/01000/leukotrienes_and_kidney_diseases.8.aspx
LTC 4 inhibitors, commonly used as systemic asthma drugs, ... attenuated the treatment-associated increase in plasma LTB 4 and pro-inflammatory cytokines, ...
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https://journals.lww.com/co-nephrolhypertens/fulltext/2018/01000/leukotrienes_and_kidney_diseases.8.aspx
LTC 4 inhibitors, commonly used as systemic asthma drugs, ... attenuated the treatment-associated increase in plasma LTB 4 and pro-inflammatory cytokines, ...
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53
Ulcerative Colitis Medication - Medscape Reference
https://emedicine.medscape.com/article/183084-medication
Ulcerative colitis (UC) is one of the 2 major types of inflammatory bowel disease (IBD), along with Crohn disease. Unlike Crohn disease ...
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https://emedicine.medscape.com/article/183084-medication
Ulcerative colitis (UC) is one of the 2 major types of inflammatory bowel disease (IBD), along with Crohn disease. Unlike Crohn disease ...
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54
Drug discovery approaches targeting 5-lipoxygenase ...
https://avesis.gazi.edu.tr/yayin/f311c689-0ce7-43c5-a9a4-9f9627bdb445/drug-discovery-approaches-targeting-5-lipoxygenase-activating-protein-flap-for-inhibition-of-cellular-leukotriene-biosynthesis
The early development of FLAP inhibitors (i.e. MK-886, MK 591, BAY-X-1005) mostly concentrated on asthma cure, and resulted in promising readouts in preclinical ...
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https://avesis.gazi.edu.tr/yayin/f311c689-0ce7-43c5-a9a4-9f9627bdb445/drug-discovery-approaches-targeting-5-lipoxygenase-activating-protein-flap-for-inhibition-of-cellular-leukotriene-biosynthesis
The early development of FLAP inhibitors (i.e. MK-886, MK 591, BAY-X-1005) mostly concentrated on asthma cure, and resulted in promising readouts in preclinical ...
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55
Role of Leukotrienes on Protozoan and Helminth Infections
https://www.hindawi.com/journals/mi/2012/595694/
Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated ... and are involved in several inflammatory and infectious diseases [.
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https://www.hindawi.com/journals/mi/2012/595694/
Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated ... and are involved in several inflammatory and infectious diseases [.
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56
QSAR Study on 5-Lipoxygenase Activating Protein (FLAP ...
https://benthamscience.com/article/32121
The FLAP inhibitory activity of 2,2-bisaryl-bicycloheptane derivatives has been ... QSAR Study on 5-Lipoxygenase Activating Protein (FLAP) Inhibitors: The ...
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https://benthamscience.com/article/32121
The FLAP inhibitory activity of 2,2-bisaryl-bicycloheptane derivatives has been ... QSAR Study on 5-Lipoxygenase Activating Protein (FLAP) Inhibitors: The ...
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57
AZD5718 is an Orally Active Inhibitor of FLAP (5 ...
https://www.immune-system-research.com/cardiovascular/azd5718-is-an-orally-active-inhibitor-of-flap-5%E2%80%91lipoxygenase-activating-protein/2021-05-28/
FLAP is the target of leukotriene biosynthesis inhibitors. The 5-lipoxygenase pathway is responsible for the production of leukotrienes, lipid ...
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https://www.immune-system-research.com/cardiovascular/azd5718-is-an-orally-active-inhibitor-of-flap-5%E2%80%91lipoxygenase-activating-protein/2021-05-28/
FLAP is the target of leukotriene biosynthesis inhibitors. The 5-lipoxygenase pathway is responsible for the production of leukotrienes, lipid ...
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58
Pharmacodynamics and pharmacokinetics of AM103, a novel ...
https://www.pharmgkb.org/literature/7467978
Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP). Clinical pharmacology and therapeutics. 2010.
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https://www.pharmgkb.org/literature/7467978
Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP). Clinical pharmacology and therapeutics. 2010.
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59
FLAP inhibitor | BI 665915 | opnMe | Boehringer Ingelheim
https://opnme.com/molecules/flap-bi665915
5‑Lipoxygenase Activating Protein (FLAP) is an important protein in the Leukotriene pathway. BI 665915 demonstrates excellent FLAP binding potency with an ...
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https://opnme.com/molecules/flap-bi665915
5‑Lipoxygenase Activating Protein (FLAP) is an important protein in the Leukotriene pathway. BI 665915 demonstrates excellent FLAP binding potency with an ...
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60
Leukotrienes - biosynthesis and mechanisms of action
https://www.nps.org.au/australian-prescriber/articles/leukotrienes-biosynthesis-and-mechanisms-of-action
The leukotrienes are potent inflammatory mediators which may have a role in ... are also available that inhibit leukotriene synthesis by inhibition of FLAP.
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https://www.nps.org.au/australian-prescriber/articles/leukotrienes-biosynthesis-and-mechanisms-of-action
The leukotrienes are potent inflammatory mediators which may have a role in ... are also available that inhibit leukotriene synthesis by inhibition of FLAP.
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61
Drug discovery approaches targeting 5-lipoxygenase ... - X-MOL
https://www.x-mol.com/paper/308076
By blocking leukotriene production, FLAP inhibitors may behave as ... therapeutic use for chronic inflammatory diseases requiring anti-leukotriene therapy.
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https://www.x-mol.com/paper/308076
By blocking leukotriene production, FLAP inhibitors may behave as ... therapeutic use for chronic inflammatory diseases requiring anti-leukotriene therapy.
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62
5-Lipoxygenase-Activating Protein Inhibitors: Promising Drugs ...
https://neupsykey.com/5-lipoxygenase-activating-protein-inhibitors-promising-drugs-for-treating-acute-and-chronic-neuroinflammation-following-brain-injury/
FLAP inhibitors have also been proven safe and efficacious in asthma clinical trials but have not been brought to the market. Accumulating ...
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https://neupsykey.com/5-lipoxygenase-activating-protein-inhibitors-promising-drugs-for-treating-acute-and-chronic-neuroinflammation-following-brain-injury/
FLAP inhibitors have also been proven safe and efficacious in asthma clinical trials but have not been brought to the market. Accumulating ...
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63
FULLTEXT01.pdf - Uppsala University Publications
http://uu.diva-portal.org/smash/get/diva2:1700788/FULLTEXT01.pdf
disease [11–14]. In patients with myocardial infarction, a FLAP inhibitor (DG-031) reduced the level of biomarkers associated with an ...
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http://uu.diva-portal.org/smash/get/diva2:1700788/FULLTEXT01.pdf
disease [11–14]. In patients with myocardial infarction, a FLAP inhibitor (DG-031) reduced the level of biomarkers associated with an ...
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64
5-lipoxygenase-activating protein (flap) inhibitors - Google
https://www.google.com.gi/patents/EP1942896A2
Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, ...
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https://www.google.com.gi/patents/EP1942896A2
Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, ...
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65
A61P 29 - Non-central analgesic, antipyretic or antiinflammatory ...
http://www.google.com/patents/sitemap/en/Sitemap/A61/A61P/A61P_29_285.html
05/19/2011, WO2011058111A1 Aminopurine derivatives as kinase inhibitors ... as hif-inhibitors for the treatment of cancer and inflammatory diseases.
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http://www.google.com/patents/sitemap/en/Sitemap/A61/A61P/A61P_29_285.html
05/19/2011, WO2011058111A1 Aminopurine derivatives as kinase inhibitors ... as hif-inhibitors for the treatment of cancer and inflammatory diseases.
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66
AM-679 (FLAP inhibitor) - Wikipedia
https://en.wikipedia.org/wiki/AM-679_(FLAP_inhibitor)
AM-679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl ...
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https://en.wikipedia.org/wiki/AM-679_(FLAP_inhibitor)
AM-679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl ...
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67
Anti-leukotriene drugs in the therapy of inflammatory diseases
https://prospects.wum.edu.pl/index.php/pps/article/view/38
Regulation of their function allows to mute the inflammatory response, which is a desired effect in the treatment of inflammatory diseases.
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https://prospects.wum.edu.pl/index.php/pps/article/view/38
Regulation of their function allows to mute the inflammatory response, which is a desired effect in the treatment of inflammatory diseases.
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68
Definition of COX inhibitor - NCI Dictionary of Cancer Terms
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cox-inhibitor
A type of drug that is used to treat inflammation and pain, and is being studied in the prevention and treatment of cancer. COX inhibitors belong to the ...
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https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cox-inhibitor
A type of drug that is used to treat inflammation and pain, and is being studied in the prevention and treatment of cancer. COX inhibitors belong to the ...
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69
C07D 401 - Heterocyclic compounds containing two or more hetero ...
https://www.google.com/patents/sitemap/en/Sitemap/C07/C07D/C07D_401_433.html
09/19/2007, CN101039938A Diphenyl substituted alkanes as flap inhibitors ... treatment of various inflammatory diseases, autoimmune diseases, ...
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https://www.google.com/patents/sitemap/en/Sitemap/C07/C07D/C07D_401_433.html
09/19/2007, CN101039938A Diphenyl substituted alkanes as flap inhibitors ... treatment of various inflammatory diseases, autoimmune diseases, ...
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70
Medical Definition of FLAP - RxList
https://www.rxlist.com/flap/definition.htm
FLAP has been implicated in a number of inflammatory responses, including asthma, arthritis, psoriasis, heart attack and stroke. FLAP was the first gene ...
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https://www.rxlist.com/flap/definition.htm
FLAP has been implicated in a number of inflammatory responses, including asthma, arthritis, psoriasis, heart attack and stroke. FLAP was the first gene ...
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71
Treating Inflammatory Breast Cancer - American Cancer Society
https://www.cancer.org/cancer/breast-cancer/treatment/treatment-of-inflammatory-breast-cancer.html
This can include chemo, targeted therapy, hormone therapy (tamoxifen or an aromatase inhibitor) if the cancer cells have hormone receptors, the oral chemo drug ...
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https://www.cancer.org/cancer/breast-cancer/treatment/treatment-of-inflammatory-breast-cancer.html
This can include chemo, targeted therapy, hormone therapy (tamoxifen or an aromatase inhibitor) if the cancer cells have hormone receptors, the oral chemo drug ...
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72
Sarcoidosis of the ear, nose and throat: A review of the literature
https://medicaldialogues.in/ent/perspective/sarcoidosis-of-the-ear-nose-and-throat-a-review-of-the-literature-102763
Sarcoidosis is a chronic inflammatory disease of unknown aetiology, ... recognised ENT manifestations and discuss current treatment options.
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https://medicaldialogues.in/ent/perspective/sarcoidosis-of-the-ear-nose-and-throat-a-review-of-the-literature-102763
Sarcoidosis is a chronic inflammatory disease of unknown aetiology, ... recognised ENT manifestations and discuss current treatment options.
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73
A Novel Technique for Preparation of Recipient Site ... - Cureus
https://www.cureus.com/articles/120837-a-novel-technique-for-preparation-of-recipient-site-and-autologous-bone-grafting-in-autotransplantation-of-single-rooted-teeth-a-report-of-two-cases
After the elevation of the full-thickness flap, the initial and pilot ... After six months of autotransplantation, orthodontic treatment was ...
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https://www.cureus.com/articles/120837-a-novel-technique-for-preparation-of-recipient-site-and-autologous-bone-grafting-in-autotransplantation-of-single-rooted-teeth-a-report-of-two-cases
After the elevation of the full-thickness flap, the initial and pilot ... After six months of autotransplantation, orthodontic treatment was ...
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74
FLAP antagonist | FLAP inhibitor - Selleck Chemicals
https://www.selleckchem.com/flap.html
S8236, MK-886, MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα ...
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https://www.selleckchem.com/flap.html
S8236, MK-886, MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα ...
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75
OATD – Open Access Theses and Dissertations
https://oatd.org/
Recent Additions. See all of this week's new additions. Disruption of thiol proteostasis sensitizes cancer cells to proteasome inhibitor-mediated paraptosis. 서 ...
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https://oatd.org/
Recent Additions. See all of this week's new additions. Disruption of thiol proteostasis sensitizes cancer cells to proteasome inhibitor-mediated paraptosis. 서 ...
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76
Turmeric and 7 Other Anti-Inflammatory Spices for Arthritis
https://www.healthline.com/health/osteoarthritis/turmeric-and-anti-inflammatory-herbs
Certain herbs and spices are known to have anti-inflammatory properties. ... a medicine for centuries to treat wounds, infections, colds, and liver disease.
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https://www.healthline.com/health/osteoarthritis/turmeric-and-anti-inflammatory-herbs
Certain herbs and spices are known to have anti-inflammatory properties. ... a medicine for centuries to treat wounds, infections, colds, and liver disease.
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77
FLAP - DC Chemicals
https://www.dcchemicals.com/products/flap.html
Home > Inhibitors & Agonists > Immunology/Inflammation > FLAP. Cat. No. Product name, CAS No. DC9448 · MK591. MK591(Quiflapon sodium) is a selective and ...
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https://www.dcchemicals.com/products/flap.html
Home > Inhibitors & Agonists > Immunology/Inflammation > FLAP. Cat. No. Product name, CAS No. DC9448 · MK591. MK591(Quiflapon sodium) is a selective and ...
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78
Inflammatory Immune Disease: Molecular Mechanisms, ...
https://books.google.com/books?id=X_l4EAAAQBAJ&pg=PA107&lpg=PA107&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=kq9jdBd47I&sig=ACfU3U06Y5OBaU06t5VKfbenKezn8foAkQ&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQipAhAD
However, immunosuppressive treatment of DM/PM cannot sufficiently suppress the LTB4 pathway, and FLAP inhibitors might be an ideal choice; this possibility ...
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https://books.google.com/books?id=X_l4EAAAQBAJ&pg=PA107&lpg=PA107&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=kq9jdBd47I&sig=ACfU3U06Y5OBaU06t5VKfbenKezn8foAkQ&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQipAhAD
However, immunosuppressive treatment of DM/PM cannot sufficiently suppress the LTB4 pathway, and FLAP inhibitors might be an ideal choice; this possibility ...
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79
The Eicosanoids - Page 138 - Google Books Result
https://books.google.com/books?id=Bl_R0baVKhEC&pg=PA138&lpg=PA138&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=OL562FsaS2&sig=ACfU3U0YT4LZ6XUQZjANaQu7x004SZoQew&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQinAhAD
The recruited neutrophils by LTB4 at the inflammatory site render the neutrophils ... approaches for the treatment of inflammatory diseases, such as asthma.
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https://books.google.com/books?id=Bl_R0baVKhEC&pg=PA138&lpg=PA138&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=OL562FsaS2&sig=ACfU3U0YT4LZ6XUQZjANaQu7x004SZoQew&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQinAhAD
The recruited neutrophils by LTB4 at the inflammatory site render the neutrophils ... approaches for the treatment of inflammatory diseases, such as asthma.
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80
Nanomedicine for Inflammatory Diseases
https://books.google.com/books?id=aDwPEAAAQBAJ&pg=PA284&lpg=PA284&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=KuI8TQ3WBQ&sig=ACfU3U39x7cs3-C0D9qrjrc5eEGEO1mwHQ&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQioAhAD
Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist ... Effect of FLAP antagonist MK-0591 on leukotriene sense therapeutic ...
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https://books.google.com/books?id=aDwPEAAAQBAJ&pg=PA284&lpg=PA284&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=KuI8TQ3WBQ&sig=ACfU3U39x7cs3-C0D9qrjrc5eEGEO1mwHQ&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQioAhAD
Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist ... Effect of FLAP antagonist MK-0591 on leukotriene sense therapeutic ...
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81
Side-Effects of Anti-Inflammatory Drugs 3
https://books.google.com/books?id=JT36CAAAQBAJ&pg=PA371&lpg=PA371&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=v_iwrgaFM6&sig=ACfU3U1R_V4xir-vs4Nj85wmk3bN-Uixgw&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQihAhAD
... 82–3, 87 joint, see arthritis inflammatory bowel disease, 81 experimental ... 277,285 L-670,596, 279 L-689,083, 281, 282 lactation, gold therapy and, ...
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https://books.google.com/books?id=JT36CAAAQBAJ&pg=PA371&lpg=PA371&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=v_iwrgaFM6&sig=ACfU3U1R_V4xir-vs4Nj85wmk3bN-Uixgw&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQihAhAD
... 82–3, 87 joint, see arthritis inflammatory bowel disease, 81 experimental ... 277,285 L-670,596, 279 L-689,083, 281, 282 lactation, gold therapy and, ...
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82
Journal of the American Medical Association
https://books.google.com/books?id=y0QKAQAAMAAJ&pg=RA1-PA1736&lpg=RA1-PA1736&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=g32LGJem_Z&sig=ACfU3U3ZY8FCTxHPoXonojSYCa96vXVYiA&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQiiAhAD
( 108 ) 1388 of , ( 57 ) 1391 ( 47 ) 1518 Headaches , etiology and treat- ... 984 340 tral disorder of , ( 120 ) 932 and arterial diseases , treat .
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https://books.google.com/books?id=y0QKAQAAMAAJ&pg=RA1-PA1736&lpg=RA1-PA1736&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=g32LGJem_Z&sig=ACfU3U3ZY8FCTxHPoXonojSYCa96vXVYiA&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQiiAhAD
( 108 ) 1388 of , ( 57 ) 1391 ( 47 ) 1518 Headaches , etiology and treat- ... 984 340 tral disorder of , ( 120 ) 932 and arterial diseases , treat .
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83
The Lancet - Volume 1 - Page xxvii - Google Books Result
https://books.google.com/books?id=sQNBAQAAMAAJ&pg=PR27&lpg=PR27&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=4J14Z5Rgb-&sig=ACfU3U3GWae3f-FzyeOBSCTGcBTwxLkExg&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQimAhAD
585 diseases of , 1222 ; European , in the plague Asylum dysentery ... 40 ; treatment of sterility in women , 511 -- Dis- nystagmus ; Small flap sclerotomy ...
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https://books.google.com/books?id=sQNBAQAAMAAJ&pg=PR27&lpg=PR27&dq=flap+inhibitors+treatment+inflammatory+diseases&source=bl&ots=4J14Z5Rgb-&sig=ACfU3U3GWae3f-FzyeOBSCTGcBTwxLkExg&hl=en&sa=X&ved=2ahUKEwih0IHSpcv7AhWApIkEHfw0B0sQ6AF6BQimAhAD
585 diseases of , 1222 ; European , in the plague Asylum dysentery ... 40 ; treatment of sterility in women , 511 -- Dis- nystagmus ; Small flap sclerotomy ...
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