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1 What Is Cancer? - NCI
https://www.cancer.gov/about-cancer/understanding/what-is-cancer
Cancer is caused by certain changes to genes, the basic physical units of inheritance. Genes are arranged in long strands of tightly packed DNA ...
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2 Cancer - World Health Organization (WHO)
https://www.who.int/health-topics/cancer
Cancer is a group of diseases that occurs when abnormal cells grow uncontrollably or spread to other parts of the body.
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3 THE SIGNIFICANCE OF CANCER CELLS IN THE BLOOD
https://jamanetwork.com/journals/jama/fullarticle/328102
THE SIGNIFICANCE OF CANCER CELLS IN THE BLOOD ... we know that the vascular spread of cancer cells is the mechanism which kills most patients with cancer, ...
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4 Cancer: Overview, causes, treatments, and types
https://www.medicalnewstoday.com/articles/323648
Cancer is the uncontrolled development of cells. After heart disease, it is the second most common cause of death in the United States.
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5 Understanding Cancer - NIH Curriculum Supplement Series
https://www.ncbi.nlm.nih.gov/books/NBK20362/
In simple terms, cancer is a group of more than 100 diseases that develop across time and involve the uncontrolled division of the body's cells.
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6 Cancer - Chronic Disease Fact Sheets - CDC
https://www.cdc.gov/chronicdisease/resources/publications/factsheets/cancer.htm
Cancer is the second leading cause of death in the United States, but many kinds of cancer can be prevented or caught early. Leading risk factors for ...
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7 What Is Cancer Research? | Patients and Caregivers | AACR
https://www.aacr.org/patients-caregivers/about-cancer/what-is-cancer-research/
The purpose of studying cancer is to develop safe and effective methods to prevent, detect, diagnose, treat, and, ultimately, cure the collections of diseases ...
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8 Understanding What Cancer Is: Ancient Times to Present
https://www.cancer.org/treatment/understanding-your-diagnosis/history-of-cancer/what-is-cancer.html
The study of cancer, called oncology, is the work of countless doctors and scientists around the world whose discoveries in anatomy, physiology, chemistry, ...
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9 Computational estimation of quality and clinical relevance of ...
https://www.embopress.org/doi/10.15252/msb.202211017
Immortal cancer cell lines (CCLs) are the most widely used system for investigating cancer biology and for the preclinical development of ...
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10 Stress and cancer: mechanisms, significance and future ...
https://www.nature.com/articles/s41568-021-00395-5
The notion that stress and cancer are interlinked has dominated lay discourse for decades. More recent animal studies indicate that stress ...
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11 American Association for Cancer Research - AACR Journals
https://aacrjournals.org/cancerres
About the Journal. Cancer Research publishes original studies, reviews, and opinion pieces offering significance and broad impact to a ...
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12 Redefining the relevance of established cancer cell lines to ...
https://www.pnas.org/doi/10.1073/pnas.1111840108
The study of human cancer-derived cell lines has made important contributions to cancer biology and has formed the basis for our current understanding of drug ...
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13 Smilow Cancer Genetics & Prevention Program - Yale Medicine
https://www.yalemedicine.org/departments/smilow-cancer-genetics-and-prevention-program
The goal is to identify cancer risk as early as possible. This knowledge can help patients take measures to prevent cancer, or it can help doctors treat ...
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14 The significance of microsatellite instability in colorectal...
https://journals.lww.com/md-journal/Fulltext/2018/03020/The_significance_of_microsatellite_instability_in.7.aspx
The colorectal cancer (CRC) patients with microsatellite instability (MSI) have distinct clinicopath.
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15 The significance of tumour microarchitectural features in ...
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-018-0934-x
Breast cancer is the most common cancer in the UK, with a lifetime risk around 1 in 8 women [1]. Although a sustained decline in mortality has ...
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16 What is cancer? - Cancer Research UK
https://www.cancerresearchuk.org/about-cancer/what-is-cancer
Cancer is when abnormal cells divide in an uncontrolled way. Some cancers may eventually spread into other tissues. There are more than 200 different types ...
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17 Significance of multiple mutations in cancer - Oxford Academic
https://academic.oup.com/carcin/article/21/3/379/2365659
Genetic instability is manifested by extensive heterogeneity of cancer cells within each tumor. In addition, tumors invariably develop resistance to ...
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18 Significance, detection and markers of disseminated breast ...
https://erc.bioscientifica.com/view/journals/erc/13/4/0131033.xml
The development of distant metastases is the major cause of death from breast cancer. In order to predict and prevent tumour spreading, many ...
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19 About cancer research - Irish Cancer Society
https://www.cancer.ie/research/about-our-cancer-research/what-is-cancer-research
Cancer research is crucial to improve the prevention, detection and treatment of these cancers, and ensure that survivors live longer, better quality lives.
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20 What is cancer control? - UICC
https://www.uicc.org/who-we-are/about-uicc/cancer-control
Some 10 million people die from cancer globally every year. The disease places an enormous burden on countries and communities. Cancer control aims to ...
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21 Cancer: Types, Causes, Treatment, and Prevention - Healthline
https://www.healthline.com/health/cancer
Some cancer cells can also spread through the bloodstream or lymphatic system to distant areas of the body. This is called metastasis. Cancers ...
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22 Prognostic Significance of Patient-Reported Outcomes in ...
https://ascopubs.org/doi/full/10.1200/JOP.19.00329
Performance status (PS), an established prognostic surrogate of cancer survival, is a physician-synthesized metric of patient symptoms and ...
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23 Religion and Spirituality | Surviving Cancer - Stanford Medicine
https://med.stanford.edu/survivingcancer/cancer-sources-of-support/cancer-religion-spirituality-help.html
A cancer diagnosis confronts us with the fact that we are vulnerable to disease and suffering, that we are mortal, and that our time is limited. When we are in ...
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24 Clinical significance of tumor-infiltrating lymphocytes in breast ...
https://jitc.bmj.com/content/4/1/59
Triple negative breast cancers (TN) are most likely to have tumors with >50 % lymphocytic infiltrate, termed lymphocyte predominant breast cancer, and derive ...
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25 The spontaneous remission of cancer: Current insights and ...
https://www.sciencedirect.com/science/article/pii/S1936523321001583
In 2020, 19.3 million new cancer cases and approximately 10 million cancer deaths occurred worldwide, with breast cancer being the most prevalent one and lung ...
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26 The Clinical Significance of Long Non-Coding RNAs in Cancer
https://www.news-medical.net/health/The-Clinical-Significance-of-Long-Non-Coding-RNAs-in-Cancer.aspx
Within the disordered genome of cancer cells, these pathways may be up or downregulated, the lncRNA potentially acting as an oncogene or tumor ...
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27 The Future of Cancer Research: Five Reasons for Optimism
https://www.mskcc.org/news/future-five-reasons-optimism
Many cancers are fueled by biochemical changes of histones, the proteins that serve as spools for DNA in our cells (histones are shown in ...
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28 Clinical relevance of liquid biopsy for cancer screening - Tanos
https://tcr.amegroups.com/article/view/19860/html
Cancer screening aims at detecting cancer at early stages, before symptoms appear, and when the treatment is most likely to be effective. But most cancer types ...
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29 Department of Cancer Biology - Mayo Clinic Research
https://www.mayo.edu/research/departments-divisions/department-cancer-biology/overview
Research is particularly strong in tumor invasion and metastasis, a key event during tumor progression that accounts for more than 90% of cancer-related ...
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30 Tyrosine kinase – Role and significance in Cancer
https://www.medsci.org/v01p0101.htm
Recent advances have implicated the role of tyrosine kinases in the pathophysiology of cancer. Though their activity is tightly regulated in normal cells, they ...
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31 Blueprint for cancer research: Critical gaps and opportunities
https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21652
The clinical relevance of many mutations remains unclear for many types of cancer. Functional genomic analyses are required to determine whether ...
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32 Skin Cancer Information - The Skin Cancer Foundation
https://www.skincancer.org/skin-cancer-information/
Skin cancer is the out-of-control growth of abnormal cells in the epidermis, the outermost skin layer, caused by unrepaired DNA damage that triggers ...
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33 Social & Emotional Impacts of Cancer
https://www.mdanderson.org/patients-family/life-after-cancer/social-emotional-impacts.html
Learn how to cope with the social and emotional impacts of cancer at MD Anderson Cancer Center.
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34 Is cancer biology different in older patients? - The Lancet
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00179-3/fulltext
In this narrative Review of published literature, we explored the reported differences in tumour biology according to age in five major cancer ...
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35 How Evolution Helps Us Understand Cancer and Control It
https://www.scientificamerican.com/article/how-evolution-helps-us-understand-cancer-and-control-it/
When cancer cells overuse resources in their local environments—producing enzymes that digest nearby tissue, for instance—the process often ...
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36 Cancer Cachexia: Its Mechanism and Clinical Significance
https://www.mdpi.com/1422-0067/22/16/8491
Cancer Cachexia: Its Mechanism and Clinical Significance. by. Hiroki Nishikawa. 1,2,*,. Masahiro Goto.
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37 Role of circulating tumor cells in future diagnosis and therapy ...
https://jcmtjournal.com/article/view/1172
We have mostly focused on the significance of CTCs in diagnosis and therapies of four most common types of cancers, namely, breast, prostate, lung, ...
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38 Why we need to work together to eliminate cervical cancer
https://www.weforum.org/agenda/2022/11/cervical-cancer-elimination-multi-stakeholder-collaboration/
A health concern of global significance, cervical cancer is one of the most common cancers women face worldwide.
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39 Molecular and Clinical Significance of Stanniocalcin-1 ...
https://www.frontiersin.org/articles/10.3389/fcell.2021.731086/full
All these findings indicate that STC1 promotes breast cancer tumorigenesis and that breast cancers with a high level of STC1 are more resistant ...
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40 Why is Breast Cancer Awareness so Important?
https://www.foxchase.org/blog/why-breast-cancer-awareness-so-important
Every October, you likely see a wealth of information about breast cancer. And that is a good thing. Awareness surrounding breast cancer is ...
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41 Cancer Cells vs Normal Cells - Technology Networks
https://www.technologynetworks.com/cancer-research/articles/cancer-cells-vs-normal-cells-307366
Cancer is a complex genetic disease that is caused by specific changes to the genes in one cell or group of cells.
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42 Researchers create algorithm to help predict cancer risk ...
https://news.vanderbilt.edu/2022/08/09/research-snapshot-researchers-create-algorithm-to-help-predict-cancer-risk-associated-with-tumor-variants/
Vanderbilt researchers have developed an active machine learning approach to predict the effects of tumor variants of unknown significance, ...
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43 Comparing cancer vs normal gene expression profiles ...
https://ashpublications.org/blood/article/123/6/894/32581/Comparing-cancer-vs-normal-gene-expression
Finally, to validate the functional relevance of one of the transcriptional programs identified by the CvN method, we performed cell cycle analysis on CD34+ ...
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44 Clinical significance of the immune microenvironment in ...
https://pubs.rsc.org/en/content/articlelanding/2018/mo/c8mo00128f
Ovarian cancer is one of the leading causes of death from gynecologic malignancy in women. High-grade serous carcinomas, low-grade serous carcinomas, ...
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45 Cancer - UpToDate
https://www.uptodate.com/contents/table-of-contents/patient-education/cancer
... Choosing surgical treatment for early-stage breast cancer (The Basics) ... of undetermined significance (The Basics) · Multiple myeloma (The Basics) ...
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46 Prognostic significance of blood coagulation tests in lung cancer
https://erj.ersjournals.com/content/17/4/667
Prognostic significance of blood coagulation tests in lung cancer. D. Ferrigno, G. Buccheri, I. Ricca. European Respiratory Journal 2001 17: 667-673; ...
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47 The Importance of HeLa Cells - Johns Hopkins Medicine
https://www.hopkinsmedicine.org/henriettalacks/importance-of-hela-cells.html
... a remarkably durable and prolific line of cells obtained during the treatment of Henrietta's cancer by Johns Hopkins researcher Dr. George Gey in 1951.
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48 MGUS (Monoclonal Gammopathy Of Unknown Significance)
https://www.macmillan.org.uk/cancer-information-and-support/worried-about-cancer/pre-cancerous-and-genetic-conditions/mgus
Although MGUS is not a cancer, people with it have a slightly higher risk of developing: myeloma (a cancer of blood cells called plasma cells); lymphoma (a ...
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49 European Journal of Cancer: Home Page
https://www.ejcancer.com/
Richard Marais (Cancer Research UK Manchester Institute, UK) finds that circulating cell-free DNA is a surrogate marker of tumour burden in patients with ...
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50 OncoPanel - Cancer Genetics and Genomics Laboratory
http://cancergeneticslab.ca/genes/oncopanel/
All the genes targeted by this assay (see below) are screened for DNA changes (variants). The clinical significance of variants or variant combinations is then ...
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51 Cancer cell - Wikipedia
https://en.wikipedia.org/wiki/Cancer_cell
Cancer cells are cells that divide continually, forming solid tumors or flooding the blood with abnormal cells. Cell division is a normal process used by ...
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52 Cancer Cells: How They Start and Characteristics
https://www.verywellhealth.com/what-are-cancer-cells-2248795
Cancer cells differ from normal cells in the body in many ways. Normal cells become cancerous when a series of mutations leads the cells to ...
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53 Getting Genetic Test Results - Breastcancer.org
https://www.breastcancer.org/genetic-testing/getting-results
About breast cancer · Types of breast cancer · Signs and symptoms ... What to do if your genetic test finds variants of unknown significance.
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54 Overcoming Cancer: The Importance of a Strong Support ...
https://weillcornell.org/news/overcoming-cancer-the-importance-of-a-strong-support-network
The good news is that no form of cancer has to be a death sentence. Almost all forms of cancer are treatable—as long as the disease is caught in ...
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55 Cancers of public health significance - Health Knowledge
https://www.healthknowledge.org.uk/public-health-textbook/disease-causation-diagnostic/2b-epidemiology-diseases-phs/cancers
Epidemiology of Cancers of Public Health Significance Index · Bladder Cancer · Breast Cancer · Cervical Cancer · Colorectal Cancer · Liver Cancer · Lung Cancer ...
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56 National Cancer Awareness Day 2022: History, significance ...
http://zeenews.india.com/health/national-cancer-awareness-day-2022-history-significance-and-all-about-this-day-2532133
National Cancer Awareness Day 2022: In India, nearly 1.1 million new cases are reported annually. Cancer is the second-leading cause of ...
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57 Astellas Announces Zolbetuximab Meets Primary Endpoint in ...
https://newsroom.astellas.us/2022-11-16-Astellas-Announces-Zolbetuximab-Meets-Primary-Endpoint-in-Phase-3-SPOTLIGHT-Trial-as-First-Line-Treatment-in-Claudin-18-2-Positive,-HER2-Negative-Locally-Advanced-or-Metastatic-Gastric-and-Gastroesophageal-Junction-GEJ-Cancers
... primary endpoint showing statistical significance in progression-free ... Zolbetuximab acts by binding to CLDN18.2 on the cancer cell ...
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58 The 'Good' Cancer Does Not Exist - Cure Today
https://www.curetoday.com/view/the-good-cancer-does-not-exist
Some cancers, probably because of signs or symptoms that allow for earlier detection and thus earlier intervention, have better overall survival ...
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59 The PACT Act And Your VA Benefits | Veterans Affairs
https://www.va.gov/resources/the-pact-act-and-your-va-benefits/
Brain cancer; Gastrointestinal cancer of any type; Glioblastoma; Head cancer ... Monoclonal gammopathy of undetermined significance (MGUS).
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60 Integrative Oncology in Young Women With Breast Cancer
https://www.cancernetwork.com/view/journal-integrative-oncology-in-young-women-with-breast-cancer
All statistics were calculated using SAS 9.4 and significance was assessed at P <.05. Results. figure image. TABLE 1. Patient Demographics and ...
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61 Association of Breast Cancer Recurrence in Patients ...
https://ascopost.com/news/september-2022/association-of-breast-cancer-recurrence-in-patients-achieving-pcr-with-vs-without-residual-dcis-after-neoadjuvant-chemotherapy/
In the trial, women with stage II/III breast cancer at high risk of ... have different prognostic significance in subtype specific analyses.
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62 What Role Now for Margetuximab in HER2 Breast Cancer?
https://www.medscape.com/viewarticle/984008
Although this was statistically significant, “I would argue that the improvement in PFS did not reach clinical significance,” Miller said.
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63 Lynparza in combination with abiraterone recommended for ...
https://www.astrazeneca.com/media-centre/press-releases/2022/lynparza-in-combination-with-abiraterone-recommended-for-approval-in-the-eu-by-chmp-as-1st-line-treatment-for-patients-with-metastatic-castration-resistant-prostate-cancer.html
... statistical significance at the time of this data cut-off (analysis at 40% data maturity). Prostate cancer is the most common cancer in ...
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64 Five-year survival rate and prognostic factors in women with ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0277194
Breast cancer (BC) is the most prevalent malignancy and the leading cause of cancer death among women globally, accounting for 14.7% of all ...
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65 Study Looks for Ways to Reduce Incidence of Tobacco ...
https://www.targetedonc.com/view/study-looks-for-ways-to-reduce-incidence-of-tobacco-associated-pancreatic-cancer
Though pancreatic cancer is currently the 12th most commonly diagnosed cancer worldwide, and it is currently the third leading cause of cancer- ...
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66 Physical exercise lowers risk of cancer metastasis by 72%
https://www.israel21c.org/physical-exercise-lowers-risk-of-cancer-metastasis-by-72/
Study finds that high-intensity aerobic workouts prevent cancer from ... The study's significance is underlined by the fact that it was ...
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67 How cancer screening and detection has changed ... - The Week
https://www.theweek.in/theweek/cover/2022/11/17/cancer-screening-and-detection-post-covid.html
It is in cases like these that the significance of early detection and diagnosis through screening becomes even more pronounced. The only way to ...
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68 Courage, Hope, Strength: Breast Cancer Awareness Walk ...
https://news.stonybrook.edu/homespotlight/courage-hope-strength-breast-cancer-awareness-walk-brings-community-together/
The Center worked with the Stony Brook Cancer Center and the Carol ... They stressed the significance of listening to your body as the key ...
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69 What is Cancer?
https://www.cancer.net/navigating-cancer-care/cancer-basics/what-cancer
As a cancerous tumor grows, the bloodstream or lymphatic system may carry cancer cells to other parts of the body. During this process, the cancer cells grow ...
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70 Feinberg School of Medicine - Northwestern University
https://www.feinberg.northwestern.edu/
Protein promotes cancer cell proliferation and survival. ... scientific work of lasting significance; visit the links below to learn about eligibility, ...
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71 The protein behind immunotherapy resistance - EurekAlert!
https://www.eurekalert.org/news-releases/971676
Immunotherapy is a cutting-edge approach to treating cancer by ... which was to determine the functional significance of FMRP in those ...
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72 Study finds common mechanism tumours use to suppress ...
https://theprint.in/health/study-finds-common-mechanism-tumours-use-to-suppress-immune-responses/1224359/
This protein constructs a complex barrier to anti-cancer immune responses in ... Its significance in the development of cancer remained less ...
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73 New approach to lung cancer has patient diagnosed and ...
https://wgntv.com/news/medical-watch/new-approach-to-lung-cancer-has-patient-diagnosed-and-treated-all-in-one-day/
CHICAGO —A new approach to lung cancer: From diagnosis to treatment, all in one day. It's typically a nerve-wracking delay.
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74 Cancer: Symptoms, Stages, Types & What It Is - Cleveland Clinic
https://my.clevelandclinic.org/health/diseases/12194-cancer
Cancer happens when normal cells become cancerous cells that multiply and spread. Cancer is the second most common cause of death in the U.S. ...
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75 What is Cancer, Is it Common & How Do You Get It | CTCA
https://www.cancercenter.com/what-is-cancer
Cancer is the uncontrolled growth of abnormal cells in the body. Cancer develops when the body's normal control mechanism stops working.
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76 Cancer - State of Michigan
https://www.michigan.gov/mdhhs/keep-mi-healthy/chronicdiseases/cancer
Are you looking for women's health services from the Breast and Cervical Cancer Control Navigation Program (BC3NP) or the WISEWOMAN program? Click the links or ...
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77 What Causes Cancer? | Stanford Health Care
https://stanfordhealthcare.org/medical-conditions/cancer/cancer/cancer-causes.html
There is no one single cause for cancer. Scientists believe that it is the interaction of many factors together that produces cancer.
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78 Basic Facts About Breast Health: Breast Cancer Biology
https://www.ucsfhealth.org/education/basic-facts-about-breast-health-breast-cancer-biology
Cancer is a group of more than 100 different diseases. Cancer occurs when, for unknown reasons, cells become abnormal and divide without control or order.
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79 Cancer: A major national concern | Health Policy Institute
https://hpi.georgetown.edu/cancer/
Americans consistently rank cancer as one of the most important health problems facing the nation.(1) It is the second leading cause of death in the United ...
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80 Breast Cancer - Page 114 - Google Books Result
https://books.google.com/books?id=AL3kBwAAQBAJ&pg=PA114&lpg=PA114&dq=what+is+the+significance+of+cancer&source=bl&ots=XxU5HfVcSs&sig=ACfU3U0FbpAgtkuVWg_xIPa0EqhroclLdQ&hl=en&sa=X&ved=2ahUKEwiIpezGtb77AhXSHDQIHV_9ATIQ6AF6BQi4AhAD
Prognostic significance of peritumoral vascular invasion in breast cancer. Br J Cancer 1984:50:771–777. Pettelheim R, Mitchell D, Gusterson BA.
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81 The Future of Prevention and Treatment of Breast Cancer
https://books.google.com/books?id=xDw6EAAAQBAJ&pg=PA25&lpg=PA25&dq=what+is+the+significance+of+cancer&source=bl&ots=3B-LW3lLR4&sig=ACfU3U0ompDuxqlB4czA3FVc0hUUgNS9pw&hl=en&sa=X&ved=2ahUKEwiIpezGtb77AhXSHDQIHV_9ATIQ6AF6BQi7AhAD
Structural representations of tumor-host relationships in mammary carcinoma. Biologic prognostic significance. American Journal of Clinical Pathology, 26, ...
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82 Prostate Cancer: New Insights for the Healthcare ...
https://books.google.com/books?id=KWr_pCF-qF4C&pg=PA54&lpg=PA54&dq=what+is+the+significance+of+cancer&source=bl&ots=3rzZcwmgHF&sig=ACfU3U0Y2Gx3vojz5YWZ5UdgNNMj8N4FXw&hl=en&sa=X&ved=2ahUKEwiIpezGtb77AhXSHDQIHV_9ATIQ6AF6BQi-AhAD
Akita University School of Medicine: Clinical significance of polymorphism and expression of chromogranin a and endothelin-l in prostate cancer Researchers ...
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83 Cancer Treatment Reports - Volume 67 - Page 9 - Google Books Result
https://books.google.com/books?id=Ajg7dpmvq-oC&pg=PA9&lpg=PA9&dq=what+is+the+significance+of+cancer&source=bl&ots=W1JiuJPc2I&sig=ACfU3U3qiRAb0izML8qc2DJ63Qqsv3RzEg&hl=en&sa=X&ved=2ahUKEwiIpezGtb77AhXSHDQIHV_9ATIQ6AF6BQi_AhAD
... lodocholesterol adrenal scanning for the detection of adrenal metastases in lung cancer and its clinical significance . Cancer 48 : 714-716 , 1981 . 37.
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