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1 WT1 expression as an independent marker of poor ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/21896989/
In this study, we aimed to investigate the prognostic role of WT1 in colorectal cancers (CRCs). Archival tissue samples from 157 CRC cases who underwent ...
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2 Wilms' tumor 1 (WT1) expression and prognosis in solid ...
https://www.nature.com/articles/srep08924
WT1-positive tumors included tumor of the stomach, prostate, and biliary and urinary systems, and malignant melanomas. A majority of the ...
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3 WT1 is a tumor‐associated antigen in colon cancer that can ...
https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.11721
WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells. Robert Koesters,.
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4 Wilms' tumor gene (WT1) expression in lung cancer, colon ...
https://link.springer.com/content/pdf/10.1007/s004320050037.pdf
R. A. Schmidt á G. Pecher á K. Schramm á E. Thiel. Wilms' tumor gene (WT1) expression in lung cancer, colon cancer and glioblastoma cell lines compared.
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5 Long Non-coding Wilms Tumor 1 Antisense RNA in ... - Frontiers
https://www.frontiersin.org/articles/10.3389/fonc.2020.00035/full
In particular, WT1-AS expression is upregulated in colon cancer and breast cancer but is significantly downregulated in cervical cancer, liver ...
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6 WT1 (Wilms' Tumor Gene 1): Biology and Cancer ...
https://academic.oup.com/jjco/article/40/5/377/863825
Wilms' tumor gene WT1 encodes a transcription factor and plays an important role in cell growth and differentiation. The WT1 gene is highly ...
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7 Overexpression of the Wilms' Tumor ... - Anticancer Research
https://ar.iiarjournals.org/content/anticanres/24/5B/3103.full.pdf
expressed in cancer cells derived from various kinds of cancers (8,9) and overexpressed in primary leukemia (10), lung (11), colon (12), breast (13,14) and ...
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8 Medical Science Monitor - Article abstract #915335
https://medscimonit.com/abstract/index/idArt/915335
Investigation of Insulin-Like Growth Factor-1 (IGF-1), P53, and Wilms' Tumor 1 (WT1) Expression Levels in the Colon Polyp Subtypes in Colon Cancer · Department ...
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9 Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T ...
https://www.pnas.org/doi/full/10.1073/pnas.0405884101
However, her disease was progressive, and ileus occurred due to the metastatic tumors in the colon, so that WT1 vaccination was initiated. The increase in NCC- ...
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10 WT1 is a tumor-associated antigen in colon ... - ResearchGate
https://www.researchgate.net/publication/8693824_WT1_is_a_tumor-associated_antigen_in_colon_cancer_that_can_be_recognized_byin_vitro_stimulated_cytotoxic_T_cells
Request PDF | WT1 is a tumor-associated antigen in colon cancer that can be recognized byin vitro stimulated cytotoxic T cells | The Wilms' ...
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11 WT1 - My Cancer Genome
https://www.mycancergenome.org/content/gene/wt1/
WT1 is altered in 1.78% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, acute myeloid leukemia, ...
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12 Expression Levels of the CA9, WT1, and PRAME Genes and ...
https://www.scielo.br/j/jcol/a/XH3gkPZKjZbWcwQCqVNsfDp/?lang=en
Colorectal cancer (CRC) is the third most prevalent type of cancer worldwide, ... the Wilms tumor gene (WT1), and the preferentially expressed antigen in ...
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13 Immunotherapy in colon cancer: approaching to the future
https://jumdjournal.net/article/view/2846
Colon cancer, pembrolizumab, microsatellite instability, nivolumab, ... based on Wilms' tumour (WT1) class I/II peptides in colon cancer patients and showed ...
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14 Identifying the role of Wilms tumor 1 associated protein in ...
https://www.spandidos-publications.com/10.3892/mmr.2016.5528/download
The Wilms tumor suppressor gene WT1 was first identified ... in colorectal cancer, inhibited the Wnt signaling pathway by.
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15 Colon: Colorectal adenocarcinoma
https://atlasgeneticsoncology.org/solid-tumor/5006/colon-colorectal-adenocarcinoma
Colorectal Cancer (CRC) can be classified from the molecular or etiological point of view: Molecular pathway ... Interacts with WT1.
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16 Development of Cancer Vaccine Targeting WT1 Product ...
https://benthamscience.com/article/35103
The Wilms tumor gene WT1 is highly expressed not only in hematopoietic malignancies, including leukemia and myelodysplastic syndromes (MDS), ...
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17 Carbonic anhydrase IV inhibits colon cancer development by ...
https://gut.bmj.com/content/65/9/1482
WTAP was a negative regulator of WT1 which negatively regulated the Wnt signalling pathway.24 We identified that the tumour-suppressive effect of CA4 was ...
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18 Expression of WT1 in cancer - The Human Protein Atlas
https://www.proteinatlas.org/ENSG00000184937-WT1/pathology
Expression of WT1 (AWT1, GUD, NPHS4, WAGR, WIT-2) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
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19 The role of WT1 in breast and other cancers
http://smj.medicine.psu.ac.th/index.php/smj/article/view/273
The Wilms' tumor 1 (WT1) gene is originally identified in Wilms tumor, a childhood kidney cancer. This gene encodes a zinc finger transcriptional regulatory ...
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20 WT1 expression as an independent marker of ... - IOS Press
https://content.iospress.com/download/cancer-biomarkers/dma00822?id=cancer-biomarkers%2Fdma00822
aimed to investigate the prognostic role of WT1 in colorectal cancers (CRCs). Archival tissue samples from 157 CRC cases who.
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21 WT1 Cancer Vaccine for the Treatment and Prevention
https://esmed.org/MRA/mra/article/view/2762
Wilms' tumor gene 1 (WT1) overexpresses in almost all kinds of hematological malignancies and solid tumors (hereinafter referred to as ...
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22 Updates on immunotherapy for colorectal cancer - Kalyan
https://jgo.amegroups.com/article/view/18970/html
Other TAAs have also been utilized in DC vaccines as demonstrated by a recent phase I trial evaluating the safety and immunogenicity of Wilms' tumor (WT1) class ...
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23 Dendritic Cell-Based Adjuvant Vaccination Targeting Wilms ...
https://www.mdpi.com/2076-393X/3/4/1004
Wilms' tumor 1 (WT1) represents the most potent tumor-associated antigen widely detected in cancer, sarcoma, and leukemia in terms of therapeutic function, ...
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24 Construction and analysis for differentially expressed long non ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192494
We found that 9 of them were significantly associated with overall survival, could be considered as a prognostic marker for colon cancer.
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25 GSK3β-Mediated Expression of CUG-Translated WT1 Is ...
https://aacrjournals.org/cancerres/article/81/4/945/650235/GSK3-Mediated-Expression-of-CUG-Translated-WT1-Is
The Wilms' tumor 1 (WT1) gene is well known as a chameleon gene. It plays a role as a tumor suppressor in Wilms' tumor but also acts as an ...
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26 Definition of WT1 126-134 peptide vaccine - NCI Drug Dictionary
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/wt1-126-134-peptide-vaccine
WT1, a tumor associated antigen, is overexpressed in most types of leukemia and in a variety of solid cancers. Vaccination with WT1 126-134 peptide vaccine may ...
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27 WT1-p53 Interactions in Insulin-like Growth Factor-I Receptor ...
https://www.sciencedirect.com/science/article/pii/S0021925819309470
Similar studies were also performed to compare p53-expressing Balb/c-3T3 and clonally derived p53-null, (10)1 fibroblasts and the colorectal cancer cell ...
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28 Wilms' tumor gene (WT1) expression in lung cancer ... - Wikidata
https://www.wikidata.org/wiki/Q52972535
Wilms' tumor gene (WT1) expression in lung cancer, colon cancer and glioblastoma cell lines compared to freshly isolated tumor specimens. · Statements.
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29 WT1 - Pathology Outlines
https://www.pathologyoutlines.com/topic/stainswt1.html
WT1 staining is nuclear in malignant mesothelioma. Cytokeratin is positive in both mesotheliomas and carcinomas; however, it is important to ...
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30 DNA vaccination induces WT1-specific T-cell responses with ...
https://ashpublications.org/blood/article-abstract/112/7/2956/24784/DNA-vaccination-induces-WT1-specific-T-cell
The Wilms tumor antigen, WT1, is associated with several human cancers, including leukemia. We evaluated WT1 as an immunotherapeutic target using our proven ...
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31 Wilms' tumour suppressor gene 1 (WT1) is involved in the ...
https://cancerci.biomedcentral.com/articles/10.1186/1475-2867-13-114
Although studies have shown the oncogene WT1 is overexpressed in lung cancer, there is no data showing the implication of WT1 in lung cancer ...
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32 Colorectal Cancer Treatment Options - Summit Cancer Centers
https://www.summitcancercenters.com/cancers-we-treat/colorectal-cancer/
Most colorectal cancers are adenocarcinomas, which means the cancer ... known to Express WT1 Tumor Antigen (Melanoma, Ovarian, Colorectal) | Last Updated: 3 ...
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33 Metastatic colon cancer of an ovarian cancer origin mimicking ...
https://www.kjco.org/journal/view.php?number=300
by JH Park · 2018 · Cited by 3 —
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34 WT1 Detection by RNAscope™ in Human Cancers
https://acdbio.com/system/files_force/WT1%20Detection_Dataset.pdf?download=1
Wilms' tumor gene (WT1) is expressed in various human malignancies, including both ... Colon. Cancer. Ovarian. Cancer. Cell Line Name. Tissue Type.
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35 The role of WT1 gene in neuroblastoma
https://www.jpedsurg.org/article/S0022-3468(10)00998-X/abstract
WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells. Int J Cancer. 2004; 109: 385- ...
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36 Prognostic value of the density of Wilms tumour protein 1 (WT ...
https://e-century.us/files/ijcep/9/3/ijcep0022178.pdf
Abstract: Stage IIA colorectal cancer (CRC) displays 5-year survival rate around 85%; hence ... WT1 expression was previously demonstrated.
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37 Overexpression of the Wilms' tumor gene ... - Semantic Scholar
https://www.semanticscholar.org/paper/Overexpression-of-the-Wilms%27-tumor-gene-WT1-in-Oji-Yano/7ef81b48afe51b06f683383ae2638a35c0f86e1f
Wilms' tumor gene (WT1) expression in lung cancer, colon cancer and glioblastoma cell lines compared to freshly isolated tumor specimens · H.
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38 Immunohistochemical Expression of Wilms' Tumor 1 Protein in ...
https://mdpi-res.com/d_attachment/applsci/applsci-10-00040/article_deploy/applsci-10-00040.pdf?version=1576750827
2.11. WT1 Expression in Colorectal Carcinoma. Colorectal cancer is one of the most commonly diagnosed cancers worldwide, accounting for an.
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39 Identification of WT1 as determinant of heptatocellular ...
https://www.oncotarget.com/article/22406/text/
Keywords: hepatocellular carcinoma; WT1; Wnt/β-catenin pathway; ... promoter activity and mRNA expression in colorectal cancer cells [26].
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40 Dendritic cell-based cancer immunotherapy for colorectal cancer
https://www.wjgnet.com/1007-9327/full/v22/i17/4275.htm
Moreover, WT1 expression in CRC is significantly associated with tumor progression, lymph node metastasis, distant metastasis and clinical stage ...
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41 The Wilms' Tumor Gene Product (WT1) Modulates the ...
https://www.jbc.org/article/S0021-9258(18)46362-4/pdf
correlated expression of WT1 and VDR mRNA in sam- ples from renal tissues. HT29 colon carcinoma cells, sta- bly transfected to express WT1, ...
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42 Wilms tumor 1 gene, CD97, and the emerging biogenetic ...
https://thejns.org/downloadpdf/journals/neurosurg-focus/37/6/article-pE14.pdf
cus to the Wilms tumor 1 gene (WT1).5–8 WT1 was first isolated in 1990 by Haber et al. with ... in pancreatic cancers, colon cancers, and oral squamous.
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43 Tumor Gene WT1 Product Cancer Immunotherapy Targeting ...
http://www.jimmunol.org/content/jimmunol/164/4/1873.full.pdf
The Wilms' tumor gene WT1 was first reported as the gene responsible for Wilms' tumor, ... gastric, colon, breast, and ovary cancer cell lines. High WT1 ex-.
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44 Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and ...
https://www.jci.org/articles/view/44165
In human lung cancer cell lines dependent on oncogenic KRAS, WT1 loss decreased proliferation and induced senescence. Furthermore, WT1 ...
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45 Methylation Status of Transcriptional Modulatory Genes ...
https://www.gutnliver.org/journal/view.html?doi=10.5009/gnl17163
Total heterogeneous methylation of CA10 and WT1 conferred a significantly higher ... It was estimated that colorectal cancer (CRC) ranked as the third most ...
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46 MACS® GMP PepTivator® WT1 - Miltenyi Biotec
https://www.miltenyibiotec.com/US-en/products/macs-gmp-peptivator-wt1.html
However, WT1 is expressed at high levels in various types of leukemia and solid tumors, including lung, breast, colon cancer and soft tissue sarcomas.
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47 The role of the Wilms tumour gene (WT1) in normal and ...
https://www.cambridge.org/core/journals/expert-reviews-in-molecular-medicine/article/role-of-the-wilms-tumour-gene-wt1-in-normal-and-malignant-haematopoiesis/61E238CF6C33614202C46D8BF020E21E
(2004) WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells. Int J Cancer 109, ...
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48 The role of the Wilms' tumour-suppressor protein WT1 in ...
https://portlandpress.com/biochemsoctrans/article/36/4/629/64297/The-role-of-the-Wilms-tumour-suppressor-protein
WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells. ,. Int. J. Cancer.
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49 WT1 Promotes Invasion of NSCLC via Suppression of CDH1
https://www.jto.org/article/S1556-0864(15)33472-9/pdf
Wilms' tumor gene (WT1) expression in lung cancer, colon cancer and glioblastoma cell lines com- pared to freshly isolated tumor specimens. J Cancer Res Clin ...
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50 Wilms Tumor 1 (WT1) as a tumor marker to detect metastatic ...
https://www.gynecologiconcology-online.net/article/S0090-8258(14)01490-5/pdf
of uterine cancer with hysterectomy in 1996 and also had colon cancer ... WT1 was used to distinguish metastatic fallopian tube serous.
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51 WTX | Cancer Genetics Web
https://www.cancer-genetics.org/WTX.htm
Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer ... In addition to genes previously implicated in Wilms tumors (WT1, ...
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52 Galinpepimut-S (GPS) Therapy - Sellas Life Sciences
https://www.sellaslifesciences.com/galinpepimut-s-gps-therapy/
The WT1 antigen is one of the most widely expressed cancer antigens in multiple malignancies. It has been ranked by the NCI as the top priority among cancer ...
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53 BCG-CWS Enhances the Potential of WT1 Peptide Cancer ...
https://journals.lww.com/immunotherapy-journal/Fulltext/2004/11000/BCG_CWS_Enhances_the_Potential_of_WT1_Peptide.136.aspx
Wilms' tumor gene WT1 is highly expressed not only in most types of hematological malignancies but also in various types of solid tumors, and WT1 protein has ...
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54 Next Generation Sequencing Oncology Tumor Testing
https://labguide.fairview.org/showtest.asp?testid=6315&format=long
... PIK3cA; TP53; WT1; Lung Cancer Panel; Colorectal Cancer Panel; GIST; Gastrointestinal Tumor Panel; Melanoma Panel; Glioma Panel; Solid Tumor Panel; ...
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55 Dendritic Cell-Based Adjuvant Vaccination Targeting ... - IOZK
https://www.iozk.de/2015/12/dendritic-cell-based-adjuvant-vaccination-targeting-wilms-tumor-1-in-patients-with-advanced-colorectal-cancer/
... safety and immunogenicity of Wilms' tumor (WT1) class I/II peptides-pulsed dendritic cell DC vaccination for patients with advanced colorectal cancer.
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56 WT1 as a Novel Target Antigen for Cancer Immunotherapy
https://www.eurekaselect.com/article/9297
Wild-type Wilms tumor gene WT1 is expressed at high levels not only in most of acute myelocytic, acute lymphocytic, and chronic myelocytic leukemia, ...
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57 Wilms' tumor 1 (WT1)-targeted cancer vaccines to extend ...
https://www.futuremedicine.com/doi/abs/10.2217/imt-2016-0031
Recent reports have indicated that WT1-targeted cancer vaccines for patients with PDA mediated a potent antitumor effect when combined with ...
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58 What Causes Wilms Tumors? - American Cancer Society
https://www.cancer.org/cancer/wilms-tumor/causes-risks-prevention/what-causes.html
A small number of Wilms tumors have changes in or loss of the WT1 or WT2 genes, which are tumor suppressor genes found on chromosome 11.
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59 Long non-coding RNA WT1-AS inhibits cell aggressiveness ...
https://www.europeanreview.org/wp/wp-content/uploads/486-495.pdf
cinoma7, colon cancer8 and breast carcinoma9, and are associated with overall survival. Wilms tumor. 1 Antisense RNA (WT1-AS) is an antisense tran-.
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60 Genetic and biological hallmarks of colorectal cancer
http://genesdev.cshlp.org/content/35/11-12/787.full
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, ...
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61 The Wilms' Tumor Gene 1 (WT1) Induces Expression of the N ...
https://www.liebertpub.com/doi/10.1089/dna.2007.0586
The Wilms' tumor gene 1 (WT1) protein is a transcriptional regulator that is highly expressed in immature hematopoietic progenitor cells and in the majority ...
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62 Expression of Wilms Tumor 1 Gene Distinguishes Vascular ...
https://jamanetwork.com/journals/jamadermatology/fullarticle/399310
We have shown that the transcription factor WT1 is present in vascular tumors but not in vascular malformations. A significant portion of the hemangiomas, ...
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63 SITC 2022: CUE-102 selectively activates and expands WT1 ...
https://clin.larvol.com/abstract-detail/SITC%202022/60427211/272927
... malignancies. - Abstract #1323 ; Pres time: November 10, 2022 ;09:00:00 - 21:00:00 ; "Background Wilms' Tumor 1 (WT1) was ranked as the highest priority ...
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64 Focus on Colorectal Cancer Research - Page 88 - Google Books Result
https://books.google.com/books?id=OqB0wVVK0GoC&pg=PA88&lpg=PA88&dq=wt1+colon+cancer&source=bl&ots=FMTM2SW8TO&sig=ACfU3U2qzvCTcGabLclU6ccu_EokeIA9Cw&hl=en&sa=X&ved=2ahUKEwj1zJjzxMb7AhUWk4kEHZfyD2kQ6AF6BQiEAhAD
... insulin - like growth factor receptor in human colon cancer cell lines . ... activity by wild - type and mutant versions of the WT1 tumor suppressor .
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65 cBioPortal for Cancer Genomics
https://www.cbioportal.org/
The cBioPortal for Cancer Genomics provides visualization, analysis and download of large-scale cancer genomics data sets.
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66 Selected Active Immunotherapies In Late-Stage Development
https://pink.pharmaintelligence.informa.com/PS004461/Selected%20Active%20Immunotherapies%20In%20LateStage%20Development
GlaxoSmithKline. WT1 ASCI. Antigen specific cancer immunotherapy. Phase II for acute myelogenous leukemia ; GlobeImmune. GI-4000.
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67 What is Colorectal Cancer?
https://www.ccalliance.org/colorectal-cancer-information/what-is-colorectal-cancer
Overview. Colorectal cancer, or CRC, is a disease of the colon or rectum, which are parts of the digestive system. Unlike most cancers ...
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68 Colon Cancer Treatment - Vanderbilt-Ingram Cancer Center
https://www.vicc.org/cancer-info/adult-colon-cancer
Signs of colon cancer include blood in the stool or a change in bowel habits. Tests that examine the colon and rectum are used to diagnose colon ...
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69 Immunohistochemistry Applications in Gastrointestinal Cancer
https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/protein-biology/immunohistochemistry/colorectal-cancer
The more prevalent use of IHC is in the presence of possible or suspected metastatic disease in which the colon is a possible primary. The common locations for ...
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70 Patients – Colorectal Cancer
https://ruesch.georgetown.edu/colorectal/
Studies are showing that certain drugs have more effect on cancers depending on what side of the colon they are located. Colon Cancer & Genetic Testing.
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71 Colon Cancer Carcinogensis - YouTube
https://www.youtube.com/watch?v=eoZrF_157XE
Armando Hasudungan
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72 Stanford-developed molecule homes in on enzyme that ...
https://med.stanford.edu/news/all-news/2022/070/molecule-targets-cancer-cells.html
Stanford Medicine researchers have created a molecule that blocks an enzyme thought to be instrumental in causing colon cancer relapse or ...
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73 Immunotherapy and Colorectal Cancer at ASCO GI 2022
https://www.obroncology.com/video/immunotherapy-and-colorectal-cancer-at-asco-gi-2022
› video › immunotherapy-...
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74 Immunohistochemical Expression - Page 123 - Google Books Result
https://books.google.com/books?id=B8RAEAAAQBAJ&pg=PA123&lpg=PA123&dq=wt1+colon+cancer&source=bl&ots=Eh6sRnjgaF&sig=ACfU3U3YMW8IJQyw07oeQ60sdX3pnzd2YA&hl=en&sa=X&ved=2ahUKEwj1zJjzxMb7AhUWk4kEHZfyD2kQ6AF6BQiDAhAD
Mrowka, C.; Schedl, A. Wilms' tumor suppressor gene WT1: From structure to renal ... M. WT1 is a tumor-associated antigen in colon cancer that can be ...
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