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Google Keyword Rankings for : nitroglycerin treatment fissures
1
Nitroglycerin (Rectal Route) Description and Brand Names
https://www.mayoclinic.org/drugs-supplements/nitroglycerin-rectal-route/description/drg-20075252
Nitroglycerin rectal ointment is used to relieve moderate to severe pain caused by chronic anal fissures. An anal fissure is a tear in the skin around the ...
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https://www.mayoclinic.org/drugs-supplements/nitroglycerin-rectal-route/description/drg-20075252
Nitroglycerin rectal ointment is used to relieve moderate to severe pain caused by chronic anal fissures. An anal fissure is a tear in the skin around the ...
→ Check Latest Keyword Rankings ←
2
Nitroglycerin ointment for anal fissures: effective treatment or ...
https://pubmed.ncbi.nlm.nih.gov/10223761/
Topical nitroglycerin was only effective in approximately one-half of patients with an anal fissure. There was a very high incidence of adverse reactions.
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https://pubmed.ncbi.nlm.nih.gov/10223761/
Topical nitroglycerin was only effective in approximately one-half of patients with an anal fissure. There was a very high incidence of adverse reactions.
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3
Anal Fissures: Nitroglycerin Ointment - Topic Overview
https://wa.kaiserpermanente.org/kbase/topic.jhtml?docId=uf4775
Nitroglycerin is usually the first medicine used to treat a chronic anal fissure. Many studies have shown that it works better than conservative treatment ...
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https://wa.kaiserpermanente.org/kbase/topic.jhtml?docId=uf4775
Nitroglycerin is usually the first medicine used to treat a chronic anal fissure. Many studies have shown that it works better than conservative treatment ...
→ Check Latest Keyword Rankings ←
4
Nitroglycerin Ointment - Uses, Side Effects, and More - WebMD
https://www.webmd.com/drugs/2/drug-159295/nitroglycerin-rectal/details
Nitroglycerin ointment is used to treat moderate to severe pain caused by long-term tears in the lining of the anus (anal fissures).
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https://www.webmd.com/drugs/2/drug-159295/nitroglycerin-rectal/details
Nitroglycerin ointment is used to treat moderate to severe pain caused by long-term tears in the lining of the anus (anal fissures).
→ Check Latest Keyword Rankings ←
5
Topical Nitroglycerin Therapy for Anal Fissures and Ulcers
https://www.nejm.org/doi/full/10.1056/nejm199510263331718
Nitroglycerin, which is locally metabolized to nitric oxide, lowers the mean resting pressure of the anal sphincter when applied topically to ...
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https://www.nejm.org/doi/full/10.1056/nejm199510263331718
Nitroglycerin, which is locally metabolized to nitric oxide, lowers the mean resting pressure of the anal sphincter when applied topically to ...
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6
Nitroglycerin Topical: MedlinePlus Drug Information
https://medlineplus.gov/druginfo/meds/a682346.html
Nitroglycerin ointment (Rectiv) is used in adults to treat pain from anal fissures (a split or tear in the tissue near the rectal area).
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https://medlineplus.gov/druginfo/meds/a682346.html
Nitroglycerin ointment (Rectiv) is used in adults to treat pain from anal fissures (a split or tear in the tissue near the rectal area).
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7
About RECTIV
https://www.rectiv.com/en/about_rectiv
RECTIV, a nitroglycerin ointment, is the only FDA-approved medicine for the treatment of moderate to severe pain from chronic anal fissure.
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https://www.rectiv.com/en/about_rectiv
RECTIV, a nitroglycerin ointment, is the only FDA-approved medicine for the treatment of moderate to severe pain from chronic anal fissure.
→ Check Latest Keyword Rankings ←
8
Nitroglycerin Ointment For Fissure Treatment in India
https://www.pristyncare.com/blog/nitroglycerin-ointment-for-fissure-treatment-pc0113/
Nitroglycerin ointment treats moderate to severe pain caused in the lining of the anus, mostly anal fissures. The ointment works by relaxing ...
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https://www.pristyncare.com/blog/nitroglycerin-ointment-for-fissure-treatment-pc0113/
Nitroglycerin ointment treats moderate to severe pain caused in the lining of the anus, mostly anal fissures. The ointment works by relaxing ...
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9
Patient education: Anal fissure (Beyond the Basics) - UpToDate
https://www.uptodate.com/contents/anal-fissure-beyond-the-basics
The dose of nitroglycerin is usually a small, pea-sized dot of 0.2 to 0.4% ointment applied around the anal opening two times daily. The lower ...
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https://www.uptodate.com/contents/anal-fissure-beyond-the-basics
The dose of nitroglycerin is usually a small, pea-sized dot of 0.2 to 0.4% ointment applied around the anal opening two times daily. The lower ...
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10
Rectiv (nitroglycerin): Basics, Side Effects & Reviews - GoodRx
https://www.goodrx.com/rectiv/what-is
Rectiv (nitroglycerin) is an ointment that works well to treat anal fissure pain and improve healing, but it commonly causes headaches.
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https://www.goodrx.com/rectiv/what-is
Rectiv (nitroglycerin) is an ointment that works well to treat anal fissure pain and improve healing, but it commonly causes headaches.
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11
Internal sphincterotomy versus topical nitroglycerin ointment ...
https://www.sciencedirect.com/science/article/pii/S1015958413000614
In this study, using a 0.5 mL dose of 0.2% nitroglycerin, we have observed healing of the fissure in 50% of patients after 6 weeks, which is comparable with the ...
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https://www.sciencedirect.com/science/article/pii/S1015958413000614
In this study, using a 0.5 mL dose of 0.2% nitroglycerin, we have observed healing of the fissure in 50% of patients after 6 weeks, which is comparable with the ...
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12
Nitroglycerin in the Treatment of Anal Fissure | 1997-03-15
https://www.reliasmedia.com/articles/37146-nitroglycerin-in-the-treatment-of-anal-fissure
Nitroglycerin ointment seems to be a viable treatment alternative to surgery of anal fissures. COMMENT BY LEN SCARPINATO, DO. The efficacy of nitroglycerin in ...
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https://www.reliasmedia.com/articles/37146-nitroglycerin-in-the-treatment-of-anal-fissure
Nitroglycerin ointment seems to be a viable treatment alternative to surgery of anal fissures. COMMENT BY LEN SCARPINATO, DO. The efficacy of nitroglycerin in ...
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13
Nitroglycerin 0.4% ointment vs placebo in the treatment of ...
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-13-106
The first approved prescription product to treat chronic anal fissure (CAF) pain in the United States is nitroglycerin (NTG) 0.4% ointment ...
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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-13-106
The first approved prescription product to treat chronic anal fissure (CAF) pain in the United States is nitroglycerin (NTG) 0.4% ointment ...
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14
Nitroglycerin 0.2% Ointment - Treatment to Relieve Anal ...
https://www.parkcompounding.com/compounds/gastroenterology/nitroglycerin-ointment/
This compounded ointment is used to treat anal fissures. Nitroglycerin is in the nitrate family and works to dilate blood vessels, ...
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https://www.parkcompounding.com/compounds/gastroenterology/nitroglycerin-ointment/
This compounded ointment is used to treat anal fissures. Nitroglycerin is in the nitrate family and works to dilate blood vessels, ...
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15
Long-term results of topical nitroglycerin in the treatment of ...
https://link.springer.com/article/10.1007/s101510100016
Healing rate with placebo for chronic fissures was only anecdotical (1 out of 16 patients). Headache as side effects occurred in 17 cases (77%).
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https://link.springer.com/article/10.1007/s101510100016
Healing rate with placebo for chronic fissures was only anecdotical (1 out of 16 patients). Headache as side effects occurred in 17 cases (77%).
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16
Rectiv (nitroglycerin rectal) dosing, indications, interactions ...
https://reference.medscape.com/drug/rectiv-nitroglycerin-rectal-999667
ointment, intra-anal. 0.4% (4mg nitroglycerin/1g of ointment) ; Chronic Rectal Fissure Pain. Indicated for treatment of moderate-to-severe pain associated with ...
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https://reference.medscape.com/drug/rectiv-nitroglycerin-rectal-999667
ointment, intra-anal. 0.4% (4mg nitroglycerin/1g of ointment) ; Chronic Rectal Fissure Pain. Indicated for treatment of moderate-to-severe pain associated with ...
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17
Treatment of anal fissures with topical nitroglycerin
https://www.tandfonline.com/doi/pdf/10.1517/14656566.2.1.41
topical nitroglycerin for the treatment of anal fissures, there remains no ... symptomatic anal fissure, conservative treatment using stool softeners,.
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https://www.tandfonline.com/doi/pdf/10.1517/14656566.2.1.41
topical nitroglycerin for the treatment of anal fissures, there remains no ... symptomatic anal fissure, conservative treatment using stool softeners,.
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18
Nitroglycerin rectal Uses, Side Effects & Warnings
https://www.drugs.com/mtm/nitroglycerin-rectal.html
Nitroglycerin rectal is used to treat moderate to severe pain caused by chronic anal fissures (tears in the skin lining your rectum).
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https://www.drugs.com/mtm/nitroglycerin-rectal.html
Nitroglycerin rectal is used to treat moderate to severe pain caused by chronic anal fissures (tears in the skin lining your rectum).
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19
A dose finding study with 0.1%, 0.2%, and 0.4% glyceryl ...
https://gut.bmj.com/content/52/2/264
In conclusion, topical GTN remains the most widely used non-surgical treatment for chronic anal fissure. It is generally regarded as being effective in the ...
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https://gut.bmj.com/content/52/2/264
In conclusion, topical GTN remains the most widely used non-surgical treatment for chronic anal fissure. It is generally regarded as being effective in the ...
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20
Patient Drug Education for Nitroglycerin Ointment
https://physicians.crhsystem.com/wp-content/uploads/NTG-Education_r2-1.doc
Nitroglycerin ointment (NTG) is often used to help heal anal fissures. ... It is important to continue the treatment for the entire time period – up to 3 ...
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https://physicians.crhsystem.com/wp-content/uploads/NTG-Education_r2-1.doc
Nitroglycerin ointment (NTG) is often used to help heal anal fissures. ... It is important to continue the treatment for the entire time period – up to 3 ...
→ Check Latest Keyword Rankings ←
21
Anal Fissures: A Real Pain - Pharmacy Times
https://www.pharmacytimes.com/view/anal-fissures-a-real-pain
Applied anally, nitroglycerin ointment— in strengths lower than those used for angina—twice daily for up to 3 weeks dilates blood vessels and ...
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https://www.pharmacytimes.com/view/anal-fissures-a-real-pain
Applied anally, nitroglycerin ointment— in strengths lower than those used for angina—twice daily for up to 3 weeks dilates blood vessels and ...
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22
Local nitroglycerin for treatment of anal fissures
https://www.semanticscholar.org/paper/Local-nitroglycerin-for-treatment-of-anal-fissures%3A-Bacher-Mischinger/2538034e6a1d7e9803154123d58fb6dbd4b89be5
Topical application of nitroglycerine represents a new, easily handled, and effective alternative in the treatment of anal fissures, ...
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https://www.semanticscholar.org/paper/Local-nitroglycerin-for-treatment-of-anal-fissures%3A-Bacher-Mischinger/2538034e6a1d7e9803154123d58fb6dbd4b89be5
Topical application of nitroglycerine represents a new, easily handled, and effective alternative in the treatment of anal fissures, ...
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23
Anal Fissure - Symptoms, Causes and Treatment
https://www.harborcompounding.com/recent-advances-in-the-treatment-of-anal-fissures
When ointments containing nitroglycerin are applied to the anal canal, the nitroglycerin diffuses across the anoderm and relaxes the internal sphincter and ...
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https://www.harborcompounding.com/recent-advances-in-the-treatment-of-anal-fissures
When ointments containing nitroglycerin are applied to the anal canal, the nitroglycerin diffuses across the anoderm and relaxes the internal sphincter and ...
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24
A comparison of injections of botulinum toxin ... - Read by QxMD
https://read.qxmd.com/read/10395629/a-comparison-of-injections-of-botulinum-toxin-and-topical-nitroglycerin-ointment-for-the-treatment-of-chronic-anal-fissure
CONCLUSIONS: Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal ...
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https://read.qxmd.com/read/10395629/a-comparison-of-injections-of-botulinum-toxin-and-topical-nitroglycerin-ointment-for-the-treatment-of-chronic-anal-fissure
CONCLUSIONS: Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal ...
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25
A Study to Determine the Effect of Nitroglycerin Ointment 0.4 ...
https://clinicaltrials.gov/ct2/show/NCT00522041
A Study to Determine the Effect of Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With Chronic Anal Fissures ...
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https://clinicaltrials.gov/ct2/show/NCT00522041
A Study to Determine the Effect of Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With Chronic Anal Fissures ...
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26
Patient Drug Education for Nitroglycerin Ointment
https://digestivehealth.net/images/nitroglycerin_patient_education.pdf
Nitroglycerin ointment (NTG) is used to help heal anal fissures. ... It is important to continue the treatment for the entire time period.
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https://digestivehealth.net/images/nitroglycerin_patient_education.pdf
Nitroglycerin ointment (NTG) is used to help heal anal fissures. ... It is important to continue the treatment for the entire time period.
→ Check Latest Keyword Rankings ←
27
Nitroglycerin Ointment - Topical Treatment for Anal Fissures
https://www.nationalpharmacyrx.com/gastroenterology/nitroglycerin-ointment/
Cream for treating anal fissures. ... Description: Nitroglycerin dilates blood vessels to help improve anal fissures. The medication works to relax smooth muscle ...
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https://www.nationalpharmacyrx.com/gastroenterology/nitroglycerin-ointment/
Cream for treating anal fissures. ... Description: Nitroglycerin dilates blood vessels to help improve anal fissures. The medication works to relax smooth muscle ...
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28
0.4% nitroglycerin ointment: in the treatment of chronic anal ...
https://go.gale.com/ps/i.do?id=GALE%7CA200559893&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=00126667&p=HRCA&sw=w
* 0.4% Nitroglycerin ointment is an intra-anal formulation of nitroglycerin (glyceryl trinitrate) indicated for the treatment of chronic anal fissure pain. * ...
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https://go.gale.com/ps/i.do?id=GALE%7CA200559893&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=00126667&p=HRCA&sw=w
* 0.4% Nitroglycerin ointment is an intra-anal formulation of nitroglycerin (glyceryl trinitrate) indicated for the treatment of chronic anal fissure pain. * ...
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29
Botox vs. Nitroglycerin for Anal Fissures - NEJM Journal Watch
https://www.jwatch.org/jg200612010000005/2006/12/01/botox-vs-nitroglycerin-anal-fissures
Either nitroglycerin ointment or injected botulinum toxin A (Botox) is used to relieve symptoms of and to heal chronic anal fissures.
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https://www.jwatch.org/jg200612010000005/2006/12/01/botox-vs-nitroglycerin-anal-fissures
Either nitroglycerin ointment or injected botulinum toxin A (Botox) is used to relieve symptoms of and to heal chronic anal fissures.
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30
Anal Fissure Treatments & Medications - SingleCare
https://www.singlecare.com/conditions/anal-fissure-treatment-and-medications
Chronic anal fissures will require medications to relax the anal sphincter muscles, such as topical nitroglycerin or blood pressure ...
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https://www.singlecare.com/conditions/anal-fissure-treatment-and-medications
Chronic anal fissures will require medications to relax the anal sphincter muscles, such as topical nitroglycerin or blood pressure ...
→ Check Latest Keyword Rankings ←
31
Nitroglycerin topical ointment for fissures - FAST shipping
https://earlychildhoodny.org/nitroglycerin-fissures-2167545
Nitroglycerin is used to treat chest pain (angina), heart attack (myocardial infarction) and prevention of migraine headaches with aura (visual ...
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https://earlychildhoodny.org/nitroglycerin-fissures-2167545
Nitroglycerin is used to treat chest pain (angina), heart attack (myocardial infarction) and prevention of migraine headaches with aura (visual ...
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32
Rectiv (Nitroglycerin Rectal): Uses, Dosage, Side ... - RxList
https://www.rxlist.com/rectiv-drug.htm
Rectiv is a prescription medicine used to treat the symptoms of Chronic Rectal Fissure Pain. Rectiv may be used alone or with other medications. Rectiv belongs ...
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https://www.rxlist.com/rectiv-drug.htm
Rectiv is a prescription medicine used to treat the symptoms of Chronic Rectal Fissure Pain. Rectiv may be used alone or with other medications. Rectiv belongs ...
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33
Pearls of Wisdom: Anal Fissures - Consultant360
https://www.consultant360.com/exclusives/pearls-wisdom-anal-fissures
Agents that reduce anal tone, such as nitroglycerin ointment 0.2%, may offer rescue treatment for otherwise refractory anal fissure. Reference: 1. Lund JN, ...
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https://www.consultant360.com/exclusives/pearls-wisdom-anal-fissures
Agents that reduce anal tone, such as nitroglycerin ointment 0.2%, may offer rescue treatment for otherwise refractory anal fissure. Reference: 1. Lund JN, ...
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34
Treatment of anal fissures with topical nitroglycerin
https://www.researchgate.net/publication/11999708_Treatment_of_anal_fissures_with_topical_nitroglycerin
... Topical nitroglycerin is being used in the treatment of anal fissures and is recommended as an alternative treatment option to surgery. [20] ...
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https://www.researchgate.net/publication/11999708_Treatment_of_anal_fissures_with_topical_nitroglycerin
... Topical nitroglycerin is being used in the treatment of anal fissures and is recommended as an alternative treatment option to surgery. [20] ...
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35
Nitroglycerin: Uses, dosage, side effects, risks, and interactions
https://www.medicalnewstoday.com/articles/325187
Nitroglycerin helps open up the blood vessels and allows blood to flow. People can also use nitroglycerin to treat anal fissures. This article provides an ...
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https://www.medicalnewstoday.com/articles/325187
Nitroglycerin helps open up the blood vessels and allows blood to flow. People can also use nitroglycerin to treat anal fissures. This article provides an ...
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36
Glyceryl trinitrate rectal ointment for anal fissure - Patient.info
https://patient.info/medicine/glyceryl-trinitrate-rectal-ointment-rectogesic
Glyceryl trinitrate (GTN) rectal ointment works by relaxing the muscle just around your anus and reducing anal fissure(s)
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https://patient.info/medicine/glyceryl-trinitrate-rectal-ointment-rectogesic
Glyceryl trinitrate (GTN) rectal ointment works by relaxing the muscle just around your anus and reducing anal fissure(s)
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37
A study to determine the nitroglycerin ointment dose and ...
https://researchexperts.utmb.edu/en/publications/a-study-to-determine-the-nitroglycerin-ointment-dose-and-dosing-i
RESULTS: There were no significant differences in fissure healing among any of the treatment groups; all groups, including placebo had a healing ...
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https://researchexperts.utmb.edu/en/publications/a-study-to-determine-the-nitroglycerin-ointment-dose-and-dosing-i
RESULTS: There were no significant differences in fissure healing among any of the treatment groups; all groups, including placebo had a healing ...
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38
Nitro-Bid (nitroglycerin) dose, indications, adverse ... - PDR.Net
https://www.pdr.net/drug-summary/Nitro-Bid-nitroglycerin-778
For the treatment of moderate to severe pain associated with chronic anal fissures. Intra-Anal dosage (0.4% rectal ointment).
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https://www.pdr.net/drug-summary/Nitro-Bid-nitroglycerin-778
For the treatment of moderate to severe pain associated with chronic anal fissures. Intra-Anal dosage (0.4% rectal ointment).
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39
US20020049188A1 - Nitroglycerin ointment for treatment of ...
https://patents.google.com/patent/US20020049188A1/en
The present invention provides methods for reducing pain associated with chronic anal fissures with reduced side effects, comprising: contacting an anal ...
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https://patents.google.com/patent/US20020049188A1/en
The present invention provides methods for reducing pain associated with chronic anal fissures with reduced side effects, comprising: contacting an anal ...
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40
Randomized clinical trial comparing botulinum toxin injections ...
https://academic.oup.com/bjs/article/94/2/162/6142586
Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, ...
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https://academic.oup.com/bjs/article/94/2/162/6142586
Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, ...
→ Check Latest Keyword Rankings ←
41
Treatment of Chronic Anal Fissure with Topical Nitroglycerin.
https://coloproctol.org/m/journal/view.php?number=529
Twenty nine patients (19 women, mean age 36 years) with chronic anal fissure were treated with 0.2% nitroglycerin ointment. Pain score was quantitated with ...
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https://coloproctol.org/m/journal/view.php?number=529
Twenty nine patients (19 women, mean age 36 years) with chronic anal fissure were treated with 0.2% nitroglycerin ointment. Pain score was quantitated with ...
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42
Non Surgical Treatment of Chronic Anal Fissure: Nitroglycerin ...
http://www.aamj.eg.net/journals/pdf/898.pdf
nitroglycerin and anal dilatation and B: 30 patients treated by local Botulinum ... increasing popularity for the treatment of anal fissures. With so many.
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http://www.aamj.eg.net/journals/pdf/898.pdf
nitroglycerin and anal dilatation and B: 30 patients treated by local Botulinum ... increasing popularity for the treatment of anal fissures. With so many.
→ Check Latest Keyword Rankings ←
43
Topical nitroglycerin in the management of anal fissure
https://search.proquest.com/openview/d0da0eff765f5f6e1faea5dc114ece0f/1?pq-origsite=gscholar&cbl=49079
Topical nitroglycerin (NTG), a nitric oxide donor compound, has been shown to cause relaxation of the anal sphincter and may have treatment efficacy in the ...
→ Check Latest Keyword Rankings ←
https://search.proquest.com/openview/d0da0eff765f5f6e1faea5dc114ece0f/1?pq-origsite=gscholar&cbl=49079
Topical nitroglycerin (NTG), a nitric oxide donor compound, has been shown to cause relaxation of the anal sphincter and may have treatment efficacy in the ...
→ Check Latest Keyword Rankings ←
44
Nitroglycerine: A Paradigm in Treatment of Chronic Anal Fissure
https://medwinpublishers.com/MJCCS/MJCCS16000102.pdf
blockers offer a suitable alternative for fissure treatment, ... nitroglycerin for treatment of anal fissures: an.
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https://medwinpublishers.com/MJCCS/MJCCS16000102.pdf
blockers offer a suitable alternative for fissure treatment, ... nitroglycerin for treatment of anal fissures: an.
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45
RECTIV (nitroglycerin) Ointment 0.4%, for intra-anal use
https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021359s000lbl.pdf
... the treatment of moderate to severe pain associated with chronic anal fissure (1). ... consequence of nitroglycerin treatment can result in hypotension.
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https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021359s000lbl.pdf
... the treatment of moderate to severe pain associated with chronic anal fissure (1). ... consequence of nitroglycerin treatment can result in hypotension.
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46
Topical Nifedipine Plus Lidocaine Gel Effective for Anal Fissures
https://www.aafp.org/pubs/afp/issues/2003/0415/p1781.html
Synopsis: Treatment of chronic anal fissures includes stool softeners, topical anesthetics, and nitroglycerin ointment.
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https://www.aafp.org/pubs/afp/issues/2003/0415/p1781.html
Synopsis: Treatment of chronic anal fissures includes stool softeners, topical anesthetics, and nitroglycerin ointment.
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47
Managing anal fissures - Page 2 of 2 - Clinical Advisor
https://www.clinicaladvisor.com/home/features/managing-anal-fissures/2/
Patient-applied treatment is with a small amount of 0.2% nitroglycerin ointment around the anal opening two to three times per day and, if ...
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https://www.clinicaladvisor.com/home/features/managing-anal-fissures/2/
Patient-applied treatment is with a small amount of 0.2% nitroglycerin ointment around the anal opening two to three times per day and, if ...
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48
A study to determine the nitroglycerin ointment dose ... - VIVO
https://vivo.weill.cornell.edu/display/pubid12352236
RESULTS: There were no significant differences in fissure healing among any of the treatment groups; all groups, including placebo had a healing ...
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https://vivo.weill.cornell.edu/display/pubid12352236
RESULTS: There were no significant differences in fissure healing among any of the treatment groups; all groups, including placebo had a healing ...
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49
Controlled Dose Delivery in Topical Treatment of Anal Fissure
https://doserite.info/wp-content/uploads/2017/09/Salgado-Gervasio-Article-June-2006.pdf
with chronic anal fissure and no previous treatment were randomly allocated to receive 0.75 ml of 0.3 percent nitroglycerin ointment (2.25 mg nitroglycerin) ...
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https://doserite.info/wp-content/uploads/2017/09/Salgado-Gervasio-Article-June-2006.pdf
with chronic anal fissure and no previous treatment were randomly allocated to receive 0.75 ml of 0.3 percent nitroglycerin ointment (2.25 mg nitroglycerin) ...
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50
0.4% nitroglycerin ointment in the treatment of ... - EurekaMag
https://eurekamag.com/research/048/008/048008326.php
Lund, J.N., 2006: 0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain : a viewpoint by Jonathan N. Lund.
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https://eurekamag.com/research/048/008/048008326.php
Lund, J.N., 2006: 0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain : a viewpoint by Jonathan N. Lund.
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51
nitroglycerin and dilatation versus nifedipine and botulinum toxin
https://www.canjsurg.ca/content/cjs/49/1/41.full.pdf
Background: Surgical sphincterotomy for chronic anal fissure can cause fecal incontinence. This has led to the investigation of nonsurgical treatment ...
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https://www.canjsurg.ca/content/cjs/49/1/41.full.pdf
Background: Surgical sphincterotomy for chronic anal fissure can cause fecal incontinence. This has led to the investigation of nonsurgical treatment ...
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52
Efficacy of egg yolk and nitroglycerin ointment ... - Europe PMC
https://europepmc.org/article/pmc/pmc5133025
Acute anal fissure as a common disease in society has several etiologies and manifestations such as severe anal pain and bleeding. Nitroglycerin ointment 0.2% ...
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https://europepmc.org/article/pmc/pmc5133025
Acute anal fissure as a common disease in society has several etiologies and manifestations such as severe anal pain and bleeding. Nitroglycerin ointment 0.2% ...
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53
Nitroglycerin (Intra-anal ointment) - wikidoc
https://www.wikidoc.org/index.php/Nitroglycerin_(Intra-anal_ointment)
RECTIV™ (nitroglycerin) Ointment 0.4% is indicated for the treatment of moderate to severe pain associated with chronic anal fissure.
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https://www.wikidoc.org/index.php/Nitroglycerin_(Intra-anal_ointment)
RECTIV™ (nitroglycerin) Ointment 0.4% is indicated for the treatment of moderate to severe pain associated with chronic anal fissure.
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54
Nitroglycerin Ointment For Fissures- 45 Questions Answered
https://www.practo.com/consult/nitroglycerin-ointment-for-fissures/t
Share this page · Where to get the nitroglycerin ointments for anal fissures ? · I have fissure and internal piles so which medicine is good for fissure Stage 1 ...
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https://www.practo.com/consult/nitroglycerin-ointment-for-fissures/t
Share this page · Where to get the nitroglycerin ointments for anal fissures ? · I have fissure and internal piles so which medicine is good for fissure Stage 1 ...
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55
Therapy of Chronic Anal Fissure - Thieme Connect
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2005-920299
At the end of week 4, healing was observed in 3 additional patients, all receiving nitroglycerin ointment after initial botulinum toxin injection. Time to ...
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https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2005-920299
At the end of week 4, healing was observed in 3 additional patients, all receiving nitroglycerin ointment after initial botulinum toxin injection. Time to ...
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56
Anal Fissure Expanded Information | ASCRS
https://fascrs.org/patients/diseases-and-conditions/a-z/anal-fissure-expanded-information
Nitroglycerin is a commonly prescribed medication that is compounded with petroleum ointment to help treat both acute and chronic anal fissures.
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https://fascrs.org/patients/diseases-and-conditions/a-z/anal-fissure-expanded-information
Nitroglycerin is a commonly prescribed medication that is compounded with petroleum ointment to help treat both acute and chronic anal fissures.
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57
Idiopathic chronic anal fissure. Treatment with topical ...
http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0120-99572006000300006&lng=e&nrm=iso&tlng=en
OTERO R, William GOMEZ Z, Martín. Idiopathic chronic anal fissure. Treatment with topical nitroglycerin. []. , 21, 3, pp.173-181. ISSN 0120-9957.
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http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0120-99572006000300006&lng=e&nrm=iso&tlng=en
OTERO R, William GOMEZ Z, Martín. Idiopathic chronic anal fissure. Treatment with topical nitroglycerin. []. , 21, 3, pp.173-181. ISSN 0120-9957.
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58
A Comparative Study in Treatment of Anal Fissure – Topical ...
https://aimdrjournal.com/wp-content/uploads/2021/10/12-13.-Saurav-Mittal-86-92.pdf
Group B: This group patients were treated with topical application of 0.2% nitroglycerin/ Glyceryl trinitrate application over the anal verge twice daily for a ...
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https://aimdrjournal.com/wp-content/uploads/2021/10/12-13.-Saurav-Mittal-86-92.pdf
Group B: This group patients were treated with topical application of 0.2% nitroglycerin/ Glyceryl trinitrate application over the anal verge twice daily for a ...
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59
Anal fissure - Treatment - NHS
https://www.nhs.uk/conditions/anal-fissure/treatment/
Lidocaine is the most commonly prescribed topical anaesthetic for anal fissures. It comes in the form of either a gel or an ointment, and is usually only used ...
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https://www.nhs.uk/conditions/anal-fissure/treatment/
Lidocaine is the most commonly prescribed topical anaesthetic for anal fissures. It comes in the form of either a gel or an ointment, and is usually only used ...
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60
TAVT-119 Chronic Anal Fissures - Tavanta Therapeutics
https://www.tavanta.com/pipeline/tavt-119-anal-fissures/
The current standard of care in the U.S. is RECTIV® (nitroglycerin) Ointment 0.4%, labelled for intra-anal application and associated with a high incidence of ...
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https://www.tavanta.com/pipeline/tavt-119-anal-fissures/
The current standard of care in the U.S. is RECTIV® (nitroglycerin) Ointment 0.4%, labelled for intra-anal application and associated with a high incidence of ...
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61
A Comparison of Injections of Botulinum Toxin and Topical ...
https://www.taylorfrancis.com/chapters/edit/10.1201/9780429316944-46/comparison-injections-botulinum-toxin-topical-nitroglycerin-ointment-treatment-chronic-anal-fissure-clarence-clark-jacquelyn-seymour-turner
... and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure ... fissures to receive treatment with either a total of 20 U of botulinum ...
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https://www.taylorfrancis.com/chapters/edit/10.1201/9780429316944-46/comparison-injections-botulinum-toxin-topical-nitroglycerin-ointment-treatment-chronic-anal-fissure-clarence-clark-jacquelyn-seymour-turner
... and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure ... fissures to receive treatment with either a total of 20 U of botulinum ...
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62
Randomized clinical trial comparing botulinum toxin injections ...
https://step2.medbullets.com/evidence/17256809
In recent years treatment of chronic anal fissure has shifted from surgical ... of two non-surgical treatments-botulinum toxin injections and nitroglycerin ...
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https://step2.medbullets.com/evidence/17256809
In recent years treatment of chronic anal fissure has shifted from surgical ... of two non-surgical treatments-botulinum toxin injections and nitroglycerin ...
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63
Nitroglycerin Completed Phase 3 Trials for Chronic Anal ...
https://go.drugbank.com/drugs/DB00727/clinical_trials?conditions=DBCOND0059462&phase=3&purpose=treatment&status=completed
Nitroglycerin Completed Phase 3 Trials for Chronic Anal Fissures Treatment ; NCT01132391, Perianal Versus Endoanal Application of Glyceryl Trinitrate 0.4% ...
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https://go.drugbank.com/drugs/DB00727/clinical_trials?conditions=DBCOND0059462&phase=3&purpose=treatment&status=completed
Nitroglycerin Completed Phase 3 Trials for Chronic Anal Fissures Treatment ; NCT01132391, Perianal Versus Endoanal Application of Glyceryl Trinitrate 0.4% ...
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64
Efficacy of nitroglycerine ointment in the treatment of pediatric ...
https://www.cochranelibrary.com/content?templateType=related&urlTitle=/central/doi/10.1002/central/CN-01604631&doi=10.1002/central/CN-01604631&p_p_id=scolariscontentdisplay_WAR_scolariscontentdisplay&_scolariscontentdisplay_WAR_scolariscontentdisplay_action=related-content&p_p_lifecycle=0&p_p_mode=view&type=central&contentLanguage=
Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? H Bacher, HJ Mischinger, G Werkgartner, H Cerwenka, ...
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https://www.cochranelibrary.com/content?templateType=related&urlTitle=/central/doi/10.1002/central/CN-01604631&doi=10.1002/central/CN-01604631&p_p_id=scolariscontentdisplay_WAR_scolariscontentdisplay&_scolariscontentdisplay_WAR_scolariscontentdisplay_action=related-content&p_p_lifecycle=0&p_p_mode=view&type=central&contentLanguage=
Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? H Bacher, HJ Mischinger, G Werkgartner, H Cerwenka, ...
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65
Surgical management of anal fissure versus Glyceryl Trinitrate ...
https://www.ijsurgery.com/index.php/isj/article/view/2623
Conclusions: This prospective study, demonstrates that open lateral internal sphincterotomy is superior to topical nitroglycerin application in ...
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https://www.ijsurgery.com/index.php/isj/article/view/2623
Conclusions: This prospective study, demonstrates that open lateral internal sphincterotomy is superior to topical nitroglycerin application in ...
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66
Nitroglycerin Ointment (Rectiv) for Anal Fissure
https://secure.medicalletter.org/TML-article-1386c
The FDA has approved the use of nitroglycerin ointment 0.4% (Rectiv – ProStrakan/Aptalis) for treatment of moderate to severe pain ...
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https://secure.medicalletter.org/TML-article-1386c
The FDA has approved the use of nitroglycerin ointment 0.4% (Rectiv – ProStrakan/Aptalis) for treatment of moderate to severe pain ...
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67
A Comparison between Results of Topical Nitroglycerin ...
https://mjms.mums.ac.ir/article_5561.html?lang=en
ntroduction:Chronic anal fissure is a common problem, and there are different ways for treatment. The goal of this study was to compare the effectiveness and ...
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https://mjms.mums.ac.ir/article_5561.html?lang=en
ntroduction:Chronic anal fissure is a common problem, and there are different ways for treatment. The goal of this study was to compare the effectiveness and ...
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68
Anal fissure: Medical management - medilib
https://www.medilib.ir/uptodate/show/83135
Topical nitroglycerin is an effective treatment for anal fissures [13-20]. A meta-analysis found topical nitroglycerin to be superior to placebo ...
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https://www.medilib.ir/uptodate/show/83135
Topical nitroglycerin is an effective treatment for anal fissures [13-20]. A meta-analysis found topical nitroglycerin to be superior to placebo ...
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69
Rectal Nitroglycerin - Family Practice Notebook
https://fpnotebook.com/cv/pharm/RctlNtrglycrn.htm
Study of 80 patients over 8 weeks. Fissures healed in 68% using glyceryl ointment; Adverse effects: Headache; Only 8% healed with standard ...
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https://fpnotebook.com/cv/pharm/RctlNtrglycrn.htm
Study of 80 patients over 8 weeks. Fissures healed in 68% using glyceryl ointment; Adverse effects: Headache; Only 8% healed with standard ...
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70
Local treatment of a chronic anal fissure with diltiazem vs ...
https://www.elsevier.es/en-revista-cirugia-espanola-english-edition--436-pdf-S2173507710700521
› en-revista-cirugia-espanola-engli...
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https://www.elsevier.es/en-revista-cirugia-espanola-english-edition--436-pdf-S2173507710700521
› en-revista-cirugia-espanola-engli...
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71
The use of nitroglycerin ointment in the treatment of anal fissures
https://www.uobabylon.edu.iq/publications/medicine_edition12/medicine12_20.doc
Conclusion: Nitroglycerin ointment is a safe and effective method for the treatment of. anal fissures with high healing rate and symptomatic relief together ...
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https://www.uobabylon.edu.iq/publications/medicine_edition12/medicine12_20.doc
Conclusion: Nitroglycerin ointment is a safe and effective method for the treatment of. anal fissures with high healing rate and symptomatic relief together ...
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72
Nifedipine/Diltiazem/Nitroglycerin Ointment - Tache Pharmacy
https://www.tachepharmacy.com/wp-content/uploads/2020/05/Anal-Fissure-Patient-Information-Sheet.pdf
It also dilates the blood vessels and promotes better blood flow to the injured area and thus helps heal the fissure. Management: Fissures can be treated both ...
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https://www.tachepharmacy.com/wp-content/uploads/2020/05/Anal-Fissure-Patient-Information-Sheet.pdf
It also dilates the blood vessels and promotes better blood flow to the injured area and thus helps heal the fissure. Management: Fissures can be treated both ...
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73
Nitroglycerin Ointment for Anal Fissures - Thomas G. Burnakis ...
https://journals.sagepub.com/doi/abs/10.1177/001857879903400713
by TG Burnakis · 1999 —
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https://journals.sagepub.com/doi/abs/10.1177/001857879903400713
by TG Burnakis · 1999 —
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74
How Anal Fissure Is Treated - Verywell Health
https://www.verywellhealth.com/anal-fissure-treatment-6455452
Prescriptions for treating a fissure include: External nitroglycerin: This might be the first treatment that's offered.1 Nitroglycerin is ...
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https://www.verywellhealth.com/anal-fissure-treatment-6455452
Prescriptions for treating a fissure include: External nitroglycerin: This might be the first treatment that's offered.1 Nitroglycerin is ...
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75
Efficacy of egg yolk and nitroglycerin ... - Electronic Physician
http://www.ephysician.ir/index.php/browse-issues/2016/10/483-3035
Background: Acute anal fissure as a common disease in society has several etiologies and manifestations such as severe anal pain and bleeding. Nitroglycerin ...
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http://www.ephysician.ir/index.php/browse-issues/2016/10/483-3035
Background: Acute anal fissure as a common disease in society has several etiologies and manifestations such as severe anal pain and bleeding. Nitroglycerin ...
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76
Chronic anal fissure: 0.2% topical glyceryl trinitrate ointment ...
https://www.nice.org.uk/advice/esuom7/ifp/chapter/about-topical-glyceryl-trinitrate
Glyceryl trinitrate is commonly abbreviated to GTN and is also sometimes call nitroglycerin. The 0.4% figure gives an indication of the strength ...
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https://www.nice.org.uk/advice/esuom7/ifp/chapter/about-topical-glyceryl-trinitrate
Glyceryl trinitrate is commonly abbreviated to GTN and is also sometimes call nitroglycerin. The 0.4% figure gives an indication of the strength ...
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77
Topical glyceryl trinitrate in the treatment of anal fissure
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082004000400004
However, both surgical treatments may cause varying degrees of anal incontinence in nearly 30% of cases. Recent studies have shown that nitric oxide donor ...
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http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082004000400004
However, both surgical treatments may cause varying degrees of anal incontinence in nearly 30% of cases. Recent studies have shown that nitric oxide donor ...
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78
Clinical Trial on Fissure in Ano: Cellegesic, Placebo - ICH GCP
https://ichgcp.net/clinical-trials-registry/NCT00522041
A Study to Determine the Effect of Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With Chronic Anal Fissures ...
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https://ichgcp.net/clinical-trials-registry/NCT00522041
A Study to Determine the Effect of Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With Chronic Anal Fissures ...
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79
Anal Fissure, Abscess and Fistula
https://www.gicare.com/gi-health-resources/anal-fissure/
Special medicated creams may also be used, to help promote healing and control the symptoms. A popular remedy is nitroglycerin ointment applied to the anal ...
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https://www.gicare.com/gi-health-resources/anal-fissure/
Special medicated creams may also be used, to help promote healing and control the symptoms. A popular remedy is nitroglycerin ointment applied to the anal ...
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80
2012_06_28_Rectiv_NF.pdf - OHP Preferred Drug List
https://www.orpdl.org/durm/drug_articles/evaluations/2012_06_28_Rectiv_NF.pdf
fissures? • Is commercially available nitroglycerin ointment 0.4% (Rectiv®) more effective and safer for the treatment of any covered Oregon ...
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https://www.orpdl.org/durm/drug_articles/evaluations/2012_06_28_Rectiv_NF.pdf
fissures? • Is commercially available nitroglycerin ointment 0.4% (Rectiv®) more effective and safer for the treatment of any covered Oregon ...
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81
Internal sphincterotomy versus topical nitroglycerin ... - CORE
https://core.ac.uk/download/pdf/82376024.pdf
partial lateral anal sphincterotomy and application of topical 0.2% nitroglycerin ointment for the treatment of chronic anal fissure.
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https://core.ac.uk/download/pdf/82376024.pdf
partial lateral anal sphincterotomy and application of topical 0.2% nitroglycerin ointment for the treatment of chronic anal fissure.
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82
A quick guide to managing anal fissures - BPJ Issue 52
https://bpac.org.nz/bpj/2013/april/anal-fissures.aspx
More intensive treatment may be required in some patients ... If the fissure fails to heal within three to six weeks, topical nitrates or topical calcium channel ...
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https://bpac.org.nz/bpj/2013/april/anal-fissures.aspx
More intensive treatment may be required in some patients ... If the fissure fails to heal within three to six weeks, topical nitrates or topical calcium channel ...
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83
A randomized trial of glyceryl trinitrate ointment and ...
https://www.epistemonikos.org/documents/1816444ec5f3616cfa4f8069692c1ea7e1cc14e1/
... a nitroglycerin patch applied at a distance from the fissure site in healing anal fissure compared to GTN ointment and compared to surgical treatment.
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https://www.epistemonikos.org/documents/1816444ec5f3616cfa4f8069692c1ea7e1cc14e1/
... a nitroglycerin patch applied at a distance from the fissure site in healing anal fissure compared to GTN ointment and compared to surgical treatment.
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84
RECTIV OINTMENT (Nitroglycerin)
https://www.canadianprescriptiondrugstore.com/rectiv-ointment-nitroglycerin
Nitroglycerin (Rectiv) ointment is prescribed for the treatment of pain due to chronic anal fissure. It usually occurs in infants and is associated with ...
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https://www.canadianprescriptiondrugstore.com/rectiv-ointment-nitroglycerin
Nitroglycerin (Rectiv) ointment is prescribed for the treatment of pain due to chronic anal fissure. It usually occurs in infants and is associated with ...
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85
Anal Fissure - P.S.Te MD
https://patricia-sun-te.weebly.com/anal-fissure.html
Topical treatment with 0.2 to 0.3 percent nifedipine two to four times a day has few side effects. Nitroglycerin works to dilate blood vessels, increasing blood ...
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https://patricia-sun-te.weebly.com/anal-fissure.html
Topical treatment with 0.2 to 0.3 percent nifedipine two to four times a day has few side effects. Nitroglycerin works to dilate blood vessels, increasing blood ...
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86
Practical Management of Anal Fissure - Medscape Education
https://www.medscape.org/viewarticle/806468_3
Anal fissure is a bothersome and painful problem for patients for which treatment must be individualized. Authors: Stephen Wexner, MD.
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https://www.medscape.org/viewarticle/806468_3
Anal fissure is a bothersome and painful problem for patients for which treatment must be individualized. Authors: Stephen Wexner, MD.
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87
ANAL FISSURE PAIN Part 3: Medical Treatments - YouTube
https://www.youtube.com/watch?v=WZCc924AcdY
If you have anal or rectal pain, it could be an anal fissure! There may be medical treatments that can help avoid surgery and the added risk ...
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https://www.youtube.com/watch?v=WZCc924AcdY
If you have anal or rectal pain, it could be an anal fissure! There may be medical treatments that can help avoid surgery and the added risk ...
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88
Anal Fissure 10 Day Anal Fissure Cure - NO Botox ... - YouTube
https://www.youtube.com/watch?v=W2NXWLwaAgE
Anal Fissure 10 Day Anal Fissure Cure - NO Botox NO Nitroglycerin NO Doctors https://naturalfissurecurekit.comIn this video I discuss an ...
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https://www.youtube.com/watch?v=W2NXWLwaAgE
Anal Fissure 10 Day Anal Fissure Cure - NO Botox NO Nitroglycerin NO Doctors https://naturalfissurecurekit.comIn this video I discuss an ...
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89
Nitroglycerin/Glyceryl trinitrate: Drug That Saves Your Life ...
https://www.medindia.net/healthvideo/nitroglycerin.htm
Nitroglycerin is prescribed to treat heart diseases such as chest pain or angina, myocardial infarction, and high blood pressure.
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https://www.medindia.net/healthvideo/nitroglycerin.htm
Nitroglycerin is prescribed to treat heart diseases such as chest pain or angina, myocardial infarction, and high blood pressure.
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90
Nitroglycerin ointment for angina - filosoffen.dk
https://www.filosoffen.dk/fileadmin/content/bloodpressure/nitroglycerin-ointment-for-angina.php
Nitroglycerin, also known as glyceryl trinitrate (GTN), is a medication used for heart failure, high blood pressure, anal fissures, ...
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https://www.filosoffen.dk/fileadmin/content/bloodpressure/nitroglycerin-ointment-for-angina.php
Nitroglycerin, also known as glyceryl trinitrate (GTN), is a medication used for heart failure, high blood pressure, anal fissures, ...
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91
Nitroglycerin - Side Effects, Uses, Dosage ... - RxWiki
https://www.rxwiki.com/nitroglycerin
The topical ointment and transdermal patch are used for long-term prevention of chest pain. These forms cannot be used to treat chest pain that ...
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https://www.rxwiki.com/nitroglycerin
The topical ointment and transdermal patch are used for long-term prevention of chest pain. These forms cannot be used to treat chest pain that ...
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92
A patient takes a sublingual nitroglycerin for chest pain ...
https://ihoctot.com/a-patient-takes-a-sublingual-nitroglycerin-for-chest-pain-and-begins-to-feel-dizzy
Nitroglycerin helps open up the blood vessels and allows blood to flow. People can also use nitroglycerin to treat anal fissures.
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https://ihoctot.com/a-patient-takes-a-sublingual-nitroglycerin-for-chest-pain-and-begins-to-feel-dizzy
Nitroglycerin helps open up the blood vessels and allows blood to flow. People can also use nitroglycerin to treat anal fissures.
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93
Anal Fissure Treatment - Medfin
https://blog.medfin.in/general-surgeries/fissures/anal-fissures-treatment/
Find more about the types of fissures, its treatment. ... Cream: Applying creams such as nitroglycerin helps promote blood flow.
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https://blog.medfin.in/general-surgeries/fissures/anal-fissures-treatment/
Find more about the types of fissures, its treatment. ... Cream: Applying creams such as nitroglycerin helps promote blood flow.
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94
Anal Fissure: Symptoms, Diagnosis and Therapies
https://books.google.com/books?id=RvmODgAAQBAJ&pg=PA151&lpg=PA151&dq=nitroglycerin+treatment+fissures&source=bl&ots=HNah0eymOM&sig=ACfU3U3CCFGD2oOyd_KMZhaGI1Uw__9qXw&hl=en&sa=X&ved=2ahUKEwjhx4aX4sj7AhWMkIkEHURiC60Q6AF6BAgsEAM
Dis Colon Rectum 50:509–516 Bacher H, Mischinger HJ, Werkgartner G et al (1997) Local nitroglycerin for treatment of anal fissures: an alternative to ...
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https://books.google.com/books?id=RvmODgAAQBAJ&pg=PA151&lpg=PA151&dq=nitroglycerin+treatment+fissures&source=bl&ots=HNah0eymOM&sig=ACfU3U3CCFGD2oOyd_KMZhaGI1Uw__9qXw&hl=en&sa=X&ved=2ahUKEwjhx4aX4sj7AhWMkIkEHURiC60Q6AF6BAgsEAM
Dis Colon Rectum 50:509–516 Bacher H, Mischinger HJ, Werkgartner G et al (1997) Local nitroglycerin for treatment of anal fissures: an alternative to ...
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